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Clinical Lecture
Oh Kyung Lee
Clin Exp Pediatr. 2005;48(7):685-690.   Published online July 15, 2005
Recently, twinning rate increases in Korea since the early 1990s by delayed marriage and prevailing of assisted reproductive technology. But twin and higher-order multiples are at increased risk for perinatal and neonatal mortality over 5 fold despite of dramatic improvement of perinatal and neonatal care. Because twins are born more prematurely and have lower birth weights than singleton. In addition,...
Original Article
Comparison of Rehospitalization during the First Year of Life in Normal and Low Birth Weight Infants Discharged from NICU
Sae Ah Min, Myung Won Jeon, Sun Hee Yu, Oh Kyung Lee
Clin Exp Pediatr. 2002;45(12):1503-1511.   Published online December 15, 2002
Purpose : Although the short- and long-term outcomes of low birth weight(LBW) neonatal intensive care unit(NICU) survivors have been extensively studied, much less information is available for normal birth weight(NBW) infants(greater than 2,500 gm) who require NICU care. Methods : We retrospectively examined the neonatal hospitalizations and one year health status of 302 NBW and 131 LBW admissions to our...
Protein and Genetic Analysis of Bruton's Tyrosine Kinase(Btk) in Three Korean X-linked Agammaglobulinemia(XLA) Families
Eun-Kyeong Jo, Chang-Hwa Song, Jeong-Kyu Park, Oh Kyung Lee, Dong-Soo Kim
Clin Exp Pediatr. 2002;45(1):44-54.   Published online January 15, 2002
Purpose : Mutations in the Bruton' s tyrosine kinase(Btk) gene are responsible for X-linked agammaglobulinemia( XLA), an immunodeficiency caused by a block in B cell differentiation. In this report we characterize the protein expression and genetic mutations of Btk in four Korean patients with three unrelated XLA families. Methods : The resulting Btk proteins were characterized by a flow cytometry and the mutations were analyzed...
Case Report
Duplication Cyst of the Pylorus in a Newborn
Seon Ja Cho, Kang Ho Lee, Myoung Jin Ju, Oh Kyung Lee
Clin Exp Pediatr. 2001;44(9):1052-1056.   Published online September 15, 2001
Enteric duplications are uncommon congenital anomalies. Duplications of the stomach account for only 3.8% of gastrointestinal duplication. More particularly, duplications involving the pylorus are extremely rare. These are characterized by firm attachment to at least one point of the alimentary tract with a well developed coat of smooth muscle and mucous membrane. The most frequent presentation is an abdominal mass with vomiting, mainly discovered...
A Case of Primary Multiple Intracerebral Aspergillosis Abscess in Neonate : Treatment with Amphotericin B, Flucytosine and Itraconazole
Byoung Lae Oh, Oh Kyung Lee, Yong Seog Kim, Young Sook Kim
Clin Exp Pediatr. 2000;43(8):1116-1121.   Published online August 15, 2000
Fungal infection of the central nervous system tends to occur mostly in immunosuppressed patients. In the pediatric population, it is usually seen in severely immunocompromised patients, particulary in children with chronic granulomatous disease and hematopoietic malignancies. Although aspergillosis is considered one of the most frequent agents of mycotic infection of the brain, it is especially rare in the neonatal period,...
Original Article
Rehospitalization of Low-birth-weight Infants Who Were Discharged from NICU
Kyung Dan Choi, Young Suk Chae, Oh Kyung Lee
Clin Exp Pediatr. 1999;42(4):484-490.   Published online April 15, 1999
Purpose : We tried to compare normal term infants with low-birth-weight infants discharged from NICU by evaluating morbidity. So we studied rates of rehospitalization, reasons for rehospitalization and neonatal risk factors that affect rehospitalization of normal term infants and low-birth-weight infants discharged from NICU. Methods : This study was performed on 217 low-birth-weight infants discharged from NICU and 126 normal term...
The Statistical Study of Patient with Acute Poisoning
Heung Pyo Kong, Kyoung Bae Park, Oh Kyung Lee, Kang Suh Park
Clin Exp Pediatr. 1997;40(11):1596-1602.   Published online November 15, 1997
Purpose : The incidence of infectious disease, which has been the cause of death in pediatric period, was decreased. But, the opportunistic exposure to toxic substance shows a tendency to increase. We performed this study in order to find out preventive measures and the latest inclination of acute poisoning in childhood. Methods : From January 1985 to July 1996, 88 children with acute drug...
Impact of Perinatal Risk Factors on Mental or Psychomotor Developmental Outcome of Very Low Birth W eight Infants
Eun Kyung Jin, Jong Uk Kim, Do Whan Kil, Oh Kyung Lee
Clin Exp Pediatr. 1997;40(9):1202-1209.   Published online September 15, 1997
Purpose : To determine which perinatal risk factors influence neurodevelopmental outcome, we try to investigate which perinatal risk factors are correlated with Baley mental or psychomotor developmental index using BSID-Ⅱ test(Baley Scales of Infant Development, Ⅱ) in long term follow up of very low birth weight who received neonatal intensive care. Methods : This study was performed on 56 very low birth weight infants with...
Growth and Neurodevelopmental Outcome on Very Low Birth Weight Infants During 2 Years
Eun Suk Kim, Jong Uk Kim, Oh Kyung Lee, Wan Soeb Kim
Clin Exp Pediatr. 1996;39(5):641-651.   Published online May 15, 1996
Purpose : By rapid development of neonatal intensive care from 1960, we are able to expect the long survival of the very low birth weight infants. But, there were high risk of poor growth, neurodevelopmental delay, deafness, and blindness in very low birth weight infants. So, it is important to follow-up after discharge. We try to compare normal term infants with...
Clinical Study on Insulin Dependent Diabetes mellitus
Seog Beom Cho, Kwang Rae Lee, Chang Beom Shin, Oh Kyung Lee, Chong Duk Kim, Oh Kyung Lee
Clin Exp Pediatr. 1995;38(6):827-834.   Published online June 15, 1995
Purpose : Insulin dependet diabetes mellitus(IDDM) is a rare disease in children, but it will progress rapidly and falls into a diabetic ketoacidosis or coma. Unfortunately, the characteristics and prevalence rate of children with IDDM are not well known in Korea. With a view to recognizing its importance, we studied clinical course of IDDM patients in Chonbuk province, Korea. Methods : From...
Neurosonographic Abnormality; Periventricular echodensities and Intraventricular Hemorrhage: Usefulness in Predicting Neurodevelopmental Outcome in Very-Low-Birth-Weight, Preterm Infants
Dae Young Jang, Keun Wook Lee, Young Taek Jang, Oh Kyung Lee, Jin Ok Choi, Yeon Hi Kim
Clin Exp Pediatr. 1994;37(10):1376-1385.   Published online October 15, 1994
Serial neurosonographic examinations are routinely performed at frequent intervals during nursery couse of all preterm infants of very low-birth-weight who are admitted to the intensive care nursery of Presbyterian Medical Center from November 1,1900 to July 30, 1992. After discharge, the following survivors who had received periodic, serial scanning by means of cranial ultrasonography were longitudinally observed in an interdisciplinary neurodevelopmental...
Clinical Study on Very Low Birth Weight Infants
Sha Young Choi, Dae Young Jang, Oh Kyung Lee, Wan Seob Kim
Clin Exp Pediatr. 1994;37(5):628-635.   Published online May 15, 1994
Medical records of very low birth weight infants weighing less than 1500 grams at birth were reviewed and analyzed. One hundred and forty three infants who were admitted to neonatal intensive care unit of Presbyterian Medical Center, including those who were born and transferred from other hospitals, from January 1987 to December 1991 were examined and the following results were obtained; 1)...
Diagnostic value and Relationship of the between Stable Microbubble rating Test and Shake Test for the Prediction of Neonatal Respiratory distress Syndrome
Seong Jin Ha, Dong Kyun Ryu, Oh Kyung Lee, Wan Seob Kim
Clin Exp Pediatr. 1994;37(5):620-627.   Published online May 15, 1994
Respiratory distress syndrome (RDS) in the newborn infants remains a major cause of mortality and morbidity in the newborn period despite much improvements in neonatal intensive care and artificial ventilatory techniques. Gastric fluid was obtained from 151 patients within 6 hours after delivery. The sensitivity, specificity, and predictive value of the simple shake test (133 cases) and stable microbubble rating...
Case Report
A Case of VATER Syndrome
Seong Jin Ha, Ki Hyun Chung, Oh Kyung Lee, Wan Seob Kim, Jae Seung Yang
Clin Exp Pediatr. 1993;36(4):583-588.   Published online April 15, 1993
The VATER syndrome is a group of congenital anomalies with a nonrandom tendency for concurrence. Defects include vertebral, anorectal malformation, tracheoesophageal fisutla with esophageal atresia, radial-limb, vascular, and renal abnormalities. The critical period of organogenesis is at or before the sixth or seventh week of gestation. We experienced one case of VATER syndrome in a 1 day old male neonate having...
Original Article
Neurosonographic Diagnosis of Periventricular-Intaventricular Hemorrhage in Low Birth Weiht Infants
Hee Seok Koh, Dong Kyun Ryu, Young Tack Jang, Oh Kyung Lee, Jin Ok Choi
Clin Exp Pediatr. 1993;36(1):57-66.   Published online January 15, 1993
Periventricular-intraventricular hemorrhage (PV-IVH) is one of the most important neurologic lesion of the low birth weight infants. Serial neurosonographic examinations were performed in 113 low birth weight infants who were admitted to the neonatal internsive care unit of Presbyterian Medical Center from November 1, 1990 to July 31, 1991. The results were summarized as follows: 1) The incidence of PV-IVH in he study...
Case Report
A Case of Poststeroid Panniculitis
Hee Seok Koh, Sha Young Choi, Sung Jin Ha, Oh Kyung Lee
Clin Exp Pediatr. 1992;35(3):411-416.   Published online March 15, 1992
Poststeroid panniculitis occuring after steroid treatment is an extremely rare entity. Multiple subcutaneous, firm, pruritic, tender nodules occur chiefly over the cheeks, arms, and trunk in young children following sudden discontinuation of large dose of steroids. We experiened a case of poststeroid panniculitis in a 2day-old female infant with complaints of multiple subcutaneous nodules on cheeks and neck for 10 days....
Original Article
Factors Associated with Pneumothorax in Hyaline Membrane Disease In fants Receiving Mechanical Ventilation.
Oh Kyung Lee, Kyung Hee Kim, Kyu Sun Choi, Wan Seoub Kim
Clin Exp Pediatr. 1989;32(12):1642-1649.   Published online December 31, 1989
We observed 42 cases of neonates, who were diagnosed as having Hyaline membrane disease and had been received mechanical ventilation in neonatal intensive care unit of Presbyterian medical center from July 1984 to July 1988. In order to observe the factors associated with pneumothorax, we devide these cases in two groups. First group was consists of infants with pneumothorax, second group was consists of...
A Study on Prognostic Factors of Meconium Aspiraion Syndrome.
Oh Kyung Lee, Hong Chul Lee, Wan Seoub Kim, Myung Ho Lee
Clin Exp Pediatr. 1988;31(9):1114-1119.   Published online September 30, 1988
We observed 42 cases of neonates, who were diagnosed as having Meconium aspiration syndrome in neonatal intensive care unit of Presbyterian Medical Center from July 1984 to May 1987. The followings were obtained: 1) The incidence of Meconium aspiration syndrome was 0.6% of all deliveries and 7.4% of meconium stained babies. 2) The geatational age was over 37 weeks in all cases and the body weight was...
Clinical Bacteriologic Study of Serratia Marcescens Septicemia.
Hyo Sook Hong, Wan Seob Kim, Oh Kyung Lee, Myung Ho Lee
Clin Exp Pediatr. 1987;30(12):1409-1418.   Published online December 31, 1987
We experienced an outbreak of Serratia marcescens septicemia during a 2-month-10-day period (Apirl the 10th, 1985-June the 6th, 1985) in the Chonju Presbyterian medical center, pediatric ward. The clinical and bacteriological features of 22 patients with septicemia were described. There were 25 bacterial isolates from 22 patients. Twenty cases of 22 patients recovered, while 2 patients died, both premature infants. This indicated the seriousness...
Case Report
A Case of Beckwith-Wiedemann Syndrome.
Hyo Sook Hong, Hong Chul Lee, Oh Kyung Lee, Myung Ho Lee
Clin Exp Pediatr. 1987;30(10):1166-1169.   Published online October 31, 1987
Beckwith-Wiedemann syndrome constitutes a clinicopathologic entity characterized macroglossia, omphalocele or umblical hernia, visceromegaly, postnatal gigantism, microcephaly, Nevus flammeus, ear lobe grooves, hemihypertrophy and other abnormalities. The anomalies of the syndrome are facultative and not obligatory. We experience one case of Beck with-Wiedemann syndrome. This 1-day-aged female neonate showed macroglossia, gigantism, omphalocele and hypoglycemia. Review of literature was done briefly.
A case of Hutchinson Gilford Progeria Syndrome.
Myung Ho Cho, Yong Woo Choi, Wan Seob Kim, Oh Kyung Lee, Myung Ho Lee
Clin Exp Pediatr. 1986;29(5):570-574.   Published online May 31, 1986
An extremely rare syndrome originally described by Hutchinson in 1886 and Gilford in 1904 is associated with a characteristic aged appearance very early in life. Although numerous clinical. metabolic and pathologic studies had been carried out and several theories advanced , the cause and pathogenesis of progeria remain obscure. The patient of this syndrome develope widespread atherosclerosis and often...
Original Article
A Clinical Study of Type A Hepatitis Confirmed by IgM Anti-HAV.
Oh Kyung Lee, Sung Seek Lee, Keun Chul Choi, Myung Ho Lee, Sook Ja Park
Clin Exp Pediatr. 1984;27(8):778-785.   Published online August 31, 1984
79 children with Type A Hepatitis who were admitted to the pediatric department of the Presbyterian Medical Center from April 1, 1983 to October 31, 1983 were clinically analized and we report the following result. 1) Type A Hepatitis occupied 8% of total in patients and 88% of total Hepatitis patients. 2)The peak age incidence was between 7 and 9 years...
Case Report
A Case of Histiocytic Medullary Reticulosis in 17 Month-old Child.
Oh Kyung Lee, Wan Seob Kim, Myung Ho Lee, Sung Seek Lee, Sook Ja Park
Clin Exp Pediatr. 1983;26(12):1220-1225.   Published online December 31, 1983
Histiocytic medullary reticulosis(HMR) is a rare, uniformly fatal, acute disease of the reticuloen dothelial system. Major features are fever, malaise, weakness, weight loss, lymphadenopathy, hepatosplenomegaly, jaundice and purpura. Common laboratory finding is severe pancytopenia. Cardinal pathologic feature is proliferation of atypical, neoplastic, erythrophagocytic histiocytes. Recently we experienced a case of HMR in 17 month-old male child. The clinical findings and...
A Case of Cushing's Syndrome.
Seong Ja Jeon, Oh Kyung Lee, Keun Chull Choi, Myung Ho Lee, Jong Deok Kim
Clin Exp Pediatr. 1983;26(9):928-933.   Published online September 30, 1983
We experienced a Cushing’s syndrome which was caused by adrenocortical carcinoma in 8-year-old boy. He has suffered from obesity, moonface and growth retardation for 2 years. The diagnosis was confirmed by clinical symptoms, biochemical studies, X-rays and pathologic examinations. A total adrenalectomy was impossible because of far extended mass to adjacent organ, so only tissue biopay was done. After surgery, he received radiation...
A Case of Salmonella Meningitis.
Oh Kyung Lee, Seok Ku Kim, Chul Lee, Myung Ho Lee
Clin Exp Pediatr. 1982;25(12):1270-1274.   Published online December 31, 1982
Salmonella meningitis is characterized by rapid clinical course and poor prognosis in young children. Authors experienced a case of Salmonella meningitis in 16-month-old boy child, who was admitted to the pediatric department with high fever and diarrhea for 5 days. The diagnosis was confirmed by positive culture of Salmonella typhi on CSF and Blood. In this article, we emphasize the atypical symptoms and sign of...
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