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Volume 40(12); Dec 1997
Medical Lecture Course
Localization of Epileptogenic Regions in the Very Young Children with Intractable Seizures
Kon Hee Lee
J Korean Pediatr Soc. 1997;40(12):1633-1638.   Published online December 15, 1997
Clinical Lecture
Pediatric Ocular Disorders
Young Suk Yu
J Korean Pediatr Soc. 1997;40(12):1639-1644.   Published online December 15, 1997
Original Articles
The Prevalence of A985G Mutation in Medium Chain Acyl-Coenzyme A Dehydrogenase(MCAD) Gene in Neonates Determined from Guthrie Card
Baeck Hee Lee, Hye Won Park, Moon Soo Park, Ho Jin Park, Yong Choi, Hae Il Cheong
J Korean Pediatr Soc. 1997;40(12):1645-1650.   Published online December 15, 1997
Purpose : Medium chain acyl-CoA dehydrogenase(MCAD) deficiency is an autosomal recessive disoder of β oxidation of fatty acids and characterized by episodic hypoglycemia, vomiting, convulsion, encephalopathy, apnea, and sudden death related to fasting or infection resembling Reye syndrome or sudden infant death syndrome. In acute stage, mortality rate is very high and survivors have significant risk of developmental disability and chronic somatic illness. However,...
The Significance of Increased Circulating Intercellular Adhesion Molecule 1(cICAM-1) in Neonatal Sepsis
Hai Lee Chung, Eun Jung Park, Young Ho An, Jin Bok Hwang, Chang Ho Han, Young Dae Kwon, Sang Gyoung Kim
J Korean Pediatr Soc. 1997;40(12):1651-1659.   Published online December 15, 1997
Purpose : The early and efficient diagnosis of neonatal sepsis still remains a difficult task. Reliable laboratory test is not available yet and treatment is mainly based on the physical appearance of infants. And high number of negative blood cultures in cases of clinically diagnosed sepsis further emphasize the need for a more reliable index for early diagnosis. Intercellular adhesion molecule 1(ICAM-1) has been...
The Espression of Fcγ Receptors and Mac-1 in Cord and Adult Blood Monocytes and Lymphocytes and Production of Interleukin-8 by Cord and Adult Blood Mononeuclear Cells Stimulated by Lipopolysacchride
Kyung Hyo Kim, Gyoung Hee Kim
J Korean Pediatr Soc. 1997;40(12):1660-1669.   Published online December 15, 1997
Purpose : The immature neonatal immune system is thought to result in increased risk of infection. Receptors for the Fcmoiety of IgG(FcγR) are important in antibodymediated clearance of microbes by monocytes/macrophages and immune regulation in lymphocytes. As an approach to understanding their role in neonatal life, we have compared the constitutive expression of the three Fc receptors-FcγRI(CD64), FcγRII(CD32) and FcγRIII(CD16)-by neonatal and adult blood monocytes...
The Correlation between a Semi-quantitative ASO(Antistreptolysin O) Assay by Rantz-Randall and a Quantitative ASO Assay by Nephelometry
Sung-Keun Park, Seok-Hee Ahn, Jung-Woo Lee, Byoung-Soo Cho, Sung-Ho Cha, Yong-Mook Choi
J Korean Pediatr Soc. 1997;40(12):1670-1674.   Published online December 15, 1997
Purpose : Accurate diagnosis and prompt treatment of infection with Streptococcus pyogenes (group A streptococci) is required as it may cause many complications, and chronic serious sequelae, acute rheumatic fever and acute glomerulonephritis. Recently, the assay methods of ASO concentration tend to be changed into quantitatively from semi-quantitative or qualitative methods in this country. We would like to know relationships and degree of concurrences between...
Postoperative Weight-Gain in Early Infants with Symptomatic Large Ventricular Septal Defect
Chang-Rang Kang, Hyang-Suk Yoon, Jong-Bum Choi, Soon-Ho Choi
J Korean Pediatr Soc. 1997;40(12):1675-1680.   Published online December 15, 1997
Purpose : To investigate the postoperative patterns of weight-gain in early infants with ventricular septal defects(VSDs), we analyze 48 patients who received primary surgical closure of the symptomatic VSDs during 6 months of age in the period of 1993 through 1995. Methods : Forty-sixt infants met criteria for inclusion in the study. The mean follow up period was 14 months(3 to 36 months). Weight...
Diagnostic and Therapeutic Efficacy of Endoscopic Retrograde Cholangiopancreatography in Children
Kyung Mo Kim, Ho Soon Choi, Sung Koo Lee, Myung Hwan Kim, Chong Hyun Yoon, Dong Myung Lee
J Korean Pediatr Soc. 1997;40(12):1681-1691.   Published online December 15, 1997
Purpose : Endoscopic retrograde cholangiopancreatography(ERCP) may provide more definite diagnosis, preoperative guidance, and endoscopic therapy in many children with known or suspected disorders of the pancreas and biliary tract. But the reports about the ERCP in children are rare, so this study is conducted to evaluate the indication, efficacy and safety of the ERCP in children. Methods : Twenty nine ERCPs in 19 children...
Follow-Up Study of Urinary Tract Infection Associated with Vesicoureteral Reflux
Do Whan Kil, Jea Eun Lee, Wan Seob Kim
J Korean Pediatr Soc. 1997;40(12):1692-1700.   Published online December 15, 1997
Purpose : Vesicoureteral reflux(VUR) is the major cause of urinary tract infection (UTI) in children. Prolonged untreated UTI associated with VUR may result in serious complications, such as renal scarring, renal atropy, and decreased renal function. Therefore, follow up must be continued until UTI is cured completely, to prevent of serious complication. The authors conducted this study to evaluate results of the follow-up of...
A Study of Serum Cytokines in Nephrotic Syndrome
Mea Young Chang, Jae Ho Lee
J Korean Pediatr Soc. 1997;40(12):1701-1706.   Published online December 15, 1997
Purpose : It has been reported that patients with nephrotic syndrome have high serum IgE value and IL-4 involve in IgE synthesis, IL-6 is an autocrine growth factor for the proliferation of mesangial cells. We studied association between serum cytokines and of nephrotic syndrome. Methods : We measured serum IL-6, IL-4, IFN-Υ, CD23 in 14 children with nephrotic syndrome and 3 healthy children by...
A Result of Treatment of Malignant Germ Cell Tumors in Childhood
Hyoung Jin Kang, Jun Ah Lee, Hyo Jeong Han, Hyoung Su Choi, Hyeon Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn, Kwi Won Park, Byung Keu Cho, Hwang Choi, Chul Woo Kim
J Korean Pediatr Soc. 1997;40(12):1707-1718.   Published online December 15, 1997
Purpose : Germ cell tumors have variable clinical characteristics according to the age, sex, primary site, and pathologic diagnosis. To provide the therapeutic principle, the clinical characteristics, response to the treatment, and prognostic factors were analyzed. Methods : Medical records of 57 children who were diagnosed as malignant germ cell tumor in Seoul National University Children' s Hospital from January 1986 till June 1996 were...
Effect of GCV on Neuroblastoma Cell Line Expressed by HSV-TK Gene with Retroviral Vector
Hyun Sang Cho, Chuhl Joo Lyu, Yeun Soo Kim, Tae Soo Kim, Byung Soo Kim
J Korean Pediatr Soc. 1997;40(12):1719-1724.   Published online December 15, 1997
Background : Gene transfer with vectors derived from murine retroviruses is restricted to cells which are proliferating and synthesizing DNA at the time of infection. Accordingly, selective introduction of genes encoding for susceptibility to otherwise nontoxic drugs(suicide genes) into proliferating tumor may be used to treat cancer. We investigated the efficacy of in vitro transduction of neuroblastoma cell with the herpes simplex-thymidine kinase(HSV-tk) gene followed...
The Psychological Recognition of Asthmatic Childrenfrom Parents'Views
Nog Hong Kim, Eun Ieong Seol, Gi Hyon Jeon, Gyung Ho Lee, Mun Gi Cho, Cheoln Son
J Korean Pediatr Soc. 1997;40(12):1725-1730.   Published online December 15, 1997
Purpose : Many studies showed that the asthmatic children mostly have psychosocial problem such as depression or anxiety. The object of this study is to help the asthmatic children and their family by knowing what is their mothers‘ biggest concern about their asthmatic children. Methods : We made up a questionnaire with asked the mothers by telephone. If they though asthma had a certain effect...
The Clinical Aspects of Septic Arthritis in Children
Milim Koo, Dongsoo Kim
J Korean Pediatr Soc. 1997;40(12):1731-1744.   Published online December 15, 1997
Purpose : Acute septic arthritis in infancy and childhood is uncommon. Delay of diagnosis and inappropriate treatment of septic arthritis results in permanent physical sequelae. We studied the initial treatment, clinical manifestations, involved sites, and etiologic organisms of septic arthritis. Methods : We reviewed 74 patients who were diagnosed septic arthritis in Departments of Pediatrics and Orthopedic Surgery, Yonsei University College of Medicine from July 1986...
Case Reports
A Case of Lipoid Pneumonia with Hypercalcemia Caused by SqualelneⓇ Intake by Force
Young Kyoun Kim, Ho Suk Kang, Seung Cheol Lee, Chong Guk Lee, Sang Woo Kim
J Korean Pediatr Soc. 1997;40(12):1745-1749.   Published online December 15, 1997
Lipoid pneumonia is a chronic, interstitial, proliferative inflammation resulting from aspiration of lipoid material and occurs principally in debilated infants. We experienced a case of lipoid pneumonia with hypercalcemia in a 15 month-old boy who showed irritability, poor weight gain, cough, dyspnea, fatigue, diarrhea and pale face after ingestion of SqualeneⓇ(shark liver oil : 20-30 cap/day) by force for 2 months. Calcium preparation was also...
Protein Losing Entropathy Due to TB Enterocolitis was Detected by 99mTc-Human Serum Albumin Scan
Hyoung No Kim, Jae Won Huh, Sang Gun Bee, Yong Woon Back, Chang Hyun Lee
J Korean Pediatr Soc. 1997;40(12):1750-1755.   Published online December 15, 1997
Protein losing entropathy was a secondary disorder of the gastrointestinal tract, which is associated with lymphatic obstruction, inflammatory and noninflammatroy disease. It' s clinical manifestations were abdominal pain, edema, diarrhea and growth failure. We described a 12-year-old boy, who had chronic diarrhea for 3 months and edema of lower extremities for 7 days. He also had severe hypoalbuminemia, iron definency anemia, liver diseases and malnurition,...
A Case of von Gierke Disease
Young A Joe, Moon Young Song, Bin Cho, Soon Ju Lee, In Kyung Sung, Kyong Su Lee
J Korean Pediatr Soc. 1997;40(12):1756-1760.   Published online December 15, 1997
von Gierke disease(type Ia glycogen storage disease) is an inherited disease associated with accumulation of glycogen in the liver, kidney, intestine and erythrocytes due to the defect of glucose-6-phosphatase activity. Hepatomegaly, doll face, anemia, bleeding tendency and increased susceptability to infection are common features observed during infancy. Hypoglycemia especially fasting hypoglycemia is typical metabolic derangement in this disease, followed by metabolic acidosis, lactic acidemia, hyperlipidemia, hyperuricemia,...
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