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Volume 43(2); Feb 2000
Clinical Lecture
Therapeutic Effects of Growth Hormone Therapy in Short Children & Metabolic Disorders
Duk Hee Kim
J Korean Pediatr Soc. 2000;43(2):165-171.   Published online February 15, 2000
Original Articles
Adolescent Depression in a Provincial City
Ki Young Ryoo, Young Kyu Shin, Baik Lin Eun, Sang Hee Park, Young Chang Tocko
J Korean Pediatr Soc. 2000;43(2):172-178.   Published online February 15, 2000
Purpose : Most studies of depression in adolescents, have been conducted in western countries. Accordingly, we took a survey in the city of Ansan to discover the actual state of depression in adolescents and found a solution. Methods : Twelve questions of modified diagnostic criteria for DSM-Ⅳ(Diagonstic and Statistical Mannual of Mental Disorders, 4th ed.) major depressive disorder were filled out...
Construction and Application of Painting probe for Chromosome band 5q14-q15, 6q23, 16p11.2 and 22q12
Soo-Yeun Park, So Young Park, Joon-Il Kil, Yong-Hyuck Chun, Sun-Hwa Park
J Korean Pediatr Soc. 2000;43(2):179-187.   Published online February 15, 2000
Purpose : Chromosome microdissection has become a very powerful approach to generate chromosome band-specific library and painting probes for physical mapping or cytogenetic analysis. We have constructed here band-specific painting probes for human chromosomes by microdissection and polymerase chain reaction(PCR). Methods : We pretreated the microdissected fragments with Topoisomerase I(Topo I) which catalyzes the relaxation of supercoiled DNA, and performed...
Effects of Cisapride on QTc Interval and QT Dispersion in Preterm Infants
Heui Seung Jo, Chang Won Choi, Yun Kyung Lee, Hee Seok Kim, Jun Dong Park, Jun Huh, Beyong Il Kim, Chung Il Noh, Jung-Hwan Choi
J Korean Pediatr Soc. 2000;43(2):188-194.   Published online February 15, 2000
Purpose : Cisapride, a prokinetic agent, is widely used in preterm infants with feeding intolerance or gastroesophageal reflux. Although cisapride is regarded as a safe drug, increased QTc interval or ventricular arrhythmia has been reported in adults and neonates. So we prospectively examined the effects of cisapride on the QTc interval and QT dispersion in preterm infants. Methods : QTc interval...
A Clinical Study of Adenoviral Respiratory Infection in Children
Hong Keun Kim, Se Chang Ham, Seung Yeon Nam, Young Jae Koh, Kang Mo Ahn, Sang Il Lee
J Korean Pediatr Soc. 2000;43(2):195-202.   Published online February 15, 2000
Purpose : Adenoviral respiratory infection can develop a life threatening condition similar to severe bacterial pneumonia. Despite adequate intensive care, this infection progresses to acute respiratory distress syndrome and causes permanent lung damage in some patients. In this study, we analyzed clinical features and long-term follow-up clinical data of this infection in children. Methods : Forty-seven cases of inpatients were diagnosed...
Short-term Result of Radiofrequency Catheter Ablation in Pediatric Patients with Paroxysmal Tachycardia
Hee Suk Jang, Hee Jung Cho, Myung Chul Hyun, Sang Bum Lee, Young Keun Cho, Chang Ho Han
J Korean Pediatr Soc. 2000;43(2):203-209.   Published online February 15, 2000
Purpose : To find out the efficacy, safety and early complication of radiofrequency catheter ablation(RFCA) in pediatric patients with paroxysmal tachycardia, we compared short-term results of RFCA in pediatric patients to adult patients. Methods : We studied 25 patients(11 pediatric patients, 14 adult patients), who underwent RFCA due to paroxysmal supraventricular tachycardia(PSVT) or idiopathic ventricular tachycardia(VT) from November 1997 to August...
Treatment of Tachycardia by Radiofrequency Catheter Ablation in Children and Adolescents
Sung Jae Lee, Mi Jin Jung, Sung Ho Kim, Walter C. Schueller, Gil Hyun Kim, Hak Soo Lee
J Korean Pediatr Soc. 2000;43(2):210-215.   Published online February 15, 2000
Purpose : RFCA has been proven to be an effective and safe tool for treating different kinds of tachycardia in adults. This study was designed to analyze the efficacy of this method in children and adolescents. Methods : Seventy-eight patients referred to Gachon Medical School, Gil Hospital for ablation of supraventricular(SVT) and ventricular tachycardia(VT) between January 1997 and February 1999 were...
Lipid Profile Changes in Kawasaki Disease Patients
Ye-Jhin Lee, Young-Seok Lee, Myung-Chul Hyun, Sang-Bum Lee
J Korean Pediatr Soc. 2000;43(2):216-222.   Published online February 15, 2000
Purpose : Abnormality in the composition of lipid metabolism is well known to be a main cause of atherosclerosis. Accordingly the abnormality in lipid metabolism after suffering from Kawasaki disease may lead to premature coronary atherosclerosis. The aim of this study is to investigate the abnormalities of lipid metabolism in patients with Kawasaki disease. We studied 67 patients with Kawasaki...
A Clinical Study of Intravenous Gamma Globulin Re-treatment in Kawasaki Disease
Na Yeon Kim, Chun Hyuk Chang, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim
J Korean Pediatr Soc. 2000;43(2):223-228.   Published online February 15, 2000
Purpose : Intravenous gamma globulin(IVGG) treatment has reduced symptoms and complications in Kawasaki disease(KD). However, fever persisted in 20-30% of the patients, and there are no reliable data on the indication and dosage of IVGG re-treatment. Therefore, we tried to reveal the effectiveness of IVGG re-treatment and to find risk factors in predicting the re-treatment. Methods : Among 57 patients with...
Long-term Clinical Study of Total Anomalous Pulmonary Venous Return
Jin Young Song, Yong Soo Yoon
J Korean Pediatr Soc. 2000;43(2):229-235.   Published online February 15, 2000
Purpose : Total anomalous pulmonary venous return is a rare congenital heart disease, which is fatal if untreated, especially, if the obstruction in pulmonary venous return is obstructed. With the technical development of echocardiogram, we are now able to do an early diagnosis if TAPVR and perform surgery. Accordingly, this report was aimed to evaluate patients with TAPVR as well...
A Clinico-pathologic Study of Childhood Lupus Nephritis
Youn-Sook Rho, Sung-Hoo Cha, Byoung-Soo Cho
J Korean Pediatr Soc. 2000;43(2):236-240.   Published online February 15, 2000
Purpose : Systemic lupus erythematosus(SLE) is a disease of immunologic origin, affecting multiple organs including joints, skin, kidneys, nervous system, heart and blood, with rare involvement of gut and liver. The incidence of renal disease in children with SLE was approximately 70 percent and tended to be more severe than in adults. Accordingly we have retrospectively studied on the prognostic...
The Improvement of Cell Viability due to Dilution and Removal of DMSO in Thawing of Stem Cells
Hoon-Kyung Lee, Kyung-Ha Ryu, Il-Tae Whang, Eun Suk Kang, Ki Sook Hong, Kyung-Hyo Kim, Young-Mi Hong, Kyung-Hee Kim, Keun Lee
J Korean Pediatr Soc. 2000;43(2):241-246.   Published online February 15, 2000
Purpose : Cryopreserved stem cells from cord blood are usually infused with Dimethyl Sulfoxide (DMSO) immediately after thawing. However, this process may cause cell damage due to osmotic shock, and the administration of DMSO may also cause toxic effects. We studied a new method of increasing cell viability by stabilizing osmolarity by adding dextran 40 and washing out DMSO. Methods :...
Changes in Fat Tissue and Growth Hormone Receptor mRNA after Growth Hormone Therapy
Hye Jung Shin, Duk Hee Kim, So Chung Chung, Kyungyoon Kam
J Korean Pediatr Soc. 2000;43(2):247-252.   Published online February 15, 2000
Purpose : Growth hormone(GH) is a powerful inhibitor of lipoprotein lipase and is known to decrease fat cell mass. The lipolytic effect has more pronounced influence on visceral fat than subcutaneous fat. The effects of GH therapy on GH receptor in fat tissue are not clear. We investigated the changes in fat tissue and GH receptor mRNA in adipose tissue...
Medical Therapy in Children with Persistent Hyperinsulinemic Hypoglycemia of Infancy(PHHI)
Hyun-Jeong Kim, Mi-Jeong Kim, Hwa-Sook Shin, Jung-Sim Kim, Mie-Ryung Uhm, Si-Hwan Ko, Suk-Hyang Lee, Dong-Kyu Jin
J Korean Pediatr Soc. 2000;43(2):253-259.   Published online February 15, 2000
Purpose : Persistent hyperinsulinemic hypoglycemia of infancy(PHHI), which is characterised by inappropriate insulin secretion in spite of hypoglycemia, needs urgent treatment to prevent cerebral hypoglycemic damage. Although pancreatectomy is the treatment of choice for PHHI, there are several complications which follow treatment. We suggest that aggressive medical therapy, when effective, is preferable to partial pancreatectomy. Methods : We evaluated 8 patients...
Relation between Renal and Scrotal Involvement in Henoch-Schönlein Purpura
Eui Seong Lee, Pyung Kil Kim, Young Kwan Park, Hae Won Cheon, Kee Hwan Yoo
J Korean Pediatr Soc. 2000;43(2):260-266.   Published online February 15, 2000
Purpose : Although Henoch-Schönlein purpura(HSP) has been described in detail, there is a paucity of information describing scrotal involvement and risk factors for renal involvement. This study was performed to evaluate the incidence of scrotal involvement and the relationship between renal and nonrenal involvement, including scrotal involvement. Methods : We retrospectively reviewed medical records of 164 male children who were diagnosed...
Factors Related to the Outcome of Neonatal Seizures
Sung Koo Kim, Ran Lee, In Kyu Lee, Ki Joong Kim, Young Seung Hwang
J Korean Pediatr Soc. 2000;43(2):267-273.   Published online February 15, 2000
Purpose : Seizures during the neonatal period may be an important indicator of serious neurologic abnormalities and can cause permanent neurologic sequelae. We attempted to find and analyze the factors related to the outcome of neonatal seizures. Methods : Seventy-six newborns with seizure were reviewed. The outcomes were analyzed according to etiologic diseases, gestational ages, characteristics of seizure, and neuroimaging and...
Case Reports
A Case of Pallister-Killian Syndrome
Ju Suk Lee, Sung Hun Kim, Jung A Choi, Sang Yuk Nam, Su Young Kim
J Korean Pediatr Soc. 2000;43(2):274-277.   Published online February 15, 2000
Since Pallister first described 12p tetrasomy syndrome in 1977, approximately 50 patients have been described. Chromosomal study of lymphocyte is normal in most cases, but fibroblasts usually reveal 12p tetrasomy in chromosomal study. We report on a 17-month-old male infant with Pallister-Killian syndrome. He was admitted in our hospital for investigation of developmental delay and myoclonic seizure. He was diagnosed...
A Case of Megacystis Microcolon Intestinal Hypoperistalsis Syndrome
Jae Woo Lim, Jong Su Shin, Kyuchul Choeh, Chang Su Na, Tae Il Han
J Korean Pediatr Soc. 2000;43(2):278-282.   Published online February 15, 2000
Megacystis Microcolon Intestinal Hypoperistalsis(MMIH) Syndrome is a rare cause of functional neonatal bowel obstruction, characterized by hypoperistalsis, narrow distal ileum and colon, and bladder distension. We report a case of MMIH syndrome and review the literature. The patient was born after 34 weeks of gestation with marked abdominal distension. Her birth weight was 2,830g with 276ml of urine drained by...
A Case of Congenital Intrahepatic Portosystemic Venous Shunt
Do Yeon Kim, Dong Jin Lee, Jung Hyeok Kwon
J Korean Pediatr Soc. 2000;43(2):283-287.   Published online February 15, 2000
Intrahepatic portosystemic venous shunt(IPVS) is an uncommon pathologic condition which occurs mostly in adult patients with portal hypertension and cirrhosis of the liver with only scattered reports are on children. However, asymptomatic IPVS have been detected in an increasing number of patients with recent advances in imaging techniques, such as sonography, CT, MR imaging, and color Doppler sonography. The cause...
A Case of Hepatoblastoma with Precocious Puberty
Chang Won Choi, Hyun Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Sei Won Yang, Hyo Seop Ahn
J Korean Pediatr Soc. 2000;43(2):288-293.   Published online February 15, 2000
Hepatoblastoma is the most common primary malignant liver tumor in childhood. Most cases are boys generally below three years of age. Hepatoblastoma are associated with various non-metastatic syndromes. Rarely, human chorionic gonadotropin may be produced by the tumor. Ectopic gonadotropin production from this source is a rare cause of precocious puberty in boys. Since a report by Behrendt in 1931,...
A Case of Tuberous Sclerosis with Hydrocephalus and Multiple Cardiac Tumors in Neonatal Period
Young Jun Song, Won Seop Kim, Beom Soo Park, Heon Seok Han
J Korean Pediatr Soc. 2000;43(2):294-299.   Published online February 15, 2000
Several different tumors in different tissues(including the central nervous system, heart, kidney, liver, bone, and soft tissues) are found to be associated with tuberous sclerosis. In the brain, this tumor characteristically arises from the floor of the lateral ventricle and often occluded the foramen of Monro. Cardiac tumor is among the earliest signs of tuberous sclerosis and occurs in over...
A Case of Trichosporon beigelii Pneumonia in a Boy with Normal Immunological Status
Hyun Hee Kim, Hai Lee Chung, in Bok Hwang, Cheal Woo Ko
J Korean Pediatr Soc. 2000;43(2):300-305.   Published online February 15, 2000
Invasive diseases caused by Trichosporon beigelii are rare, usually fatal, opportunistic infections that occur exclusively in immunocompromised patients. This fungus has been known to produce cutaneous involvement in immunocompetent hosts, and is rarely reported to cause systemic disease in patients with cardiac valve replacement. In this report, we described a case of invasive Trichosporon beigelii pneumonia in a 9-year-old boy...
Two Cases of Bart`s Syndrome in Mother and Daughter
Si-Eun Lee, Yong-Suk Kim, Su-Jin Lee, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn, Jeong-Hee Lee
J Korean Pediatr Soc. 2000;43(2):306-311.   Published online February 15, 2000
We experienced two cases of congenital localized skin defect and neonatal onset of relapsing subepidermal blisters associated with minor trauma in a female newborn infant and her mother. The mother of index case showed toe nail dystrophy at delivery of her daughter, but the index case did not reveal nail dystrophy until 14 months of age. The congenital skin defects...
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