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Volume 43(4); Apr 2000
Clinical Lecture
Careful Choice of Antimicrobial Agents in Primary Pediatric Care
Sung Hee Oh
J Korean Pediatr Soc. 2000;43(4):455-462.   Published online April 15, 2000
Original Articles
Apoptosis of Peripheral Blood Mononuclear Cells in Different Ages of Normal Children
Dong Soo Kim, Hyun Young Kim, John A Linton
J Korean Pediatr Soc. 2000;43(4):463-469.   Published online April 15, 2000
Purpose : To survive in an ecological environment, an individual must develop immunity to various antigens. Therefore, populations of peripheral blood mononuclear cells(PBMC) in humans change continuously with growth. The object of this study is to evaluate the apoptosis of peripheral blood mononuclear cells(PBMC) in normal children of different ages. Methods : PBMC were isolated from the study groups. Ten...
Comparison of Intraventricular Hemorrhagic Findings in Preterm Infants Between Brain Ultrasonogram and Magnetic Resonance Imaging at Discharge
Yong Kuk Kim, Sung Suk Do, Mi Hyun Cho, Sang Geel Lee
J Korean Pediatr Soc. 2000;43(4):470-476.   Published online April 15, 2000
Purpose : It has been customary to perform brain ultrasonogram(brain US) for the early detection of intraventricular hemorrhage(IVH) during intensive care of neonates. On the other hand magnetic resonance imaging(MRI) has been greatly restrictioned due to its complicated procedures. This study was conducted to identify changes in neonates' brain structure and to gain basic data for the long-term follow-up of...
Molecular Epidemiologic Analysis of a Cluster of Klebsiella Pneuminiae Infection in Neonatal Intensive Care Unit
Sung Soo Jin, Jong Hyun Kim, Jae Kyun Hur, Jin-Han Kang
J Korean Pediatr Soc. 2000;43(4):477-483.   Published online April 15, 2000
Purpose : Klebsiella pneumoniae is a major nosocomial pathogen in neonatal intensive care unit (NICU). Sequential outbreaks of K. pneumoniae infection in NICU could occur due to antibiotic resistant strains or persistent environmental sources in NICU. When these outbreaks are happen, epidemiological analysis must be performed to discover the nosocomial sources and clarify the nature of the outbreaks strains. We...
Oscillometric Blood Pressure of Upper and Lower Extremities and Aortic Blood Flow Velocity in Neonates
Sang Young Bae, Hae Soon Kim, Se Jung Sohn, Young Mi Hong
J Korean Pediatr Soc. 2000;43(4):484-488.   Published online April 15, 2000
Purpose : We studied the blood pressure difference between the upper and lower extremities in healthy newborn infants and the effect of isthmic narrowing of the aorta on making a possible difference. Methods : The blood pressure was measured with an oscillometric blood pressure device from four extremities of 62 healthy infants aged 1-15 days. A Doppler echocardiography was performed for...
Antibody Response and Adverse Reaction Following Immunization with MMR Vaccine Produced on Human Diploid Cells in Korean Children
Sung Hee Oh, Jin Han Kang, Young Mo Sohn, Hoan Jong Lee, Bok Yang Pyun, Chang Hwi Kim
J Korean Pediatr Soc. 2000;43(4):489-495.   Published online April 15, 2000
Purpose : This prospective study was performed to evaluate the immunogenecity and safety of MMR vaccine(Triviraten Berna¢c) in Korea children. Methods : Seventy-three infants aged between 12 to 18 months were recruited from several university hospitals between December 1995 to June 1996. MMR vaccine(Triviraten Berna¢c) was administrered and blood was obtained before and 6-10 weeks after vaccination. IgG antibodies against measles,...
The Clinical Significance of Cerebrospinal Fluid Interleukin-6 Levels in Viral Meningitis
Eun Joo Ju, In Chul Ahn, Jae Ho Lee
J Korean Pediatr Soc. 2000;43(4):496-501.   Published online April 15, 2000
Purpose : Cytokines found at a inflammatory site may be a good indicator of clinical severity of an infectious inflammatory disease. We assayed interleukin 6(IL-6) concentrations in cerebrospinal fluid(CSF) from patients affected with viral meningitis, and verified the relationship between IL-6 and inflammatory parameters and whether IL-6 can be used as a diagnostic marker in the diagnosis of viral meningitis. Methods...
Association between Tuberculin Responses and Serum IgE
Pil Ju Jeong, Yong Dae Ham, Jin Hwa Jeong, Jeong Ho Lee
J Korean Pediatr Soc. 2000;43(4):502-505.   Published online April 15, 2000
Purpose : Atopy is a state of allergic response, mediated by IgE, to common environmental allergens. In recent decades, there has been an increase in prevalence of atopic disorders in children in developed countries. The factor associated with the rise of atopy incidence may be declining exposure to some infection opportunities. The aim of this study is to determine if...
Etiologic Agents and Clinical Features of Acute Pyogenic Osteoarthritis in Children
Young Ho Kwak, Su Eun Park, Jung Youn Hong, He Sun Jung, Jin Young Park, Jung Hwan Choi, Hoan Jong Lee, In Ho Choi
J Korean Pediatr Soc. 2000;43(4):506-513.   Published online April 15, 2000
Purpose : Though acute pyogenic infections of musculoskeletal system are infrequent in children, delayed diagnosis or inadequate management may cause serious chronic sequelae. We analysed 40 cases of children who were affected by acute septic osteomyelitis and/or septic arthritis to find etiologic agents and to establish proper initial antimicrobial therapy. Methods : Medical records of 40 cases of microbiologically confirmed acute...
Factors Predictive of Response to Interferon-α Therapy in Children with Chronic Hepatitis B
Hong Kwon Kim, Bo Hwa Choi, Kyung Mo Kim, Kyung Hoon Kang, In Seok Lim, Eung Sang Choi
J Korean Pediatr Soc. 2000;43(4):514-519.   Published online April 15, 2000
Purpose : The efficacy and safety of interferon-alpha(IFN-α) therapy in children with chronic hepatitis B(CHB) is similar to that of adults. However, little information is available about the predictive factors of response to this therapy in children. The aim of this study was to determine the predictive factors for responsiveness to IFN-α therapy in children with CHB. Methods : The basal...
Congenital Heart Anomalies in Patients with Clefts of the Lip and/or Palate
Jin Ho Yu, Jeong Jin Yu, June Huh, Chung Il Noh, Jung Yun Choi, Yong Soo Yu
J Korean Pediatr Soc. 2000;43(4):520-525.   Published online April 15, 2000
Purpose : The prevalence of congenital heart anomalies is known to be higher in patients with clefts of the lip and/or palate(CL/P). The purpose of this study was to determine the prevalence and type of congenital heart anomalies in patients with CL/P. Methods : We investigated congenital heart anomalies in 756 patients presented with CL/P from January 1986 to December...
Infective Endocarditis in Children : Review of 35 Cases over 11 Years(1987-1997)
Jeong Jin Yu, Young Ho Kwak, Jung-Youn Hong, He Sun Jung, Jin Young Song, Hoan Jong Lee, Chung Il Noh, Jung Yun Choi, Yong Soo Yun
J Korean Pediatr Soc. 2000;43(4):526-534.   Published online April 15, 2000
Purpose : Infective endocarditis(IE) is a serious complication in children with structural heart disease. We reviewed 35 cases of IE to identify the recent changes in the pattern of preexisting heart diseases, the spectrum of causative organisms and prognosis. Methods : The clinical records of children diagnosed as IE at the Seoul National University Children`s Hospital from January 1987 through December...
Effect of Liver Transplantation in Children with Fulminant Hepatitis
Young Mee Seo, Bo Hwa Choi, Kyung Mo Kim, Kwang Min Park, Young Joo Lee, Sung Gyu Lee
J Korean Pediatr Soc. 2000;43(4):535-542.   Published online April 15, 2000
Purpose : Liver transplantation(LT) is regarded as an important management option for fulminant hepatitis(FH), which is associated with considerable mortality under conservative management. The aim of this study was to evaluate the outcome of children with FH according to management. Methods : We reviewed medical records of patients presented with FH from January 1994 until April 1999. The children were...
Changes in the Findings of 99mTc-dimercaptosuccinic Acid(DMSA) Scan after Acute Pyelonephritis in Childhood and Renal Scar
Sang Hee Ahn, So Young Yoon, Chong Hyun Yoon, Dae Hyuk Moon, Young Seo Park
J Korean Pediatr Soc. 2000;43(4):543-549.   Published online April 15, 2000
Purpose : We evaluated the change in the findings of DMSA scan after acute pyelonephritis (APN), and the relationship between renal scar formation and risk factors such as vesicoureteral reflux(VUR), organism and inflammatory reaction. Methods : We examined 200 patients under the age of 5 years with first APN. DMSA scan, voiding cystourethrography(VCUG), erythrocyte sedimentation rate(ESR) and C-reactive protein (CRP) were...
Serum Leptin Levels in Children with Type I Diabetes Mellitus
Eun Sil Lee, Han Ku Moon, Yong Hoon Park, Yong Woon Kim
J Korean Pediatr Soc. 2000;43(4):550-555.   Published online April 15, 2000
Purpose : Leptin is a highly hydrophobic 16-kDa protein encoded by the ob gene which is expre- ssed in adipocytes and participates in the regulation of food intake and energy expenditure. The aims of the present study were to examine the comparison of leptin levels between type I diabetes mellitus(DM) patients who received exogenous insulin therapy and healthy children, and...
Analysis of Risk Factors of Readmission to Hospital for Pediatric Asthma
Kyung Lim Yoon, Young Ho Rah, Chong-Woo Bae, Sa Jun Chung
J Korean Pediatr Soc. 2000;43(4):556-560.   Published online April 15, 2000
Purpose : The admission rates for pediatric asthma are increasing annually and are partially responsible for the increased rates of readmission. Selections of children with a high-risk of readmission and aggressive treatments of them may improve treatment outcome and cost- effectiveness. The purpose of this study is to evaluate the risk factors affecting readmission in cases of bronchial asthma in...
Case Reports
Two Cases of Pelizaeus-Merzbacher Disease
Ho Seok Kang, Se Wook Oh, Yong Won Park, Chong Guk Lee, Sang Woo Kim, Ghi Jai Lee
J Korean Pediatr Soc. 2000;43(4):561-566.   Published online April 15, 2000
Pelizaeus-Merzbacher disease(PMD) is a rare sudanophilic leukodystrophy with a reduced number of mature oligodendrocytes as well as diffuse central nervous system hypomyelination(dysmyelination) due to abnormal synthesis of proteolipid protein. PMD is characterized with pendular nystagmus, stridor, delay in psychomotor development, hypotonia, ataxia, athetosis and extrapyramidal signs. Abnormal high signal intensity is shown in the entire white matter of cerebrum and...
Four Cases of Congenital Depressed Skull Fractures in Neonates
Byung Soon Kang, Eun Young Kim, Chang Weon Oh, Kyoung Sim Kim, Yong Wook Kim, Min Suk Oh
J Korean Pediatr Soc. 2000;43(4):567-572.   Published online April 15, 2000
Depressed skull fractures in newborn babies mainly result from birth injury and rarely occurr in intrauterine life without any definable etiology. We present 4 cases of congenital intrauterine depressed skull fractures which were discovered at birth in neonates. Three babies(case 1, 2, 3) had round shallow depressions without adjacent soft tissue injury except the last one(case 4), showing sharp angulation...
A Case of Severe Hypertensive Pulmonary Edema Associated with Neuroblastoma during Chemotherapy
Hee Suk Cho, Hwang Min Kim, Seok Won Park, Jong Soo Kim, Yoon Mi Kim, Kwang Kil Lee
J Korean Pediatr Soc. 2000;43(4):573-577.   Published online April 15, 2000
The authors report a 7-year-old boy with neuroblastoma complicated by severe hypertension and pulmonary edema. Abdominal computed tomographic scan revealed a huge mass surrounding the aorta. After administration of cancer treatment, there was a marked increase in serum catecholamines level and hypertension, which resulted in pulmonary edema and heart failure. Alpha adrenergic blocking agents(prazocin, terazocin) were administrated, successfully controlling the...
A Case of Saldino-Noonan Type Short Rib-Polydactyly Syndrome
Hye Young Han, Gwang Hoon Lee, Eell Ryoo, Kang Ho Cho, Mi Jin Jung, Gil Hyun Kim, Hak Soo Lee, Hyuni Cho
J Korean Pediatr Soc. 2000;43(4):578-582.   Published online April 15, 2000
Short rib-polydactyly syndrome(SRPS) is a rare type of skeletal dysplasia characterized by short limb dysplasia, thoracic hypoplasia, polydactyly and multiple visceral anomalies. It is transmitted as a autosomal recessive trait. There have been 4 classic types of SRPS, of which Saldino-Noonan type is the most common, and is characterized by very narrow thorax, short limb, postaxial polydactyly, striking metaphyseal dysplasia...
A Case of Median Cleft Face Syndrome
Kyeong Hee Suh, Dae Chul Jeong, Jae Kyun Hur, Chang Kyu Oh
J Korean Pediatr Soc. 2000;43(4):583-587.   Published online April 15, 2000
Median cleft face syndrome is diagnosed by two or more of the following anomalies : ocular hypertelorism, cranium bifidum occultum, median cleft nose, median cleft lip and median cleft premaxilla. The most consistent and prominent ocular finding associated with this syndrome is hypertelorism. We experienced a case of median cleft face syndrome which had orbital hypertelorism, cranium bifidum occultum, bifid...
Acute Alcohol Intoxication in a Child
Mee Jeong Lee, Hyunmi Kim, Sang Gyu Park, Soo Youn Ham
J Korean Pediatr Soc. 2000;43(4):588-591.   Published online April 15, 2000
Information on ethyl alcohol intoxication in children is scarce. It is generally believed that children are more vulnerable to ethyl alcohol intoxication than adults. However, little information has been published on the effects of ethanol in the pediatric age group. The incidence of hypoglycemia and convulsions following ethanol intoxication is not known. We report a fatal case of acute alcohol...
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