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Volume 44(11); Nov 2001
Clinical Lecture
Immunotherapy for Rheumatoid Arthritis
Joong Gon Kim
J Korean Pediatr Soc. 2001;44(11):1215-1221.   Published online November 15, 2001
Original Articles
Classification and Risk Factors for Chronic Lung Disease(CLD) of Prematurity : Classical CLD Versus Atypical CLD
Chang Won Choi, Beyong Il Kim, Heui Seung Jo, Jun Dong Park, Chong Jae Kim, Bo Hyun Yoon, Jung-Hwan Choi
J Korean Pediatr Soc. 2001;44(11):1222-1232.   Published online November 15, 2001
Purpose : We tried to classify the different type of CLD and assess the risk factors for classical CLD and atypical CLD. Methods : Retrospective cohort analysis was done in 120 preterm infants with birth weights less than 1,500 g who were admitted to NICU in Seoul National University Children's Hospital between Jan. 1993 and Dec. 1998 and survived more...
The Role of Aldosterone on the Development of Renal Tubular Reabsorption in Low Birth Weight Infants
Byung Min Choi, Hoe Kyoung Koo, Jin Won Yook, Kyoung Bum Kim, Gi Young Jang, Moon Hee Kim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
J Korean Pediatr Soc. 2001;44(11):1233-1242.   Published online November 15, 2001
Purpose : To determine the postnatal changes in aldosterone action on the renal tubular reabsorption in low birth weight(LBW) infants, we assessed the relation of the aldosterone concentrations to renal parameters during the first 10 days of life. Methods : Twenty LBW infants were evaluated and their gestational ages ranged from 32.4 to 39.3 weeks and their birth weights ranged from...
Comparison of Brainstem Auditory Evoked Response in Normal Infants, Male and Female, Right and Left Ear
Soo Jin Han, Soo Shin Cho, Kang Ho Cho, EeIl Ryoo, Gwang Hoon Lee, Ho Joon Im, Kye Hwan Seol, Gil Hyun Kim, Hak Soo Lee
J Korean Pediatr Soc. 2001;44(11):1243-1248.   Published online November 15, 2001
Purpose : Brainstem auditory evoked response(BAER) is used as screening test for hearing disorders, damages of the central nervous system and congenital anomalies. We studied the difference values according to gender and stimulation sites in normal full-term infants. Methods : We performed BAER in 38 male and 28 female normal full-term infants, delivered in the Gil Medical Center, Gachen Medical School,...
Bystander Effect of HSV-TK/GCV Gene Therapy in Murine Neuroblastoma
Eun Jung Shim, Se Ryoung Kim, Eun Hae Park, Hyun Sang Cho, Jae Kook Cha, Hae Ran Lee
J Korean Pediatr Soc. 2001;44(11):1249-1253.   Published online November 15, 2001
Purpose : To demonstrate the bystander effect in murine neuroblastoma model which transduced with HSV-TK gene in vitro and in vivo. Methods : The LNC/TK vector was transfered in vitro into the neuro-2a cells, murine neuroblastoma cell line. Variable mixed populations of neuro-2a cells consisting of HSV-TK+ or HSV-TK- were plated into culture plates and treated with GCV for...
A Study on the Risk Factors of Periventricular Leukomalacia in Combined Use with Gentle Ventilation and High-Frequency Ventilation
Suk Ho Kang, Sung Eun Kim, Man Hoi Hur, Sang Geel Lee
J Korean Pediatr Soc. 2001;44(11):1254-1261.   Published online November 15, 2001
Purpose : It is suggested that persistent hypocarbia caused by ventilator therapy could be a risk factor in PVL. The study is aimed to discover whether for preventing hypocarbia with combined use of gentle ventilation and high frequency ventilation, other factors would be causers of PVL. Methods : Among 45 infants who were born and survived through ventilator treatment in...
The Effect of Tumor Necrosis Factor-α in Cultured Neonatal Rat Cardiomyocytes
Su Jin Kim, Dong Seok Lee, Ok Ko, Il Soo Mun, Bok Hyun Ko, Yong Wook Jung
J Korean Pediatr Soc. 2001;44(11):1262-1268.   Published online November 15, 2001
Purpose : Tumor necrosis factor-α(TNF-α) is a pro-inflammatory cytokine that has been implicated in the pathogenesis of cardiovascular disease. Serum levels of TNF-α are elevated in many human cardiac related pathogenic conditions, including heart failure. It is well known that TNF-α inhibits myocardial contractility and induces apoptosis of adult rat cardiomyocytes via stimulation of TNF receptor 1. But pathophysiologically relevant...
Factors Related to Weight Changes in Epileptic Children Treated with Vigabatrin
Sang-Nam Bae, Bong-Seok Choi, Sang-Ook Nam, Hee-Ju Park
J Korean Pediatr Soc. 2001;44(11):1269-1277.   Published online November 15, 2001
Purpose : This study was undertaken to investigate factors related to weight changes in children treated with vigabatrin(VGB). Methods : We have analyzed mean weight standard deviation scores(SDS) retrospectively and interviewed 35 childhood epileptic patients attending Pusan National University Hospital on VGB monotherapy followed over 36 months. Putative risk factors including sex, age, duration of VGB administration, mean weight SDS...
Effect of Resuscitation with High Concentration Oxygen on a Rat Model of Neonatal Hypoxic-Ischemic Brain Injury
Dong Seok Lee, Su-Hee Kwak, Heng-Mi Kim, Yoon Kyung Sohn
J Korean Pediatr Soc. 2001;44(11):1278-1288.   Published online November 15, 2001
Purpose : This study was undertaken to determine whether any features of apoptosis would occur in the established model of cerebral hypoxia-ischemia in neonatal rats. It was also undertaken to evaluate the effect of post-insult hyperoxia on hypoxic ischemic cerebral injury. Methods : Seven-day-old neonatal rats underwent unilateral carotid artery dissection followed by 2 hours of hypoxia. To this end...
A Clinical Study on Varicella zoster Virus Infection, Relating Factors and Treatment in Pediatric Cancer Patients
Yoon Sook Chung, Su Hyun Kim, Ki Joong Kim, Hahng Lee
J Korean Pediatr Soc. 2001;44(11):1289-1294.   Published online November 15, 2001
Purpose : We performed this study to contribute to the prevention and treatment of Varicella zoster virus infection in pediatric cancer patients through understanding of VZV infection, acyclovir efficacy and varicella vaccination. Methods : A retrospective study was performed by reviewing chart from January 1988 to January 2001. Results : The diseases among 19 cases were leukemia. 12 cases were solid...
Six Year Follow-up of Childhood Obesity
Eun Young Kim, Young Il Rho, Eun Seok Yang, Sang Kee Park, Yeung Bong Park, Kyung Rye Moon, Chul Gab Lee
J Korean Pediatr Soc. 2001;44(11):1295-1300.   Published online November 15, 2001
Purpose : To examine the prevalence of obesity in elementary school-aged children in Gwangju, and long term courses of those obese children. Methods : We examined children aged 7 to 12 in the total number of 3,028 elementary school students consisting of 1,579 boys and 1,449 girls between 1994 and 1999. Obesity was defined as weight that exceeded the standard weight...
Case Reports
A Case of the Use of Intravenous Immunoglobulin of Treatment for HyperIgE Syndrome
Yoon Ji Choi, Dong IL Lee, Hong Bae Kim
J Korean Pediatr Soc. 2001;44(11):1301-1304.   Published online November 15, 2001
Hyper-IgE syndrome is a rare congenital immune deficiency disease characterized by severe eczema, recurrent infection of the sinopulmonary tract, cold subcutaneous abscess and high serum IgE levels. It is an autosomal dominant disease with incomplete penetrance. We examined the case of a 12 month old infant with hyperIgE syndrome since neonate. The diagnosis of hyper IgE syndrome was made because...
A Case of Polio-like Encephalomyelitis Associated with Enterovirus 71 Infection
Hyun Kyung Roh, Hee Jung Chung, Young Mee Jee, Doo Sung Cheon
J Korean Pediatr Soc. 2001;44(11):1305-1310.   Published online November 15, 2001
Enterovirus 71(EV71), like polioviruses, invades the central nervous system to give rise to aseptic meningitis, encephalitis or myelitis. EV71 was first isolated in California in 1969 from a 9-month- old infant with encephalitis. Since then it has been isolated from the brain of children who died of encephalitis and from feces of patients with meningitis, encephalitis or paralysis. Related strains...
A Case of Hypoglossia-Hypodactylia with t(3q;19p)
Hei-Won Hwang, Ji-Sun Mok, Ji-Eun Kim, Dong-Suk Lee, Doo-Kwun Kim, Sung-Min Choi, Woo-Taek Kim
J Korean Pediatr Soc. 2001;44(11):1311-1315.   Published online November 15, 2001
Hypoglossia-hypodactylia syndrome is a congenital disease which is characterized by severe micrognathia, hypoglossia and various anomalies of extremities. This was first reported as 'aglossia congenita' back in 1932 by Rosenthal, and has been reported many times ever since, but has never been reported in Korea. Hall first used the term 'hypoglossia-hypodactylia syndrome', and classified it as one of the oromandibular-limb...
A Mesenteric Lymphangioma Causing Billous Vomiting and Bloody Stool in a 3-day-old Infant
Jeum-Su Kim, Hae-Seoung Jung, Ki Su Kang, Yong-Suk Kim, Chan-Hoo Park, Myoung Bum Choi, Hyang-Ok Woo, Gyung-Hyuck Ko, Hee-Shang Youn
J Korean Pediatr Soc. 2001;44(11):1316-1319.   Published online November 15, 2001
Mesenteric lymphangioma, which is rare and often diagnosed incidentally, is a benign tumor in infants and children. Most cases of lymphangioma are in the neck and axilla. About 5% of these lesions are in the mediastinum, mesentery or retroperitoneal region. Although most lymphangioma produce no symptoms, it may present an acute surgical condition suggesting acute intestinal obstruction. We report one...
A Case of Wernicke's Encephalopathy which Occurred During Chemotherapy in a Child with Acute Myeloblastic Leukemia
Sang-Nam Bae, Bu-Jin Kim, Seong-Shik Park, Sang-Ook Nam, Young-Tak Lim, Hak-Jin Kim
J Korean Pediatr Soc. 2001;44(11):1320-1325.   Published online November 15, 2001
Wernicke,s encephalopathy(WE), a neurological disorder caused by thiamine deficiency, is characterized by the triad of ocular symptoms, ataxia, and mental confusion. More than 90% of the cases are observed in chronic alcoholics. Other conditions less frequently associated with WE are anorexia nervosa, prolonged parenteral nutrition, hemodialysis, uremia, hyperemesis gravidarum, gastroplasty for morbid obesity, and acquired immunodeficiency syndrome(AIDS). One of the...
A Case of Disseminated Lymphangiomatosis Involving Mediastinum, Bone, Spleen and Retroperitoneum in an Asymptomatic Healthy Child
Kyung Hee Yoon, Seung Ju Ha, In Sook Park, Hyun Woo Goo, Jong Hyun Yoon
J Korean Pediatr Soc. 2001;44(11):1326-1329.   Published online November 15, 2001
Lymphangiomatosis, a benign tumor consisting of a cluster of dilated lymphatic channels, is very unusual. Most lymphangiomatoses are found in the neck and head area. Less than 5% are diagnosed intraabdominally and they are very infrequently encountered in the retroperitoneal area. Herein, we report a rare case of asymptomatic lymphangiomatosis of a 13 year-old boy during a routine chest...
A Case of Successful Danazol Therapy in Autoimmune Thrombocytopenia Associated with Systemic Lupus Erythematosus
Kyung Min Kim, Byeong Seon Lee, Young Seo Park
J Korean Pediatr Soc. 2001;44(11):1330-1333.   Published online November 15, 2001
Autoimmune thrombocytopenia and autoimmune hemolytic anemia occur in 10-26% of patients with systemic lupus erythematosus(SLE). These hematological manifestations may be the sole presenting sign and can precede the appearance of diagnosable SLE in 5 to 23% of cases. The conventional treatment for SLE associated with these disorders includes corticosteroid therapy and splenectomy, but autoimmune thrombocytopenia or autoimmune hemolytic anemia may...
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