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Original Article
Oligohydramnios affects pulmonary functional/structural abnormalities in school-aged children with bronchopulmonary dysplasia
Jeong Eun Shin, Soon Min Lee, Mi-Jung Lee, Jungho Han, Joohee Lim, Haerin Jang, Ho Seon Eun, Min Soo Park, Soo Yeon Kim, Myung Hyun Sohn, Ji Ye Jung, Kyung Won Kim
Question: Is bronchopulmonary dysplasia (BPD) associated with functional/structural abnormalities later in life?
Finding: School-aged children with severe BPD had abnormalities on pulmonary function tests and lung computed tomography despite no subjective respiratory symptoms; however, only prenatal oligohydramnios and prolonged ventilator use were associated with abnormal lung function.
Meaning: Long-term monitoring of preterm infants’ lung health is essential, especially for those with prenatal oligohydramnios or prolonged ventilator use.
DOI: https://doi.org/10.3345/cep.2023.01053    [Epub ahead of print]
Increased B cell-activating factor (BAFF) level in the sputum of children with asthma
Hye Mi Jee, Bong Seok Choi, Kyung Won Kim, Myung Hyun Sohn, Man Yong Han, Kyu-Earn Kim
Clin Exp Pediatr. 2010;53(8):795-800.   Published online August 31, 2010
Purpose

B cell-activating factor (BAFF) is a tumor-necrosis factor (TNF) superfamily member best known for its role in the survival and maturation of B cells. BAFF activity is observed in naïve cells as well as in effector/memory T cells. We aimed to explore whether BAFF in sputum is expressed at elevated levels in asthmatic airways and associated with eosinophilic inflammation, pulmonary...

Case Report
Thymolipoma in a 13-year-old Korean girl
Su-Jin Park, Ji Young Baek, Junjeong Choi, Kyung Won Kim, Myung Joon Kim, Myung Hyun Sohn, Kyu-Earn Kim
Clin Exp Pediatr. 2010;53(1):103-105.   Published online January 15, 2010
Thymolipoma is a rare benign tumor of anterior mediastinum. Most patients are asymptomatic with incidental finding of the tumor during a diagnostic workup of other medical problems. We present a case of 13-year-old girl with anterior mediastinal thymolipoma, surgically removed after an incidental diagnosis.
Original Article
Utility of a forced expiratory flow of 25 to 75 percent as a predictor in children with asthma
Jung Wan Kang, Kyung Won Kim, Eun Soo Kim, Jun Young Park, Myung Hyun Sohn, Kyu-Earn Kim
Clin Exp Pediatr. 2008;51(3):323-328.   Published online March 15, 2008
Purpose : Asthma is defined as chronic inflammation of the lower small airways, and bronchial hyperreactivity (BHR) is a pathophysiologic feature of asthma. It has been proposed that although there is no direct variable capable of assessing the small airways, a forced expiratory flow of between 25 and 75 percent (FEF25-75) might be considered a more sensitive early marker of...
The causative organisms of pediatric empyema in Korea
Hye-yung Yum, Woo Kyung Kim, Jin Tak Kim, Hyun Hee Kim, Yeong Ho Rha, Yong Min Park, Myung Hyun Sohn, Kang Mo Ahn, Soo Young Lee, Su Jong Hong, Hae Ran Lee
Clin Exp Pediatr. 2007;50(1):33-39.   Published online January 15, 2007
Department of Pediatrics , College of Medicine, Hallym University Purpose : In spite of medical advances, empyema is a serious complication of pneumonia in children. Vaccination practices and antibiotic prescribing practices promote the change of clinical manifestations of empyema and causative organisms. So we made a nationwide clinical observation of 122 cases of empyema in children from 32 hospitals during...
Mycoplasma pneumoniae-induced production of proasthmatic mediators in airway epithelium
Kyung Won Kim, Byung Chul Lee, Kyung Eun Lee, Eun Soo Kim, Tae Won Song, Mi Yeoun Park, Myung Hyun Sohn, Kyu-Earn Kim
Clin Exp Pediatr. 2006;49(9):977-982.   Published online September 15, 2006
Purpose : There has been an increasing amount of literature concerning the association between Mycoplasma pneumoniae and asthma pathogenesis. Interleukin(IL)-6 stimulates the differentiation of monocytes, and can promote Th2 differentiation and simultaneously inhibit Th1 polarization. IL-8 is a potent chemoattractant and, it has been suggested, has a role in asthma pathogenesis. Nitric oxide (NO) synthesized by airway epithelium may be...
Polymorphisms of the CTLA-4 promoter(-318) and exon 1(＋49) genes with atopic dermatitis in Korean children
Tae Won Song, Hea Sun Yang, Kyung Eun Lee, Kyung Won Kim, Eun Soo Kim, Myung Hyun Sohn, Kyu-Earn Kim, M.D
Clin Exp Pediatr. 2006;49(5):545-551.   Published online May 15, 2006
Purpose : The gene-encoding cytotoxic T lymphocyte-associated antigen-4(CTLA-4) is one of the candidate genes for conferring susceptibility to atopic dermatitis(AD). The aim of the study was to investigate the association between Korean children with AD and the polymorphisms of CTLA-4 gene promoter(-318) and exon 1(＋49). Methods : The CTLA-4 promoter(-318 T/C) and exon 1(＋49 A/G) polymorphisms were genotyped via restriction fragment...
Effects of Hyperosmolar Stimuli on Activation of Human Eosinophilic Leukaemia EoL-1 Cells
Byoung Chul Kwon, Eun Soo Kim, Kyung Won Kim, Tae Won Song, Myung Hyun Sohn, Myeong Heon Shin, Kyu-Earn Kim
Clin Exp Pediatr. 2005;48(8):881-885.   Published online August 15, 2005
Purpose : Airway dehydration and subsequent hyperosmolarity of periciliary fluid are considered critical events in exercise-induced bronchoconstriction. The aim of this study was to establish if a hyperosmolar challenge could induce activation of eosinophils. Methods : Human eosinophilic leukaemic cell lines, EoL-1 cells were incubated with hyperosmolar solutions for 15 minutes. Activation of EoL-1 cells was monitored by degranulation and superoxide...
Hemodynamic Status of Subpulmonic Ventricular Septal Defect in Relation to Morphologic Changes of Aortic Valve
Myung Hyun Sohn, Jae Young Choi, Jong Kyun Lee, Jun Hee Sul, Sung Kyu Lee, Bum Koo Cho
Clin Exp Pediatr. 1996;39(8):1103-1110.   Published online August 15, 1996
Purpose : Subpulmonic ventricular septal defect is clinically important because the risks of aortic regurgitation and endocarditis are substantially increased. This study was conducted to evaluate the effect of hemodynamic changes induced by structural anomalies of aortic valve on the surgical outcome. Methods : This clinical study was done by reviewing the medical records of 124 patients who were diagnosed and surgically managed at the...
Prognosis of Congenital Extrahepatic Biliary Atresia After Hepatic Portoenterostomy
Myung Hyun Sohn, Ki Sup Chung, Euh Ho Whang
Clin Exp Pediatr. 1996;39(5):658-664.   Published online May 15, 1996
Purpose : The surgical results for congenital extrahepatic biliary atresia have been improved since Kasai first described hepatic portoenterostomy(Kasai operation) in 1959. This study was conducted to evaluate the postoperative prognosis of congenital extrahepatic biliary atresia after hepatic portoenterostomy. Methods : This clinical study was done by reviewing the medical records of 30 patients who have undergone hepatic portoenterostomy at the Severance Hospital, Yonsei...
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