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Original Article
The effect of sucrose on infants during a painful procedure
Kyoung Hwa Joung, Soo Chul Cho
Clin Exp Pediatr. 2010;53(8):790-794.   Published online August 31, 2010

The purpose of this study was to test the efficacy of treating the pain among newborn infants associated with a medical procedure with sucrose with regard to overall physiological and behavioral stability.


103 newborn infants were enrolled in this study. The control group (n=63) did not receive any treatment. The experimental group (n=40) received 2 mL of 24% sucrose solution two...

Case Report
Joubert syndrome with peripheral dysostosis - A case report of long term follow-up -
Jung Tae Kim, Sun Jun Kim, Chan-Uhng Joo, Soo Chul Cho, Dae-Youl Lee
Clin Exp Pediatr. 2007;50(3):315-318.   Published online March 15, 2007
This report describes the long-term follow-up of a 10-year-old female patient with Joubert syndrome with short stature and brachydactyly. She presented with hyperpnea alternated with hypopnea, uncontrolled jerking eye movements, and hypotonia during early infancy. She was diagnosed with Joubert syndrome based on clinical symptoms and typical MRI findings at 5 months of age. Abnormal ventilation and eye movements disappeared...
Original Article
Comparision of PCR-RFLP, PCR-SSCP, Amplication Refractory Mutation System(ARMS) in Leu72Met Polymorphism of Ghrelin Gene
Ju Sung Kang, Se Rim Kim, Sun Young Kim, Chan Uhng Joo, Soo Chul Cho, Pyoung Han Hwang
Clin Exp Pediatr. 2005;48(10):1068-1075.   Published online October 15, 2005
Purpose : The role of ghrelin, which promotes the secretion of growth hormone, was not well known until now. Recently it was found that the mutation of ghrelin gene is related to obesity and diabetes. This study is to find the screening method that can easily and effectively detect the polymorphism of Leu72Met in ghrelin gene of obesity patients and...
Alteration of Growth Factor Expression after Acute Ischemic Renal Injury
Yang Sim Koe, Soo Yeon Lee, Won Kim, Soo Chul Cho, Pyoung Han Hwang, Jung Soo Kim, Dae-Yeol Lee
Clin Exp Pediatr. 2003;46(7):687-694.   Published online July 15, 2003
Purpose : Regeneration and repair after ischemic renal injury appears to be modulated by circulating or locally produced growth factors. This study examined the changes of serum insulin like growth factor(IGF-I) and renal expression of IGF-I and II, vascular endothelial growth factor(VEGF), transforming growth factor-β(TGF-β), and connective tissue growth factor(CTGF) during the active regeneration period after acute ischemic injury. Methods :...
Novel Gap Junction Molecules, Connexin 37, Enhances the Bystander Effect in HSVtk/GCV Gene Therapy
Sun Young Kim, Ho Keun Yi, Jung Chang Lee, Dong Jin Hwang, Pyoung Han Hwang, Dae Yeol Lee, Soo Chul Cho
Clin Exp Pediatr. 2003;46(6):541-547.   Published online June 15, 2003
Purpose : Gap junction intercellular communication(GJIC) is an important mechanism of the bystander effect in herpes simplex thymidine kinase/ganciclovir(HSVtk/GCV) gene therapy Therefore, we attempted to enhance the bystander effect in vitro by exogenous overexpressing connexin 37(Cx37) in cells to increase GJIC. Methods : NIH3T3 cells were transfected with the Cx37 and HSVtk gene or the HSVtk gene alone by the calcium...
Electrocardiographic and Echocardiographic Characterisitics of Wolff-Parkinson-White Syndrome in Preschool Children
Jeoung Min Chu, Hyun Sup Sim, Soo Chul Cho, Chan Uhng Joo
Clin Exp Pediatr. 2002;45(9):1097-1105.   Published online September 15, 2002
Purpose : This study was conducted to estabilish the prevalence, clinical features and relationship between ECG findings and echocardiographic findings of Wolff-Parkinsion-White(WPW) syndrome in asymptomatic preschool children. Methods : An electrocardiographic screening study was performed on 77,824 preschool children in Jeonbuk province from April, 1999 to August, 2001. Patients with WPW syndrome underwent echocardiographic study. Results : Twenty three patients with WPW...
Effect of Antiepileptic Drugs on Bone Metabolism and Growth in Epileptic Children
Woo Suk Juhng, Sun Jun Kim, Soo Chul Cho, Chan Uhng Joo
Clin Exp Pediatr. 1999;42(8):1078-1085.   Published online August 15, 1999
Purpose : Long-term administration of anticonvulsants for children with convulsive disorder may cause osteomalacia, depending on dosage, duration, types, and combination of anticonvulsants administered. This study was performed to examine the effect of anticonvulsant drugs on bone mineral density in epileptic children. Methods : Forty-eight epileptic children aged 3 to 15 years were enrolled in this study. They were treated with...
Case Report
Removal of a Displaced Catheter from Upper GI Tract of a Newborn Using a Goose Neck Snare
Chan Uhng Joo, Jae Ho Song, Soo Chul Cho
Clin Exp Pediatr. 1999;42(3):442-445.   Published online March 15, 1999
For the immediate proper respiratory care of a delivered newborn, the face is wiped immediately, and the mouth and nares should be suctioned. A soft rubber syringe or soft rubber catheter is suitable for suctioning. If respirations are infrequent, suction of the mouth and pharynx serves to stimulate breathing. We experienced a case of a foreign body in the distal...
Original Article
Profile of Insulin, Growth Hormone and Insulin-like Growth Factors in Human Cord Blood According to Birth Weight
Hye Young Kim, Dae Yeol Lee, Soo Chul Cho
Clin Exp Pediatr. 1998;41(11):1484-1490.   Published online November 15, 1998
Purpose : Insulin-like growth factors(IGFs) are mitogenic peptides that are essential for fetal and maternal tissue growth during pregnancy. They circulate primarily with serum IGF-binding protein(IGFBP) which regulates the availability of IGFs to their specific target tissue. This study was performed to examine the relationships between birth weight and IGFs, insulin and growth hormone in the sera of cord blood...
The Study of Transplacental Transfer of Immunoglobulin G in Premature Infants
Sung Soo Moon, Yoon Ki Kang, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1998;41(6):747-753.   Published online June 15, 1998
Purpose : Premature infants have low serum immunoglobulin G(IgG) levels because IgG is transplacentally acquired, primarily after 32-34 weeks of gestational age. We studied the transplacental transfer of serum IgG in preterm infants. Methods : The IgG levels in the sera were measured by radial immunodiffusion method(Behring nephelometer, Germany). Results : There was a significant difference between IgG concentration and gestational age; the IgG concentration increased...
Changes of Anti-H.influenzae Type b IgG in the Sera of Korean Infants and Children after Birt
Jong Man Park, Keoung Hie Moon, Kyung Mee Lee, Sun Jun Kim, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1997;40(2):181-188.   Published online February 15, 1997
Purpose : Most of invasive Haemophilus influenzae diseases occur in children under 5 years of age, and are due almost exclusively to type b strain. Although antibodies to several surface antigens of H.influenzae play a role in conferring immunity, antibody to the type b capsular polysaccharide appeared to have the most important protective functions. However, the antibody response to vaccines or natural...
Placental Transfer of Anti-H. influenzae Type b Specific IgG and IgG Subclasses
Soo Hee Chang, Moon Hwan Lee, Pyoung Han Hwang, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1995;38(12):1638-1644.   Published online December 15, 1995
Purpose : Haemophilus injluenzae type b (Hib) is one of the most important causes of invasive bacterial diseases in infants and children. In Korea, however, the proportion occupied by Hib as a cause of pediatric pathogen seems to be less compared to those of western countries. This study was performed to provide the epidemiologic and immunologic basis of H influenzae type...
Case Report
A Case of the Renal Artery Aneurysm Associated with the Dysplastic Kidney
Tae Hee Park, Soo Hee Chang, Young Min Han, Soo Chul Cho, Dae Yeol Lee
Clin Exp Pediatr. 1995;38(11):1571-1576.   Published online November 15, 1995
Multicystic dysplastic kidney is the most frequent cause of abdominal mass in the neonate. It is frequently associated with contralateral genitourinary tract abnormalities and the most common abnormality is vesicoureteral reflux. Renal artery aneurysm is very rare in the children. Furthermore the case associated with the renal artery aneurysm has not been reported yet. We experienced a case of the left...
A Case Report of Acrorenal Syndrome
Soo Hee Chang, Jo Seph Choi, Soo Chul Cho, Dae Yeol Lee
Clin Exp Pediatr. 1995;38(8):1151-1154.   Published online August 15, 1995
Acrorenal syndrome is congenital anomaly of the limbs and urinary tract of unknown etiology. Acral malformations consist of varying combinations of oligodactyly, ectrodactyly, syndactyly, brachydactyly, polydactyly, and carpal, tarsal, or metatarsal fusions of the hands and feet. Urinary tract abnormalities include unilateral renal agenesis and duplication of the collecting system. The condition is a polytopic developmental field defect(acrorenal field) and...
Original Article
The Effect of Milk on the Bioavailability of 6-mercaptopurine
Sun Kyu Park, Ran Ju Kim, Pyoung Ha Hwang, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1994;37(12):1732-1737.   Published online December 15, 1994
The purine antimetabolite 6-Mercaptopurine (6-MP) has been in clinical use for over 30 years and is still a widely used agent in the treatment of childhood acute lymphoglastic leukemia. The bioavailibility, clinical effecacy and toxicity of 6-MP administered orally for maintenance therapy of children with acute lymphoblastic leukemia are highly variable in many studies, as well as at different times...
Medical Lecture Course
Bronchopulmonary Dysplasia
Soo Chul Cho
Clin Exp Pediatr. 1994;37(5):587-595.   Published online May 15, 1994
Case Report
A Case of Congenital Tricuspid Stenosis
Chan Uhng Joo, Soo Young Cho, Soo Chul Cho
Clin Exp Pediatr. 1993;36(5):733-736.   Published online May 15, 1993
Congenital tricuspid stenosis is ancommon congenital heart anomaly. Tricuspid stenosis is usually associated with other anomalies, most commonly severe pulmonary stenosis or atresia with secondary hypoplasia of the right ventricle. Clinically it may be difficult to distinguish from tricuspid atresia. A case of congenital tricuspid stenosis in a 32 day-old-girl is presented. The patient had cyanosis and dyspnea. Echocardiographic study revealed...
Original Article
A study on the immune reaction to the milk protein antigens in the postpartum mother, newborn baby, and children.
Soo chul Cho, Ju Hyung Kim, Hong Ro Lee, Jong San Lee, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1991;34(11):1547-1558.   Published online November 30, 1991
There is continuing interest in the isotype response of human serum antibodies reactive with dietary proteins. This study was performed to clarify the humoral immune responses against cow’s milk proteins, 分-lactoglobulin and a-lactalbumin. Milk protein specific IgG, IgA, IgM, and IgG subclasses were measured using ELISA in the blood of various groups of age. The results were as follows: 1) Milk protein specific immunoglobulins were higher...
Changes of Specific Immunogloblins Against Dihperia Toxoid After DPT Vaccination.
Byung Sook Park, Byung An Shim, Kyung Jin Shin, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1988;31(9):1126-1132.   Published online September 30, 1988
The present study was performed to define the humoral immune responses after DPT vaccination changes of diphteria specific IgG and IgM were evaluated suing ELISA method on 196 cases of 6 groups which were divided according to the frequency of DPT vaccination. Alum-precipitated diphtheria toxoid was used as antigen for ELISA. The results were as follows; 1) IgG was mainly involed in humoral immune responses against...
A Study on the Renal Function in Neonates and Children.
In Soo Choi, Young Sook Kim, Soo Chul Cho, Jung Soo Kim, Kyung Woo Cho
Clin Exp Pediatr. 1983;26(8):744-750.   Published online August 31, 1983
A study on the renal function and its changes by aging in neonates and children has been done, and the result obtained were as follow. 1) Urinary output, creatinine and electrolyte excretion in neonates (age: 12 〜 24 hrs) were significantly lower than children over 1 〜2 yrs, and urine concentrating ability may not yet t>e matured. 2) Urinary output, creatinine and electrolyte excretion in children...
The Effects of Phenobarbital and Theophylline on the Phagocytic Function of Reticuloendothelial System of Rats.
Soo Chul Cho, Hyun Suk Lee, Kyu Cha Kim, Ho Yeul Choi
Clin Exp Pediatr. 1982;25(6):554-559.   Published online June 30, 1982
This experiment was carried out to investigate the effects of depressor and stimulator of central nervous system on the reticuloendothelial phagocytic function in vivo. The phagocytic activity was assessed by means of carbon clearance method after intra-muscular adimnistration of phenobarbital(1mg/0.2 ml of normal saline/100 gm of body weight) and intravenous administ-ration of theophylline(1 mg/0.2 ml of normal saline/100 gm of...
Case Report
A Cases of Patent Urachus.
Dae Yool Lee, Soo Chul Cho, Kyu Cha Kim
Clin Exp Pediatr. 1981;24(3):275-279.   Published online March 15, 1981
Patent urachus occurs when there is a primary failure of luminal closure of the urachus, so a communication between the urachus and both the bladder and the umbilicus exists. Urachal anomalies are exceptionally rare occurrences that may manifest themselves in later life as well as in childhood and at first, patent urachus was reported by Cabrolius in 1550. Patent urachus...
Nursing Bottle Caries.
Dae Yeol Lee, Soo Chul Cho, Jung Soo Kim, Kyu Cha Kim
Clin Exp Pediatr. 1980;23(7):582-585.   Published online July 15, 1980
Feeding habits and sugar contents contents affect dental health and ultimately the total health of young chidren. Nursing bottle caries, nursing botte syndreme, bottle-propping caries are synonymous term for a devastaing condition that may render young children dental cripples. Typically, the primary maxillary incisors are affected most severely and mandibular incisors are seldom involved. We report 4 cases of nursing...
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