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Original Article
Enterovirus 71-associated hand, foot and mouth diseases with neurologic symptoms, a university hospital experience in Korea, 2009
Hye Kyung Cho, Na Yong Lee, Hyunju Lee, Hae Soon Kim, Jeong Wan Seo, Young Mi Hong, Seung Joo Lee, Sun Wha Lee, Doo Sung Cheon, Ji Young Hong, Byung Hak Kang, Jong-Hyun Kim, Kyung-Hyo Kim
Clin Exp Pediatr. 2010;53(5):639-643.   Published online May 31, 2010

Hand-foot-mouth disease (HFMD) is a common viral illness in children, which is usually mild and self-limiting. However, in recent epidemics of HFMD in Asia, enterovirus 71 (EV71) has been recognized as a causative agent with severe neurological symptoms with or without cardiopulmonary involvement. HFMD was epidemic in Korea in the spring of 2009. Severe cases with complications including death have...

Review Article
Guidelines for childhood urinary tract infection
Seung Joo Lee
Clin Exp Pediatr. 2009;52(9):976-983.   Published online September 15, 2009
Urinary tract infection (UTI), the most common bacterial disease in childhood, is frequently associated with urinary tract anomalies (15-50%) and can induce renal scarring, which is a cause of hypertension and chronic kidney disease. Despite the high risk of renal scarring in infancy, the diagnosis may be delayed due to its nonspecific presenting symptoms; moreover, over-diagnosis is frequent due to...
Original Article
Bacterial meningitis in children experienced at a university hospital, 1993-2006
Sung Yoon Cho, Tae Yeon Kim, Hyunju Lee, Kyung Hyo Kim, Eun Sun Yoo, Hae Soon Kim, Eun Ae Park, Kyung Ha Ryu, Jeong Wan Seo, Sejung Sohn, Seung Joo Lee
Clin Exp Pediatr. 2008;51(10):1077-1084.   Published online October 15, 2008
Purpose : Despite the seriousness of bacterial meningitis in children, there is little information on the incidence, causative organisms, mortality rate and age distribution. We studied the frequency by age group and causal pathogens, and clinical characteristics in children with bacterial meningitis in the private sector in Korea. Methods : The medical records containing the data on bacterial meningitis patients...
Benign Transient Hyperphosphatasemia of Infancy and Childhood
Jung Hyun Kwon, Ji Hye Park, Hae Soon Kim, Seung Joo Lee, Mi Ae Lee
Clin Exp Pediatr. 2005;48(3):306-309.   Published online March 15, 2005
Purpose : The aim of study is to investigate the clinical manifestations and the etiology of markedly-elevated serum alkaline phosphatase(ALP) levels in children without accompanying liver or bone disease. Methods : The serum ALP and other biochemical laboratory data of 4,989 patients attending the pediatric department of Ewha Womans University Mokdong Hospital between January 2002 to December 2002 were studied. The...
The Change in Intestinal Lactobacillus Count among Healthy Neonates
Hyun Joo Lee, Hyun Ji Lee, Su Jin Cho, Jung Wan Seo, Seung Joo Lee, Eun Ae Park
Clin Exp Pediatr. 2004;47(8):833-838.   Published online August 15, 2004
Purpose : Enhancing overall health by preventive and therapeutic use of probiotics has shown great promise on inflammatory, infectious, neoplastic disorders, allergies, et al. To attain preliminary data for the use of probiotics, we have studied the change in intestinal flora, Lactobacillus count among healthy, full term neonates. Methods : Fresh stool samples were collected on the 2nd or 5th day...
Prognostic Value of Repeated Cerebrospinal Latex Agglutination Testing in Bacterial Meningitis
Soo Jeong Lee, So Hyun Ahn, Su Jin Cho, Hae Soon Kim, Seung Joo Lee
Clin Exp Pediatr. 2003;46(4):345-350.   Published online April 15, 2003
Purpose : Bacterial meningitis is a serious infection of childhood associated with a significant morbidity and mortality. Repeated cerebrospinal fluid(CSF) examination is a useful prognostic indicator and a delayed sterilization is associated with a higher incidence of neurologic abnormalities. In this study we tried to determine the prognostic value of repeated CSF latex agglutination testing. Methods : We retrospectively evaluated 19...
Case Report
A Case of Kawasaki Disease Associated with Acute Renal Failure and Necrotizing Myositis
So Hyun Ahn, So Yun Shim, Sejung Sohn, Seung Joo Lee, Un Seop Han
Clin Exp Pediatr. 2003;46(2):207-209.   Published online February 15, 2003
Kawasaki disease is an acute febrile vasculitis affecting primarily infants and young children. In addition to the cardiovascular involvement, it may cause inflammatory changes in various organs and body systems : digestive, respiratory, urinary, nervous and musculoskeletal. A case is reported of atypical Kawasaki disease associated with acute renal failure and necrotizing myositis in the right gastrocnemius in a 10-year-old...
Original Article
Usefulness of Low Risk Criteria for Serious Bacterial Infection Among Febrile Infants Younger than Three Months of Age
So Hyun Kim, Ji Ah Jung, Hae-Soon Kim, Eun Sun Yoo, Sejung Sohn, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 2002;45(8):967-972.   Published online August 15, 2002
Purpose : A retrospective study was undertaken to evaluate the usefulness of low risk criteria for identifying febrile infants younger than three months unlikely to have serious bacterial infection. Methods : We conducted a retrospective study of 527 infants younger than three month with a axillary temperature ≥37.4℃. If they met the following all four criteria, appear well, WBC 5,000- 20,000/mm3,...
A Clinical Manifestation of Meckel's Diverticulum
Jin Beom Lee, Yong Soon Lee, Eun Sun Yoo, Hae Soon Kim, Se Jeong Son, Eun Ae Park, Seung Joo Lee, Sun Hee Sung, Jeong Wan Seo
Clin Exp Pediatr. 2002;45(4):466-472.   Published online April 15, 2002
Purpose : The diagnosis of Meckel's diverticulum is difficult and delayed because it presents with various clinical symptoms. We evaluated clinical, imaging and pathologic findings of Meckel's diverticulum to facilitate detection of Meckel's diverticulum in children. Methods : Review of clinical, imaging, surgical and pathological findings in 10 children aged 7 days to 14 years with Meckel's diverticulum during an 8-year...
Case Report
A Case of Bilateral Spontaneous Tension Pneumothorax Associated with Mycoplasma pneumoniae Infection
Jae Won Lee, Mi Young Heo, Hae Soon Kim, Seung Joo Lee
Clin Exp Pediatr. 2002;45(3):401-405.   Published online March 15, 2002
Mycoplasma pneumoniae(M. pneumoniae) is the leading cause of pneumonia in school-age children and young adults. The clinical courses are usually mild but recently, severe cases were reported such as lung abscess, Swyer-James syndrome and adult respiratory distress syndrome. Spontaneous pneumothorax associated with M. pneumoniae infection is rare. Carlisle reported a 6-year-old patient with bilateral spontaneous pneumothorax associated with M. pneumoniae...
Original Article
The Utility of Serum Prealbumin as a Biochemical Marker for Nutritional Adequacy in Neonates
Ji A Jung, Eun Ae Park, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 2000;43(5):605-610.   Published online May 15, 2000
Purpose : The purpose of this study was to determine the utility of serum prealbumin as a biochemical marker for nutritional adequacy in neonates. Methods : From March 1998 to May 1999, 71 fullterm(54 AGA, 9 LGA, 8 SGA) and 46 preterm neonates were enrolled. The correlations among prealbumin, albumin, birth weight and gestational age were obtained. Serum concentrations of albumin...
Diagnostic Value of Urine Latex Test In Bacterial Meningitis
Seung Min Lee, Eun Ae Park, Seung Joo Lee
Clin Exp Pediatr. 2000;43(1):55-59.   Published online January 15, 2000
Purpose : Bacterial meningitis in childhood carries significant mortality and morbidity, so accurate and rapid diagnosis is important. Cerebrospinal fluid(CSF) latex agglutination test has been used for rapid diagnosis of bacterial meningitis. However, urine may be the best specimen for a latex test, because bacterial antigens are concentrated in the urine. The study tried to determine the diagnostic value of urine latex test in...
Case Report
Levamisole-Induced Reversible Agranulocytosis in Children with Steroid Dependent Nephrotic Syndrome
Su Jin Lee, Su Ja Hwan, Eun Seon Yoo, Seung Joo Lee
Clin Exp Pediatr. 1999;42(4):576-579.   Published online April 15, 1999
Levamisole has been used for nephrotic syndrome due to its immunostimulating, immunomodulating, and steroid-sparing effects. Agranulocytosis, a serious side effect of levamisole, was rare and mostly associated with autoimmune disease, neoplastic disease and HLA B27 except one case in a nephrotic syndrome who was treated with high-dose(5mg/kg QOD) levamisole. This 15 year-old girl with steroid dependent nephrotic syndrome, who was...
Original Article
The Risk Factors of Renal Scar in Childhood Acute Pyelonephritis
Soo Ja Hwang, Seung Joo Lee
Clin Exp Pediatr. 1999;42(4):545-552.   Published online April 15, 1999
Purpose : To observe the risk factors of renal scar in children with first acute pyelonephritis (APN) who had photopenic defects on initial 99mTc-DMSA spect renal scan. Methods : Forty-seven children with first APN(M : F=33 : 14) who were admitted to Ewha Womans University Hospital from September, 1993 to Febrary, 1998, were divided into renal scar group(N=17, Kidney unit(KU)=18) and...
The Utility of Serum Prealbumin Concentrations for Short-term Nutritional Assessment in Patients with Acute Diarrhea
Kyoung Ah Lim, Hae Soon Kim, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 1999;42(1):88-93.   Published online January 15, 1999
Purpose : To evaluate the usefulness of serum prealbumin concentration for the nutritional assessment of acute diarrhea. Methods : From February 1997 to August 1997, ninety patients with acute diarrhea(age, 4-24 months) were randomly assigned into two groups on the basis of their intakes for 2 days prior to admission : liquid diet group(N=56, clear liquid and/or oral electrolyte solutions), and...
Reference Values of Hematologic and Biochemical Parameters of Nutrition around Weaning Period
Seung Joo Lee, Jeong Wan Seo, Jae Ock Park, Jae Hoon Shin, Hae Ran Lee, Ji Tae Chung, Hae Il Chung
Clin Exp Pediatr. 1999;42(1):6-14.   Published online January 15, 1999
Purpose : To determine the reference values of hematologic and biochemical parameters of nutrition around the weaning period. Methods : From February 1996 to March 1997, several nutritional laboratory values were evaluated in 130 healthy babies and 120 inpatients in the recovery stage of acute illness at six general hospitals. Results : Reference values in 9-month-old healthy babies(range : 6-12 months) were...
Original Article
The Effect of Low-Dose Dopamine on the Renal Function of Asphyxiated Neonates
Seung Yeon Nam, Eun Ae Par, Seung Joo Lee
Clin Exp Pediatr. 1998;41(12):1685-1692.   Published online December 15, 1998
Purpose : Low-dose dopamine(0.5-3μg/kg/min) increases renal blood flow, glomerular filtration rate and natriuresis and has protective and therapeutic effects on oliguric renal failures. Asphyxia is the most common cause of acute renal failure in neonates. But the protective effects of dopamine have never been reported in asphyxiated neonates. So we reported the effects of low-dose dopamine on the renal function...
Case Report
A Case of Myositis Ossificans Progressiva
So Young Park, Su Jin Lee, Ji A Chung, Seung Joo Lee
Clin Exp Pediatr. 1998;41(11):1601-1605.   Published online November 15, 1998
Myositis ossificans progressiva(MOP) is a rare, slow progressive autosomal dominant disorder that principally affects children under the age 10 years. It is characterized by progressive fibroblastic proliferation, and subsequent calcification and ossification of subcutaneous fat, muscles, tendons, aponeuroses and ligaments. The disorder is often associated with symmetrical malformations of the digits, especially microdactyly or adactyly of the thumbs and great...
Original Article
The Clinical Significance of Serum Sodium Concentration in Febrile Convulsion
So Young Park, Seung Joo Lee
Clin Exp Pediatr. 1998;41(9):1262-1267.   Published online September 15, 1998
Purpose : Recently hyponatremia was reported to be common in febrile convulsion and related to the probability of a repeated convulsion. It was documented that hyponatremia lowers the threshold for convulsion in experiment animals. We therefore studied the relationship between hyponatremia and febrile convulsion. Methods : Serum sodium concentration was measured in 82 children with febrile convulsions and 66 age-matched febrile...
The Diagnostic Value of CSF Tumor Necrosis Factor-α for Early Diagnosis of Bacterial Meningitis
So Young Park, Soo Ja Hwang, Eun Ae Park, Jung Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 1998;41(8):1078-1083.   Published online August 15, 1998
Purpose : During the course of bacterial meningitis, TNF-α produced by macrophages and monocytes in response to LPS and other inflammatory and immune stimulation, is now recognized as a primary mediator in the pathogenesis of infection, injury and inflammation and in the process of host defence. TNF-α was increased vascular permeability by inducing morphologic and structural changes of endothelial cells...
Random Urine Ca/Cr Ratio in Healthy Neonates
Hea Young Lee, So Young Park, Eun Sun Yoo, Eun Ae Park, Seung Joo Lee
Clin Exp Pediatr. 1998;41(3):378-382.   Published online March 15, 1998
Purpose : Recently, in high risk preterm infants, we experienced high incidence of hypercalciuria, nephrolithiasis & nephrocalcinosis. To screen hypercalciuria, we need the normal value of random urine Ca/Cr ratio in healthy neonates according to gestational age, postnatal age, milk and calcium intake. Methods : Random urine Ca/Cr ratio was checked in 260 healthy full-term infants at the 2-7th day, and...
A Survey on the Factors Related to the Failure of Breast-feeding
Seung Joo Lee, Jeong Wan Seo, Jae Ock Park, Jae Hoon Shin, Hae Ran Lee, Ji Tae Chung, Hae II Chung
Clin Exp Pediatr. 1997;40(10):1336-1346.   Published online October 15, 1997
Objective : The breast-feeding rate has decreased in Korea despite of the active encouraging effort of breast-feeding for the last 10 years. So we investigated the factors that are related to breast-feeding failure. Method : 1807 specific questionares of mothers who visited the six university hospitals in Seoul from October 1993 to December 1995 were analysed by ANOVA and multiple logistic regression using SAS program. Results...
Case Report
An Autopsy Case of Tracheal Agenesis Type 2
Hyun Joo Lee, Eun Ae Park, Seung Joo Lee, Mi Jeong Kim, Soon Hee Seong
Clin Exp Pediatr. 1996;39(12):1759-1762.   Published online December 15, 1996
Tracheal agenesis is the rare and uniformly lethal anomaly that presents with severe respiratory distress and aphonia after birth. In this anomaly, the trachea is usually absent and air is reaching the bronchi through a communication with the esophagus. The diagnosis should be suspected in a nowborn infant with respiratory distress whose intubation is difficult. We report an autopy case of tracheal...
Original Article
The Risk Factors related to Recurrent Intussusception by Ultrasonography
Eun sun Yoo, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 1996;39(12):1707-1716.   Published online December 15, 1996
Purpose : We investigate the risk factors of recurrence after first intussusception. Methods : We have studied the relationship of the clinical features and ultrasonographic findings and the risk of recurrent intussusception in 97 patients with reduced intussusception including 22 recurrent intussusception who admitted at the department of pediatrics at Ewha Womans University Mok-dong hospital from September 1993 to Feburary 1996. Results...
Diagnostic Value of 99mTc-DMSA Renal Scan for Early Diagnosis of Acute Pyelonephritis in Children with Febrile Urinary Tract Infection
Soo Ja Hwang, Eun Ae Park, Jeong Wan Seo, Seung Joo Lee, Sun Whan Lee
Clin Exp Pediatr. 1996;39(11):1586-1593.   Published online November 15, 1996
Purpose : For prevention of renal scar, early diagnosis and treatement of acute pyelonephritis are important in children with febrile urinary tract infection. But it has been difficult to differentiate acute pyelonephritis from lower urinary tract infection. We have performed this study to evaluate the diagnostic value of 99mTc-DMSA renal scan and to clarify the relationship among acute pyelonephritis, vesico-ureteral reflux and renal scar. Methods...
The Effect of Allopurinolon the Ischemia-reperfusion RenalInjury in Young Rats
Seung Joo Lee
Clin Exp Pediatr. 1996;39(11):1576-1585.   Published online November 15, 1996
Objective : Oxygen free radicals has been reported to be the critical cellular mediators of experimental ischemia-reperfusion renal injury. We examined the protective effect of allopurinol (an xanthine oxidase inhibitor) on the renal damage by reperfusion in the ischemic rat kidney. Methods : To induce renal ischemia, the Sprague-Dawley rats(weight 70-80g) were placed in a sealed 5L jar with 8% O2-92% N2 gas mixture...
Arterial Oxygen Desaturation after Salbutamol Nebulization in Wheezy Infants and Children
Eun Sun Yoo, Jung Won Seo, Seung Joo Lee
Clin Exp Pediatr. 1996;39(7):953-961.   Published online July 15, 1996
Purpose : Nebulized selective β2-adrenoreceptor agonists have been widely used in acute asthma and selectively in acute bronchiolitis. However, nebulized salbutamol have been reported to cause arterial oxygen desaturation in some of the acute bronchiolitis and severe asthma patients. This may be the results of a paradoxical bronchoconstriction linked to acidic and hyper-osmolar nebulized salbutamol solution and etc. We assessed the changes in arterial...
Serum IgE Standardized for Age in Korean Children and Its Diagnostic Reliability in Childhood Asthma
Myung Su Lee, Eun Sun Yoo, Hye Sun Kim, Eun Ae Park, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 1996;39(3):397-403.   Published online March 15, 1996
Purpose : IgE was identified by Ishizaka as an antibody that is reacted at Type I hypersensitivity reaction, and has been used in the diagnosis of allergic disease and the differential diagnosis of extrinsic and intrinsic asthma. But there was some confusing in the diagnosis because of the broad range of measured serum IgE. Recently it was reported that serum IgE...
Special Infant Formula
Seung Joo Lee
Clin Exp Pediatr. 1996;39(2):180-186.   Published online February 15, 1996
Original Article
3 Cases of Kawasaki Disease Associated Thrombocytopenia
Hye Soon Kim, Young Mi Hong, Seung Joo Lee
Clin Exp Pediatr. 1995;38(12):1686-1690.   Published online December 15, 1995
Kawasaki disease may be associatde with a variety of hematologic abnormalities, the most characteristic being thrombocytosis. Thrombocytopenia, in contrast, appears to occur rarely in children with this disease. Hera et al observed the 2% manifested thrombocytopenia early in their illness. To our knowledge, early thrombocytopenia has not been reported in other populations, We report the case of a children with...
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