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Original Article
Clinical characteristics of pediatric patients infected with SARS-CoV-2 versus common human coronaviruses: a national multicenter study
In Suk Sol, Eun Lee, Hyeon-Jong Yang, Yong Ju Lee, Hye Yung Yum, Mi-Hee Lee, Mi Ae Chu, Hui Jeong Moon, Hyo-Bin Kim, Ju Hee Seo, Jung Yeon Shim, Ji Young Ahn, Yoon Young Jang, Hai Lee Chung, Eun Hee Chung, Kyunghoon Kim, Bong-Seong Kim, Cheol Hong Kim, Yang Park, Meeyong Shin, Kyung Suk Lee, Man Yong Han, Soo-Jong Hong, Eun Kyeong Kang, Chang Keun Kim
Background: Human coronaviruses (HCoV) cause mild upper respiratory infections; however, in 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged, causing an acute respiratory disease pandemic. Coronaviruses exhibit marked epidemiological and clinical differences.
Purpose: This study compared the clinical, laboratory, and radiographic findings of children infected with SARS-CoV-2 versus HCoV. Methods: SARS-CoV-2 data were obtained from the Korea...
Neurology
Neurodevelopmental outcomes and comorbidities of children with congenital muscular torticollis: evaluation using the National Health Screening Program for Infants and Children database
Og Hyang Kim, Seung Won Lee, Eun Kyo Ha, Ju Hee Kim, Yun Hye Jo, Seongyeong Rhie, Man Yong Han, Kyu Young Chae
Clin Exp Pediatr. 2022;65(6):312-319.   Published online December 9, 2021
Question: What comorbidities are increased in children with congenital muscular torticollis (CMT)? Are there differences in the neurodevelopmental outcomes of children with CMT who received physical therapy versus those who did not?
Finding: The risk of congenital musculoskeletal deformities is increased in CMT. Children who did not receive physical therapy were at greater risk of neurodevelopmental delay.
Meaning: In CMT, musculoskeletal comorbidities should be identified and active early treatment provided.
Allergy
Cohort profile: National Investigation of Birth Cohort in Korea study 2008 (NICKs-2008)
Ju Hee Kim, Jung Eun Lee, So Min Shim, Eun Kyo Ha, Dong Keon Yon, Ok Hyang Kim, Ji Hyeon Baek, Hyun Yong Koh, Kyu Young Chae, Seung Won Lee, Man Yong Han
Clin Exp Pediatr. 2021;64(9):480-488.   Published online January 5, 2021
This national cohort study included all Korean children born in 2008 and 2009 observed over a period of more than 10 years. Our findings demonstrate that it is possible to analyze disease onset prior to hospitalization based on information such as lifestyle, eating habits, and risk factors by integrating National Health Insurance System data with national health screening data.
Review Article
Allergy
Prevalence, comorbidities, diagnosis, and treatment of nonallergic rhinitis: real-world comparison with allergic rhinitis
Hye Yung Yum, Eun Kyo Ha, Yoon Ho Shin, Man Yong Han
Clin Exp Pediatr. 2021;64(8):373-383.   Published online August 10, 2020
Rhinitis is among the most common respiratory diseases in children. Nonallergic rhinitis, which involves nasal symptoms without evidence of systemic allergic inflammation or infection, is a heterogeneous entity with diverse manifestations and intensities. Nonallergic rhinitis accounts for 16%–89% of the chronic rhinitis cases, affecting 1%–50% (median 10%) of the total pediatric population. The clinical course of nonallergic rhinitis is generally...
Perspective
Other
The long journey toward improving children’s health: from ‘Korean Journal of Pediatrics’ to ‘Clinical and Experimental Pediatrics
Man Yong Han, Yeong Ho Rha, Chong-Woo Bae, Baik-Lin Eun; Clinical and Experimental Pediatrics Editorial Team
Clin Exp Pediatr. 2020;63(1):1-2.   Published online January 15, 2020
Original Article
Pulmonology
Clinical predictors of chest radiographic abnormalities in young children hospitalized with bronchiolitis: a single center study
Ga Ram Kim, Min Sun Na, Kyung Suk Baek, Seung Jin Lee, Kyung Suk Lee, Young Ho Jung, Hye Mi Jee, Tae Hee Kwon, Man Yong Han, Youn Ho Sheen
Clin Exp Pediatr. 2016;59(12):471-476.   Published online December 31, 2016
Purpose

Chest radiography is often performed on patients hospitalized with typical clinical manifestations of bronchiolitis. We aimed to determine the proportion of subjects with pathologic chest radiographic findings and the clinical predictors associated with pathologic chest radiographic findings in young children admitted with the typical presentation of bronchiolitis.

Methods

We obtained the following data at admission: sex, age, neonatal history, past history of...

Low levels of tissue inhibitor of metalloproteinase-2 at birth may be associated with subsequent development of bronchopulmonary dysplasia in preterm infants
Choae Lee, Jaewoo An, Ji Hee Kim, Eun Sun Kim, Soo Hyun Kim, Yeon Kyung Cho, Dong Hyun Cha, Man Yong Han, Kyu Hyung Lee, Youn Ho Sheen
Clin Exp Pediatr. 2015;58(11):415-420.   Published online November 22, 2015
Purpose

Bronchopulmonary dysplasia (BPD) is characterized by inflammation with proteolytic damage to the lung extracellular matrix. The results from previous studies are inconsistent regarding the role of proteinases and antiproteinases in the development of BPD. The aim of the present study was to investigate whether matrix metalloproteinase (MMP)-8, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-2, and TIMP-1 levels in the serum of...

Food allergen sensitization in young children with typical signs and symptoms of immediate-type food allergies: a comparison between monosensitized and polysensitized children
Na Yeon Kim, Ga Ram Kim, Joon Hwan Kim, Ji Hyeon Baek, Jung Won Yoon, Hye Mi Jee, Hye Sung Baek, Yong Ho Jung, Sun Hee Choi, Ki Eun Kim, Youn Ho Shin, Hye Yung Yum, Man Yong Han, Kyu-Earn Kim
Clin Exp Pediatr. 2015;58(9):330-335.   Published online September 21, 2015
Purpose

The clinical interpretation of children sensitized to allergens is challenging, particularly in children with food allergies. We aimed to examine clinical differences between children with monosensitization and those with polysensitization to common food allergens and to determine risk factors for polysensitization in young children <10 years of age with immediate-type food allergies.

Methods

The study included children <10 years of age with...

Clinical risk factors associated with the development of wheezing in children less than 2 years of age who required hospitalization for viral lower respiratory tract infections
Joon Hwan Kim, Ji-Yeon Choi, Na Yeon Kim, Jin Woo Kim, Ji Hyeon Baek, Hye Sung Baek, Jung Won Yoon, Hye Mi Jee, Sun Hee Choi, Hyeung Yoon Kim, Ki Eun Kim, Youn Ho Shin, Man Yong Han
Clin Exp Pediatr. 2015;58(7):245-250.   Published online July 22, 2015
Purpose

Wheezing following viral lower respiratory tract infections (LRTIs) in children <2 years of age is an important risk factor for the development of asthma later in life; however, not all children with viral LRTIs develop wheezing. This study investigated risk factors for the development of wheezing during viral LRTIs requiring hospitalization.

Methods

The study included 142 children <2 years of age hospitalized...

Review Article
Determinants of sensitization to allergen in infants and young children
Hyeong Yun Kim, Youn Ho Shin, Man Yong Han
Clin Exp Pediatr. 2014;57(5):205-210.   Published online May 31, 2014

Atopic sensitization is a complex phenomenon that changes dynamically with age throughout childhood; its prevalence increases with age in young children. Additionally, with increasing age, the prevalence of sensitization to inhalant allergens and the prevalence of polysensitization to allergens increase. It is also well established that the development of atopic sensitization is the result of a complex interplay of genetic...

Original Article
Prevalence and comorbidity of allergic diseases in preschool children
Hyeong Yun Kim, Eun Byul Kwon, Ji Hyeon Baek, Youn Ho Shin, Hye Yung Yum, Hye Mi Jee, Jung Won Yoon, Man Yong Han
Clin Exp Pediatr. 2013;56(8):338-342.   Published online August 27, 2013
Purpose

Allergic disease and its comorbidities significantly influence the quality of life. Although the comorbidities of allergic diseases are well described in adult populations, little is known about them in preschool children. In the present study, we aimed to assess the prevalence and comorbidity of allergic diseases in Korean preschool children.

Methods

We conducted a cross-sectional study comprising 615 Korean children (age, 3...

Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis
Ji Hyeon Baek, Hyun Kyong Seo, Hye Mi Jee, Youn Ho Shin, Man Yong Han, Eun Sang Oh, Hyun Ju Lee, Kyung Hyo Kim
Clin Exp Pediatr. 2013;56(7):286-290.   Published online July 19, 2013
Purpose

Although chronic and recurrent rhinosinusitis is prevalent in children, little is known about its causes. Here, we investigated the humoral immunity in children with chronic or recurrent rhinosinusitis.

Methods

We examined 16 children attending the outpatient clinic at the CHA Bundang Medical Center including 11 boys and 5 girls, aged 3.11 years (mean age, 5.6 years), who had rhinosinusitis for >3 months...

Impact factor of Korean Journal of Pediatrics on Korean Medical Citation Index and Science Citation Index of Web of Science
Chong Woo Bae, Sun Hee Choi, Man Yong Han, Yeong Ho Rha, Young Jin Lee
Clin Exp Pediatr. 2011;54(4):152-156.   Published online April 30, 2011
Purpose

The total number of times a paper is cited, also known as the impact factor (IF) of a medical journal, is widely implied in evaluating the quality of a research paper. We evaluated the citation index data as an IF of Korean J Pediatr in Korean Medical Citation Index (KoMCI) and JCI of Web of Science.

Methods

We calculated the IF of...

Reference values for respiratory system impedance using impulse oscillometry in healthy preschool children
Jye Hae Park, Jung Won Yoon, Youn Ho Shin, Hye Mi Jee, Young Sun Wee, Sun Jung Chang, Jung Hwa Sim, Hye Yung Yum, Man Yong Han
Clin Exp Pediatr. 2011;54(2):64-68.   Published online February 28, 2011
Purpose

The normal values for lung resistance and lung capacity of children, as determined by impulse oscillometry (IOS), are different for children of different ethnicities. However, reference values there is no available reference value for Korean preschool children have yet to be determined. The aim of the present study was to determine the normal ranges of IOS parameters in Korean preschool...

Increased B cell-activating factor (BAFF) level in the sputum of children with asthma
Hye Mi Jee, Bong Seok Choi, Kyung Won Kim, Myung Hyun Sohn, Man Yong Han, Kyu-Earn Kim
Clin Exp Pediatr. 2010;53(8):795-800.   Published online August 31, 2010
Purpose

B cell-activating factor (BAFF) is a tumor-necrosis factor (TNF) superfamily member best known for its role in the survival and maturation of B cells. BAFF activity is observed in naïve cells as well as in effector/memory T cells. We aimed to explore whether BAFF in sputum is expressed at elevated levels in asthmatic airways and associated with eosinophilic inflammation, pulmonary...

Analysis of reports on orphan lung diseases in Korean children
Sun Jung Jang, Hyun Kyung Seo, Sung Jae Yi, Kyong Min Kim, Hye Mi Jee, Man Yong Han
Clin Exp Pediatr. 2010;53(6):711-717.   Published online June 23, 2010
Purpose

Orphan lung diseases are defined as lung diseases with a prevalence of 1 or less in 2,000 individuals. Despite an increase in the numbers of patients with such diseases, few studies on Korean children have appeared. To obtain epidemiologic and demographic data on these diseases, we systematically reviewed reports on pediatric orphan lung diseases in Korea over the last 50...

The quality control and acceptability of spirometry in preschool children
Hyun Kyong Seo, Sun Jung Chang, Da Woon Jung, Young Sun Wee, Hye Mi Jee, Ji Young Seo, Man Yong Han
Clin Exp Pediatr. 2009;52(11):1267-1272.   Published online November 15, 2009
Purpose : We examined the ability of preschool aged children to meet the American Thoracic Society (ATS) and European Resiratory Society (ERS) goals for spirometry quality and tried to find out the major factor for improving the rate of success of spiromety test in this age group. Methods : Spirometry was performed in 2-6 aged 155 children with chronic cough or...
Toll-like receptor 9 expression and interferon-α secretion upon CpG-ODN stimulation in allergic subjects
Man Yong Han, Hye Mi Jee, Hyeong Yoon Kim, Cho Ae Lee, Hyo-Jin Cho, Seong-Gyu Hwang, Kyu-Earn Kim
Clin Exp Pediatr. 2009;52(9):1015-1020.   Published online September 15, 2009

Purpose:The aim of this study is to explore the effect of the Toll-like receptor 9 (TLR9) expressed in plasmacytoid dendritic cells (pDCs) that respond to antigen to Th2 immune deviation in allergic patients. Methods:Subjects consisted of 19 allergic patients and 17 healthy volunteers. Skin prick tests and nasal provocation tests were performed for the two groups. Peripheral blood mononuclear cells (PBMCs)...
Case Report
Methemoglobinemia development after ingestion of a chinese herbal medicine: A case report
Se Eun Hyun, Pil Joo Hwang, Kyung Pil Nam, Eun Gyong Yoo, Man Yong Han
Clin Exp Pediatr. 2008;52(3):385-388.   Published online March 15, 2009
An 8-year-old girl visited the emergency room with perioral cyanosis and dyspnea, which had developed 20 hrs prior to the hospital visit. She had taken a Chinese herbal medication for 3 days prior to the onset of the symptoms. A co-oximeter examination revealed a methemoglobin level of 23.7%. An intravenous infusion of methylene blue was administered. Chemical analysis of the...
Pulmonary arteriovenous malformation manifesting with perioral cyanosis and dyspnea on exertion: A case report
Yu Kyung Kim, Jin Woo Kim, Gun Lee, Man Yong Han
Clin Exp Pediatr. 2009;52(1):124-128.   Published online January 15, 2009
Pulmonary arteriovenous malformations (PAVMs) are direct communications between pulmonary arteries and pulmonary veins, resulting in right-to-left shunts that may cause cyanosis, dyspnea, and digital clubbing. Neurological complications such as intracerebral hemorrhage or brain abscess may result from cerebral thrombosis or emboli. In most cases, they remain unrecognized until the late teenage years. Here, we report a case of a 6-year-old...
Original Article
Safety and efficacy of the ultra-rush immunotherapy with extracts of Dermatophagoides pteronyssinus in children
Sei Eun Hyun, Hyoung Yun Kim, Ji Hee Kwak, Youn Ho Shin, Ji Yeong Seo, Man Yong Han
Clin Exp Pediatr. 2008;51(8):868-873.   Published online August 15, 2008
Purpose : Immunotherapy is accepted as the only treatment of allergic disease that can modify the natural course of the disease and ameliorate symptoms. This study aimed to evaluate the safety and efficacy of ultra-rush therapy using Dermatophagoides extracts in children. Methods : Of children older than four years who had visited Bundang CHA Pediatric Allergy Clinic, those showing positive...
A comparison between impulse oscillometry system and spirometry for spirometry for detecting airway obstruction in children
Hae Young Hur, Ji Hee Kwak, Hyoung Yun Kim, Da Wun Jung, Yoon Ho Shin, Man Yong Han
Clin Exp Pediatr. 2008;51(8):842-847.   Published online August 15, 2008
Purpose : Measurement of forced expiratory volume in 1 second (FEV1) is usually difficult to obtain in children under six years of age because it requires active cooperation. This study evaluates the sensitivity of impulse oscillometry system (IOS) parameters for detecting airway obstruction in comparison with FEV1. Methods : We studied 174 children who performed the lung function and methacholine challenge...
Reference values for respiratory system impedance using impulse oscillometry in school-aged children in Korea
Young Sun Wee, Hyoung Yun Kim, Da Wun Jung, Hye Won Park, Yoon Ho Shin, Man Yong Han
Clin Exp Pediatr. 2007;50(9):862-867.   Published online September 15, 2007
Purpose : The impulse oscillometry (IOS) is applicable to young children because it requires minimal cooperation and a non-invasive method to measure the mechanics of respiratory system. This study aimed to develop the reference values in school-aged children in Korea, using IOS which is a modification of forced oscillation technique (FOT). Methods : Measurements were performed in 92 previously untrained healthy...
Clinical Lecture
Cow's Milk Allergy in Infants and Young Children
Man Yong Han
Clin Exp Pediatr. 2003;46(9):839-845.   Published online September 15, 2003
Original Article
Accuracy of References in Journal of the Korean Pediatric Society and Journals of the Korean Pediatric Subspecialty Societies and Citation Pattern Analysis
Gil Ho Cho, Mi Kyung Lee, Man Yong Han, Young Rae Kim, Seo Jung Kim, Kyu Hyung Lee
Clin Exp Pediatr. 2002;45(11):1325-1331.   Published online November 15, 2002
Purpose : We tried to check the accuracy of references in the Journal of the Korean Pediatric Society and Journals of the Korean Pediatric Subspecialty Societies. We also wanted to know the citation patterns of authors by analyzing the frequency of cited materials. Methods : Three journals were randomly selected from the 2000 issues of Journal of the Korean Pediatric Society...
Estimation of the Possible Age for Using Various Types of Inhaler by In-Check Inspiratory Flow Meter(TM)
Kyung Hyun Jung, Sun Ye Kim, Jun Ho Lee, Kye Sung Kim, Yook Jang, Man Yong Han
Clin Exp Pediatr. 2002;45(2):192-198.   Published online February 15, 2002
Purpose : It is important to select and use kinds of Inhaler appropriate to the age of the patient and severity of symptoms. Several kinds of Inhaler have been developed and recommended according to each inhaler's resistance and usage method. We evaluated the usable age of 4 inhalers (turbulent flow inhalers, multi unit dose inhalers, breath actuated MDI, and autohalers)...
Case Report
Five Cases of Prader-Willi or Angelman Syndrome Diagnosed by FISH in Neonate and Infancy
Hee Jung Chung, Young Rae Kim, Man Yong Han, Sook Hwan Lee
Clin Exp Pediatr. 2000;43(3):417-422.   Published online March 15, 2000
The Prader-Willi syndrome(PWS) and Angelman syndrome(AS) are clinically distinct syndromes with a shared cytogenetic deletion of chromosome 15q11q13 in most patients. Currently the diagnosis of PWS/AS is clinically suspected and can be confirmed by genetic laboratory tests. However, their diagnosis remains difficult in neonates and early infants because many features of the syndromes change with age and the typical features...
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