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In two cases of diabetes insipidus (a five-year-old girl and a eight-year-old boy), oral administration of chlorpropamide in doses of 125~250 mg per day produced marked antidiuresis and concentration of urine. It was noted that the agent was effective also in the vasopressin-insensitive case (8-year-old boy). During the treatment endogenous creatinine clearance and the amount of sodium excreted, as well... |
