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Volume 43(11); Nov 2000
Clinical Lecture
Clinical Approaches to Genetic Disorders
Jin Sung Lee
J Korean Pediatr Soc. 2000;43(11):1413-1417.   Published online November 15, 2000
Original Articles
Tuberculin Reactivity to 2 TU of PPD RT23 Following Intradermal BCG Vaccination in Neonates
Jong Hwa Lee, Sung Hee Oh
J Korean Pediatr Soc. 2000;43(11):1418-1422.   Published online November 15, 2000
Purpose : 2 TU of PPD RT23 has been substituted for 5 TU of PPD RT23 since 1998 in Korea without adequate evaluation. This study was undertaken to evaluate the tuberculin reactivity to 2 TU of PPD RT23 following intradermal BCG vaccination in neonates. The results were compared with the previous report generated with 5 TU of PPD RT23 in...
Immunologic Characteristics of CATCH 22 Syndrome
Hye Young Ryu, Eun Kyung Jo, Eun Jung Cheon, Hong Ryang Kil, Jae Ho Lee
J Korean Pediatr Soc. 2000;43(11):1423-1429.   Published online November 15, 2000
Purpose : Microdeletion of chromosome 22q11.2 are associated with DiGeorge syndrome(DGS), velocardiofacial syndrome(VCFS) and conotruncal anomaly face syndrome(CTAFS). DGS was originally described as an immunodeficiency disorder secondary to impaired T cell production due to thymic aplasia or hypoplasia. But the frequency & severity of immunodeficiency of other clinical syndromes associated with the chromosome 22q11 deletion has not been investigated. This...
Effects of Partial Liquid Ventilation on Gas Exchange, Hemodynamics, and Pulmonary Function in Newborn Piglet with Respiratory Distress
Yun Sil Chang, Won Soon Park
J Korean Pediatr Soc. 2000;43(11):1430-1439.   Published online November 15, 2000
Purpose : To evaluate gas exchange, hemodynamics and pulmonary function during partial liquid ventilation(PLV) using PFC(perfluorodecalin), compared with conventional gas ventilation in newborn piglets with saline lavage-induced respiratory distress. Methods : In a total of 16 instrumented and ventilated piglets, acute respiratory distress(below 70 mmHg of PaO2 at FiO2 1.0) was induced by repeated saline pulmonary lavage. The piglets were randomized...
Short-term Effects of Inhaled Corticosteroid Following Early Systemic Corticosteroid Administration in Premature Babies with Respiratory Distress Syndrome : A Preliminary Report
Hyeon-Soo Lee
J Korean Pediatr Soc. 2000;43(11):1440-1445.   Published online November 15, 2000
Purpose : To asses the short-term effects of the topical corticosteroid, budesonide administered by metered dose inhaler(MDI) and spacer(Aerochamber MV 15) following systemic corticosteroid in premature babies with respiratory distress syndrome at birth. Methods : 19 premature babies <1800gm were randomly assigned to receive steroids(n=9) or not (n=10). The steroid group(n=9, GA[gestational age]=29.6¡¾2.9 weeks, BW[birth weight]=1.29¡¾0.35kg) received systemic dexamethasone for 48...
Clinical Application of Impedance Audiometry in Children with Acute Otitis Media
Jee Sung Hwang, Sung Do Kim, Young-Ho Rah, Chong-Woo Bae
J Korean Pediatr Soc. 2000;43(11):1446-1450.   Published online November 15, 2000
Purpose : Acute otitis media is one of the most prevalent diseases of childhood and can cause serious complications such as hearing loss. The exact diagnosis is extremely important but may be hard to make because of probabilities of over- and underdiagnosis. We performed impedance audiometry(IA) in routine examinations for acute otitis media and applied it for screening and follow-up...
Follow up of Patients with Total Anomalous Pulmonary Venous Return in Right Atrial Isomerism
Soo Jin Kim, Jae Young Lee, Mi Young Han, Do Jun Jo, In Seung Park, Mee-Hye Oh, Eun Jung Bae, Seong Ho Kim
J Korean Pediatr Soc. 2000;43(11):1451-1457.   Published online November 15, 2000
Purpose : Total anomalous venous return(TAPVR) is associated in more than 60% of patients with right isomerism and can significantly complicate the management of single ventricle patients at any stage of management. We studied the results of management and sought to determine factors that may influence survival in patients with TAPVR in right atrial isomerism. Methods : Between February 1991 and...
Study of Congenital Mitral Stenosis Cases Requiring Surgical Correction in the First 2-Years of Life
In Seung Park, Young Seok Lee, Mi Young Han, Jae Young Lee, Soo Jin Kim, Do Jun Cho, Mee-Hye Oh, Woong-Han Kim, Young-Tak Lee, Eun Jung Bae, Seong Ho Kim
J Korean Pediatr Soc. 2000;43(11):1458-1464.   Published online November 15, 2000
Purpose : Congenital mitral stenosis(CMS) is a rare anomaly accounting for 0.4-0.5% of total heart disease. CMS which cases needed surgical correction in infancy are even rare. In this study, we analyzed 11 CMS patients of less than 2 year of age who needed surgical corrections, in order to find out their diagnoses, the characteristics, the results of operation and...
Congenital Chloride Diarrhea in 5 Korean Infants
Dong Hun Rhie, Sun Hwan Bae, Ji Eun Choi, Bo Young Yun, Dong Woo Son, Choong Ho Shin, Kyung Hee Park, Jae Sung Ko, Jeong Kee Seo
J Korean Pediatr Soc. 2000;43(11):1465-1472.   Published online November 15, 2000
Purpose : Congenital chloride diarrhea(CLD) is an autosomal recessive disease characterized by life-long watery diarrhea of prenatal onset with high fecal Cl- concentration. Recent studies have revealed that the protein product of the down-regulated in adenoma(DRA) gene is an intestinal anion transporter molecule and causes CLD when mutated. We investigated the clinical characteristics of CLD in Korean infants in order...
Clinical Features of Hemolytic Uremic Syndrome in Children
Ju Eun Lee, Su Yung Kim
J Korean Pediatr Soc. 2000;43(11):1473-1479.   Published online November 15, 2000
Purpose : Hemolytic uremic syndrome(HUS) is the most common cause of renal failure in childhood in western countries, but it has been a relatively rare disease in Korea. To analyze the clinical and epidemiologic characteristics of HUS in Korea, we reporte our experience. Methods : We reviewed retrospectively the medical records of 9 patients who were diagnosed the hemolytic uremic syndrome...
Serum Lipid Levels and Fatty Acid Metabolism in the Rat with Adriamycin Induced Cardiomyopathy
Young Mi Hong, Hye Ran Yoon
J Korean Pediatr Soc. 2000;43(11):1480-1487.   Published online November 15, 2000
Purpose : Adriamycin induced cardiomyopathy is irreversible and may procede to clinical congestive heart failure. Recently, it has been suggested that adriamycin may exert cardiomyopathy due to inhibition of transport across mitochondrial membranes mediated by the carnitine palmitoyltransferase system(CPT I). The effect of adriamycin on fatty acid metabolism according to cumulative dose was not clarified. The purpose of this study...
Intravenous Gamma-globulin Retreatment in Kawasaki Disease
Young Ah Lee, Hyun Kee Chung
J Korean Pediatr Soc. 2000;43(11):1488-1494.   Published online November 15, 2000
Purpose : This study was designed to determine the outcome and safety of intravenous gamma- globulin(IVGG) retreatment in Kawasaki disease. Methods : A clinical observation of the therapeutic effects, laboratory findings and echocardiograms was carried out on 72 patients with Kawasaki disease in Kosin University Hospital from 1991 to 1999. 27 patients were treated with 1g/kg/day IVGG for 2 days,...
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