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Volume 42(11); Nov 1999
Clinical Lecture
Congenital Malformation of Musculoskeletal System : A Classification and Clinical Manifestations
In Ho Choi
J Korean Pediatr Soc. 1999;42(11):1479-1486.   Published online November 15, 1999
Original Articles
Characteristics of Transient Hypothyroidism Detected by Neonatal Screening Test
Su-Yung Kim
J Korean Pediatr Soc. 1999;42(11):1487-1495.   Published online November 15, 1999
Purpose : To help differentiate transient hypothyroidism from congenital hypothyroidism, both of which might be confused initially, the clinical characteristics of transient hypothyroidism were compared to those of permanent ones. Methods : An analysis of the clinical data, including perinatal history, TFT(thyroid function test), and radionuclide scanning, was performed. The outcome of 18 patients of transient hypothyroidism was also compared to...
Changes in Arterial Blood Gas in Crying Neonates
Yeo Hyang Kim, Heng Mi Kim
J Korean Pediatr Soc. 1999;42(11):1496-1501.   Published online November 15, 1999
Purpose : Arterial blood gas and pH measurements are the standard by which adequacy of oxygenation and ventilation are assessed. The major problem with arterial punctures is that they can rarely be done without disturbing the neonates. Crying during arterial puncture usually results in change in respiratory patten and thus may result in significant changes in blood gas values Methods :...
Tuberculin Response in Infants after BCG Vaccination during Neonatal Stage
Jeong Hee Kim, Dae Hyun Lim, Byung Kwan Son, Sei Woo Chung,, Jeong Gyu Kim, Seung Yeon Nam, Sang Il Lee, Jin A Son
J Korean Pediatr Soc. 1999;42(11):1502-1507.   Published online November 15, 1999
Purpose : Mantoux test was widely used to identify the tuberculosis. But no reliable method exists for distinguishing tuberculin reactions caused by previous BCG vaccination from those caused by mycobacterial infections. So we studied Mantoux response in infants who had received BCG vaccination in the first month of life. Methods : Mantoux testing was carried out in 143 healthy infants...
Study on Closing Time after Indomethacin Administration in Prematurity with Patent Ductus Arteriosus
Wan Cho, Suk Min Choi, Kyu Hyung Lee
J Korean Pediatr Soc. 1999;42(11):1508-1515.   Published online November 15, 1999
Purpose : In the clinical field, the closing time of patent ductus arteriosus(PDA) varies among patients after indomethacin administration. We tried to predict it by analyzing related factors, and also by understanding what affects it. Methods : Among 30 cases of PDA at the NICU, 24 cases(male 14 cases, female 10 cases) were selected. Fifteen cases closed early(within 36 hours) and...
Implication of vacA s1 Genotype of Helicobacter pylori in Children
Yae Jean Kim, Hae Young Park, Mi Ae Lee, Jeong Wan Seo
J Korean Pediatr Soc. 1999;42(11):1516-1523.   Published online November 15, 1999
Purpose : Recently vacA s1 genotype of Helicobacter pylori was known to be associated with enhanced inflammation and peptic ulceration. To evaluate the association of the vacA s1 genotype with enhanced inflammation and peptic ulceration in children, we performed a polymerase chain reaction(PCR) for vacA s1 genotype. Methods : Twenty-seven CLO test-positive children were enrolled. They also revealed histological detection...
Comparison Study between Immunohistochemical Staining and Enzyme Linked Immunosorbent Assay in Metalloproteinases and Tissue inhibitor of Metalloproteinases in Virus induced Myocarditis
Young Mi Hong, Seung Sook Kim
J Korean Pediatr Soc. 1999;42(11):1524-1534.   Published online November 15, 1999
Purpose : Most tissue disruption of extracellular matrix is mediated by extracellular proteinases. Matrix metalloproteinases(MMP) and tissue inhibitor of matrix metalloproteinases(TIMP) are associated with wound healing and repair. There has been no study done on MMP and TIMP in myocarditis. Methods : Coxsackie B virus(4,000 plaque forming unit) was injected into Balb/c mice by intraperitoneal injection. Histopathological finding was observed...
Atrial Rhythms in Patients with Left Atrial Isomerism
Jae Kon Ko, Young Mee Suh, Young Hwee Kim, In Sook Park, Chang Yee Hong
J Korean Pediatr Soc. 1999;42(11):1535-1541.   Published online November 15, 1999
Purpose : Histologic studies have revealed ectopic location and hypoplasia of sinus nodal tissue in left atrial isomerism. The purpose of this study is to characterize the atrial rhythms corresponding to these histologic abnormalities in left atrial isomerism. Electrocardiograms in left atrial isomerism are characterized by multiple atrial rhythms with abnormal P-wave axes, but the complex nature of atrial rhythms...
Effects of Hyperthermia on Neuronal Nitric Oxide Synthase Expression after Cerebral Ischemia in Gerbils
Doo Kwun Kim, Duk Joon Suh
J Korean Pediatr Soc. 1999;42(11):1542-1551.   Published online November 15, 1999
Purpose : This study was aimed to elucidate the effect of hyperthermia on neuronal nitric oxide synthase(nNOS) expression in both cerebral hemispheres after left common carotid artery occlusion in gerbils. Methods : Using Mongolian gerbils, cerebral ischemia was produced by occluding carotid artery for 1-4 hours. Rectal temperature was maintained at 36℃ for normothermia and 40℃ for hyperthermia by heating pad....
Therapeutic Effect of Nimodipine in Neonatal Rat Model of Cerebral Hypoxia-Ischemia
Ihn-Hee Hong, Heng-Mi Kim
J Korean Pediatr Soc. 1999;42(11):1552-1558.   Published online November 15, 1999
Purpose : Recent studies suggest that nimodipine, a potent calcium-channel blocker, may improve neurological outcome after experimental hypoxia-ischemic brain injury. This study was conducted to evaluate the therapeutic effect of nimodipine on hypoxia-ischemia in immature rat brain. Methods : Seven-day postnatal rats were subjected to hypoxia-ischemia by unilateral common carotid artery occlusion combined with 2 hours of hypoxia(in 8% oxygen...
Side Effects of Antiepileptic Drug in Children
Ick-Jin Song, Sang-Ook Nam
J Korean Pediatr Soc. 1999;42(11):1559-1566.   Published online November 15, 1999
Purpose : The purpose of this study is to estimate the side effects of antiepileptic drug(AED) in children. Methods : Subjects were 267 children who had received AED for at least 1 month during January 1995 to July 1998. We reviewed their sex, age at start of seizure onset, age at medication, class and number of AED, developmental delay, type and...
Hemostatic Changes and Effect of Antithrombin Ⅲ Replacement Therapy in Children with Acute Lymphoblastic Leukemia
Jeong Ah Choi, Young Tak Lim
J Korean Pediatr Soc. 1999;42(11):1567-1573.   Published online November 15, 1999
Purpose : We evaluated plasma coagulation parameters sequentially and the influence of antithrombin Ⅲ adjuvant treatment in children with acute lymphoblastic leukemia. Methods : Twenty-nine cases with acute lymhoblastic leukemia who had been treated with L-asparaginase at Pusan National University Hospital were enrolled in this study. The coagulation parameters were checked before and on every week of L-asparaginase administration. The...
Case Reports
Dapsone in a Case with Chronic Recurrent Henoch-Schönlein Purpura
Jin Choi, Soo Jung Lee, Dae Kyun Koh
J Korean Pediatr Soc. 1999;42(11):1574-1578.   Published online November 15, 1999
The most clearly delineated condition with prominent cutaneous leukocytoclastic vasculitis which presents to a pediatrician is Henoch-Schönlein purpura. There is general agreement that in Henoch-Schönlein syndrome the skin manifestations have a very benign long-term course and that corticosteroids are of little value. Dapsone appears to be of special value in diseases characterized by an accumulation of polymorphonuclear neutrophils notably leukocytoclastic...
Transcatheter Coil Embolization in the Treatment of Coronary Artery Fistula
S. J. Kim, I. S. Park, S. H. Lee, M. Y. Hann, D. J. Cho, E. J. Bae, S. H. Kim, Y. M. Kim
J Korean Pediatr Soc. 1999;42(11):1579-1582.   Published online November 15, 1999
Coronary artery fistulas, though relatively rare, are the most common hemodynamically significant congenital anomalies of the coronary artery system. Conventional surgical repair has been performed by either ligating the anomalous coronary connection or by direct closing of the Astula's orifice in patients undergoing a cardiopulmonary bypass. More recently, transcatheter embolization of fistulas, either with detachable balloons or coils, has been...
A Case of Infantile Marfan Syndrome
Sun Young Kim, Hee Ju Park
J Korean Pediatr Soc. 1999;42(11):1583-1588.   Published online November 15, 1999
Marfan syndrome is infrequently diagnosed early in infancy. The morphologic characteristics and prognosis in infantile Marfan syndrome may be quite different from those in older patients. Characteristic cardiac findings in early life include mitral valve prolapse, valvular regurgitation, and aortic root dilation. Morbidity and mortality may be high for infants diagnosed with Marfan syndrome. Cardiac surgery for cardiovascular complication in...
A Case of Parry-Romberg Syndrome in Neonate
Chun Hyuk Chang, Jin Hwa Jung, Sung Min Cho,, Dae Seop Choi
J Korean Pediatr Soc. 1999;42(11):1589-1593.   Published online November 15, 1999
Parry-Romberg syndrome(Progressive hemifacial atrophy), described in the last century by Parry(1825) and Romberg(1846), is a very rare disorder characterized by a slowly progressive and self-limited unilateral(rarely bilateral) atrophy of the faces affecting variably the skin, subcutaneous fat tissues, musculature, connective tissue, cartilage and bones. And this disorder is usually accompanied by contralateral Jacksonian epilepsy, trigerminal neuralgia, and changes in the...
A Case of Toxic Epidermal Necrolysis in Early Infancy
Min Seong Kim, Jeong Nyun Kim, Bang Soon Kim, Hong Joo Kim, Myung Jae Chey, Churl Young Chung
J Korean Pediatr Soc. 1999;42(11):1594-1598.   Published online November 15, 1999
Toxic epidermal necrolysis(TEN) is a bullous disorder affecting mainly basal layers of epidermis by hypersensitive reaction. It is rarely reported in infants under six months of age. It can be developed by drug, infection, and vaccination, which makes it difficult to differentiate from staphylococcal scalded skin syndrome(SSSS) especially in early infancy. We report a case of TEN in a 6-week-old...
A Case of Primary Small Cell Bronchogenic Carcinoma Detected by Bronchoscopy in a Child
Seon Ju Song, Chang Keun Kim, Churl Young Chung
J Korean Pediatr Soc. 1999;42(11):1599-1603.   Published online November 15, 1999
While the frequency of primary carcinoma of the lung has recently increased in adults, it is rare in the pediatric age group. The various adult types of bronchogenic carcinoma such as squamous cell, small cell, large cell, and adenocarcinoma, are extremely rare in children. Twenty to 30 cases of primary bronchogenic carcinoma of the lung in children under 15 years...
A Case of Persistent Left Superior Vena Cava Detected on Fetal Echocardiography
Jin Lee, Young-Yoo Kim, Youn-Soo Lee, Jong-Chul Shin, Jong-Wan Kim, Chung-Sik Chun, Kyung-Tai Whang
J Korean Pediatr Soc. 1999;42(11):1604-1609.   Published online November 15, 1999
We experienced a case of persistent left superior vena cava draining into the common atrium in a fetus of 26-year-old primigravida. Persistent left superior vena cava is derived from the left cardinal vein. This anomalous vessel usually drains into the right atrium via the coronary sinus and has no physiologic significance. Much less frequently, the left superior vena cava drains...
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