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Volume 43(3); Mar 2000
Childhood Cancer and Infection
Chin Moo Kang
J Korean Pediatr Soc. 2000;43(3):315-321.   Published online March 15, 2000
Clinical Lecture
Combination Vaccines
Chang Hwee Kim
J Korean Pediatr Soc. 2000;43(3):322-326.   Published online March 15, 2000
Original Articles
Anticancer Effect of Arsenic Trioxide in Acute Promyelocytic Leukemia
Ki Young Song, Jin Hye Park, Yoon Jung Cho, Won Ki Baek, Ki Young Kwon, Heung Sik Kim, Chin Moo Kang
J Korean Pediatr Soc. 2000;43(3):327-334.   Published online March 15, 2000
Purpose : Acute promyelocytic leukemia(APL or AML, M3) represents an unique model for cancer research in terms of biological and clinical features. Since 1988, it has been widely confirmed that all-trans retinoic acid(ATRA) can induce complete clinical remission in over 85% of APL patients by a differentiation process, with PML-RARα protein possibly being the direct target of ATRA. However, ATRA...
The Seoul Infant Developmental Screening Test
Keun Lee
J Korean Pediatr Soc. 2000;43(3):335-343.   Published online March 15, 2000
Purpose : The importance of early detection of developmental delays during infancy and preschool years has been repeatedly stressed, as early diagnosis of retardation increases the opportunities for effective therapy. Several screening tests developed in other countries are inappropriate for Korean children. The purpose of this study was to standardize a developmental screening method for Korean children. Methods : One hundred...
A Survey on the Adolescent Health Care in Pediatric Practice
Ki Hea Cho, Youn Jung Choi, Young Kyu Shin, Baek Lin Eun, Sang Hee Park, Chang-Ho Hong
J Korean Pediatr Soc. 2000;43(3):344-350.   Published online March 15, 2000
Purpose : This study was designed to establish standard guidelines to meet the growing health care needs of adolescents by direct assessment of pediatricians' current practices, attitude and obstacles to the primary care of adolescents. Methods : A questionnaire consisting of 9 questions, including personal characteristics of respondents, current health care practice of adolescents, attitude, obstacles to providing adolescent care, interest...
Immune Response to SA14-14-2 Live Attenuated Japanese Encephalitis Vaccine
Min Soo Park, Hye Ok Rho, Young Mo Sohn, Laura Chandler, Robert Shope, Theodore F. Tsai
J Korean Pediatr Soc. 2000;43(3):351-359.   Published online March 15, 2000
Purpose : SA14-14-2 live attenuated Japanese encephalitis(JE) vaccine has been administered safely and effectively to more than 100 million children in China since 1988, and recently licensure of the vaccine in Korea has been sought. Immune response to the vaccine was investigated. Methods : In the first clinical evaluation of the vaccine outside of China, we monitored side effects in 93...
The Usefulness of Fluorescence in Situ Hybridization(FISH) in the Diagnosis of Prader-Willi Syndrome
Young Ho Yang, Duk Hee Kim, So Chung Chung, Yong Seok Sohn, Mee Sun Kim
J Korean Pediatr Soc. 2000;43(3):360-364.   Published online March 15, 2000
Purpose : To detect microdeletion of 15q11-13 region, high resolution cytogenetic analysis or FISH with probe at Prader-Willi syndrome region can be used. We tried to evaluate whether FISH with SNRPN is a more effective method than G-banding microscope in the diagnosis of Prader-Willi syndrome. Methods : Peripheral blood sampling was done on five patients who we suspected of Prader-Willi syndrome...
Physiological Effects of Kangaroo Care(skin-to-skin care) in Small Preterm Infants and Their Parents
Heng-Mi Kim, Soo-Young Kim
J Korean Pediatr Soc. 2000;43(3):365-371.   Published online March 15, 2000
Purpose : Kangaroo care is the practice of holding a small premaure infant, naked except for a diaper and hat, against a parent's chest. The purpose of this study is to determine the safety and feasibility of kangaroo care in a NICU as defined by physiological variables. Methods : Ten stable, spontaneously breathing preterm infants, weighing less than 2,000gm were...
Apoptosis of Cord Blood Mononuclear Cells Infected with Enterovirus
Dong Soo Kim
J Korean Pediatr Soc. 2000;43(3):372-379.   Published online March 15, 2000
Purpose : To evaluate apoptosis of cord blood mononuclear cells(CBMC) infected with enterovirus. Methods : Cord blood was obtained from 20 neonates which were delivered vaginally without any complications. Cord blood mononuclear cells(CBMC) were isolated, and after 24h and 48h incubation, cells were stained with Annexin V and Propidium Iodide and were analyzed with FACScan flowcytometer. CBMCs were also incubated with...
A Study on the Clinical Significance of Periodic Lateralized Epileptiform Discharges and Relation to Brain Imaging Study in Children
Jong Hwa Lee, Eun Young Park, Nam Su Kim, In Joon Seol
J Korean Pediatr Soc. 2000;43(3):380-385.   Published online March 15, 2000
Purpose : Periodic lateralized epileptiform discharges(PLEDs), initially described by Chatrian et al in 1964, are an EEG phenomenon characterized by lateralized or focal spike-and-wave complexes with moderate to high voltage which occur in a periodic or semiperiodic pattern. This study was performed to assess the clinical significance of PLEDs and its relation to an imaging study of the brain. Methods :...
Effect of Hypoxia-ischemia on c-fos Expression in the Neonatal Rat Brain
Wang Bock Lee, Sun Hak Kwon, Heng Mi Kim
J Korean Pediatr Soc. 2000;43(3):386-394.   Published online March 15, 2000
Purpose : Brain damage resulting from a combination of hypoxia and ischemia in the newborn infant remains a major cause of perinatal death, cerebral palsy, mental retardation and epilepsy. Metabolic stress, including ischemia, hypoxia and seizures, induces the expression of a variety of stress proteins including nuclear proto-oncogene c-fos. The induction of c-fos can be considered a biomarker of events...
Study of Autoantibodies Against Platelet GP IIb/IIIa and GP Ib/IX in Childhood Chronic Idiopathic Thrombocytopenic Purpura
Chanwook Woo, Junghwa Lee, Kwangchul Lee, Soonkyum Kim
J Korean Pediatr Soc. 2000;43(3):395-401.   Published online March 15, 2000
Purpose : Chronic idiopathic thrombocytopenic purpura(CITP) is an autoimmune disease caused by autoantibodies reacting to certain antigens, and platelet glycoprotein(GP) IIb/IIIa and GP Ib/IX complexes are thought to be some of those antigens. However, the clinical significance of anti-GP autoantibodies in CITP patients is unknown. In this study, we investigated the clinical correlation between the presence of circulating autoantibodies against...
One Hundred Cases of HLA-matched Sibling Allogeneic bone Marrow Transplantation in Children : Single Center Study
Hack Ki Kim, Bin Cho, Nak Gyun Chung, Dae Chul Jeong, Soh Yeon Kim, Hyun Jung Lee, Kyong Su Lee, Kyung Ja Han, Won Il Kim, Il Bong Choi, Chun Choo Kim
J Korean Pediatr Soc. 2000;43(3):402-410.   Published online March 15, 2000
Purpose : We reviewed 100 cases of HLA-matched sibling allogeneic bone marrow transplantation( allo-BMT) in children and wish to share these results. Methods : One hundred children had undergone allo-BMT from HLA-identical siblings between Nov. 1983 and May 1998. There were 50 males and 50 females with a median age of 10 years and a median follow-up of 38 months. Out of 100 cases,...
Diagnostic Significance of the Urine-Stick Test in Middle and High School Children in Seoul
Mi Jung Park, Yun Ju Kang, Jong Hee Kim, Duk Hi Kim
J Korean Pediatr Soc. 2000;43(3):411-416.   Published online March 15, 2000
Purpose : This study was performed to assess the diagnostic significance of the urine-stick test in detecting Diabetes Mellitus(DM) and to assess the clinical characteristics of adolescent diabetes. Methods : A total of 926,208 middle and high school children participated. The urine-stick test was performed and those who showed glycosuria and, further studies such as evaluations of plasma glucose, triglyceride, cholesterol...
Case Reports
Five Cases of Prader-Willi or Angelman Syndrome Diagnosed by FISH in Neonate and Infancy
Hee Jung Chung, Young Rae Kim, Man Yong Han, Sook Hwan Lee
J Korean Pediatr Soc. 2000;43(3):417-422.   Published online March 15, 2000
The Prader-Willi syndrome(PWS) and Angelman syndrome(AS) are clinically distinct syndromes with a shared cytogenetic deletion of chromosome 15q11q13 in most patients. Currently the diagnosis of PWS/AS is clinically suspected and can be confirmed by genetic laboratory tests. However, their diagnosis remains difficult in neonates and early infants because many features of the syndromes change with age and the typical features...
Three Cases of Subacute Necrotizing Lymphadenitis in Childhood
Min Hyang Park, Jin A Son, Jae Wook Go, Jae Yoon Kim, Don Hee Ahn
J Korean Pediatr Soc. 2000;43(3):423-427.   Published online March 15, 2000
Subacute necrotizing lymphadenitis was first reported by Kikuchi and Fujimoto in 1972. Young females no more than 30 years of age are mainly affected. It usually manifests as fever and cervical lymphadenopathy. We experienced three cases of subacute necrotizing lymphadenitis in an 11-year-old boy, a 12- year-old boy and an 11-year-old girl. Symptoms presented were URI signs, diarrhea, headache and...
A Case of Factor Ⅶ Deficiency Presenting as Hemarthroses
Han Seong Ko, Kee Hwan Yoo, Kwang Chul Lee, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
J Korean Pediatr Soc. 2000;43(3):428-431.   Published online March 15, 2000
Factor Ⅶ deficiency has an estimated incidence of 1/500,000 in the general population and autosomal recessive pattern of inheritance. Factor Ⅶ deficiency is characterized by prolonged prothrombin time(PT), and normal activated partial thromboplastin time(aPTT) and bleeding time(BT). Definite diagnosis of this condition requires a specific Factor Ⅶ assay. The clinical features are variable and do not always correlate with the...
A Case of Bilateral Tubo-Ovarian Abscesses in a One-and-Half Year-Old Girl
Mun Hee Kim, Young Kyoo Shin, Baik Lin Eun, Sun Han Kim, Hai Joong Kim, Sang Hoon Cha, Young-Sik Kim
J Korean Pediatr Soc. 2000;43(3):432-437.   Published online March 15, 2000
Tubo-ovarian abscess is an end-stage disease of acute pelvic inflammatory disease(PID). Since most cases of PID are caused by sexually transmitted microorganisms, this is very rare in children. Here, we report an 1¨o-year-old girl with bilateral tubo-ovarian abscesses. She was admitted to our department with chief complaints of fever, vomiting and diarrhea. Abdominal ultrasonography and CT scanning of the patient...
A Case of Wolf-Hirschhorn Syndrome with Long Term Survival Diagnosed by Fluorescent In-situ Hybridization(FISH)
Eun Sil Dong, Mee Jeong Kim, Young Min Ahn, Myoung Sook Koo, Hwan Keuk Yong, Anna Lee
J Korean Pediatr Soc. 2000;43(3):438-443.   Published online March 15, 2000
Wolf-Hirschhorn syndrome is a multiple malformation syndrome associated with mental and developmental retardation, resulting from a deletion at the short arm of chromosome 4(4p16.3). We report a 11-year-old girl with Wolf-Hirschhorn syndrome, who was presented with severe growth and mental retardation along with characteristic features-frontal bossing, hypertelorism, downslanting of the palpebral fissures and fishlike lips. The diagnosis was confirmed by...
A Month-Old Infant with Chronic Granulomatous Disease Presented as Pulmonary Aspergillosis
SY Bae, JH Jung, KH Kim, YM Hong, HS Koo, JY Seoh, KS Hong, ES Kang, YS Won, JH Yoo
J Korean Pediatr Soc. 2000;43(3):444-449.   Published online March 15, 2000
Chronic granulomatous disease(CGD) is an uncommon inherited disorder in which phagocytic cells fails to produce antimicrobial superoxide(O2-) due to NADPH oxidase deficiency. This disease can be easily screened by PMA(phobol myristate acetate)-activated nitroblue tetrazolium(NBT) test. Also the disease has features of chronic pyogenic infection, granuloma formation, anemia, hypergammaglobulinemia, and leukocytosis. Treatment uses antibiotics sensitive to specific organism, surgical drainage...
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