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Volume 46(2); Feb 2003
Clinical Lecture
Neuromuscular Disorders in Childhood
Jong Hee Chae, Yong Seung Hwang
J Korean Pediatr Soc. 2003;46(2):109-115.   Published online February 15, 2003
Medical Lecture Course
The Evidence of Epileptic Seizure-induced Neuronal Injury by Animal Study
Byung Ho Cha
J Korean Pediatr Soc. 2003;46(2):116-121.   Published online February 15, 2003
Original Articles
A Study of the Effects and Risks of Baby-walkers on Motor Development in Human Infants
Ji Young Lee, Sae Ah Min, Sun Hee Yu, Young Taek Jang
J Korean Pediatr Soc. 2003;46(2):122-127.   Published online February 15, 2003
Purpose : Baby-walkers are used by many parents because of the convenience they provide in keeping children occupied, quiet, happy, and in stimulating ambulation. But, these devices have more risks than benefits. Therefore, we performed a study to evaluate the effects of baby-walkers on motor development of human infants according to the hours used in a day, total duration(months), and...
Characterization of B Cells of Lymph Nodes and Peripheral Blood in a Patient with Hyper IgM Syndrome
Dong Soo Kim, Kyuong Mi Shin, Woo Ick Yang, Jeon-Soo Shin, Chang Hwa Song, Eun Kyeong Jo
J Korean Pediatr Soc. 2003;46(2):128-136.   Published online February 15, 2003
Purpose : Hyper IgM syndrome(HIGM) is characterized by severe recurrent bacterial infections with decreased serum levels of IgG, IgA, and IgE but elevated IgM levels. Recently, it has been classified into three groups; HIGM1, HIGM2 and a rare form of HIGM. HIGM1 is a X-linked form of HIGM and has now been identified as a T-cell deficiency in which mutations...
Diagnostic Significance of Neonatal Electroencephalography
Byeong Eui Kim, Heung Dong Kim
J Korean Pediatr Soc. 2003;46(2):137-142.   Published online February 15, 2003
Purpose : This study was performed to determine the sensitivity of neonatal electroencephalography (EEG) in detecting underlying brain disease, to compare the sensitivity and specificity of EEG with those of brain ultrasonography and to determine the prognostic value of EEG for neonatal neurologic diseases. Methods : Eighty-seven newborn babies were subjected to a electroencephalographic examination for the evaluation of underlying...
Relationship between Gb3 Expression and Cytotoxicity of Shiga-like Toxin I
Suk-Hwan Lim, Gi-Young Kim, Hyung-Chun Kim, Young-Hee Kim, Yong-Hae Son, Yang-Hyo Oh, Yeong-Min Park
J Korean Pediatr Soc. 2003;46(2):143-153.   Published online February 15, 2003
Purpose : Infection with Shiga-like toxin (SLT)-producing Escherichia coli, an emerging human pathogen found particularly in young children under 5 years of age, causes a spectrum of illnesses with high morbidity and mortality, ranging from diarrhea to hemorrhagic colitis and hemolytic uremic syndrome. Host mediators play an important role in the pathogenesis of SLT-I toxicity. The experiments described here were...
Evaluation of Prognostic Factors in Corrected Transposition of the Great Arteries at Mid-term Follow-up
Young-Hwan Song, Hyok-Joo Kwon, Gi-Beom Kim, Soo-Jung Kang, Eun-Jung Bae, Chung-Il Noh, Yong-Soo Yun, Jeong-Ryul Lee, Yong-Jin Kim, Joon-Ryang Rho
J Korean Pediatr Soc. 2003;46(2):154-161.   Published online February 15, 2003
Purpose : The prognosis of patients with corrected transposition of the great arteries(C-TGA) is variably affected by associated intracardiac defects, systemic right ventricular function, tricuspid valve competence, and conduction disturbances. This study aims to evaluate the importance of those factors at mid-term follow-up. Methods : Medical records of 94 patients(males 58, females 36; mean age at last follow-up, 12? years; mean...
Laboratory Values in Patients with Kawasaki Disease after Intravenous Immunoglobulin : Comparison of Patients with Coronary Artery Lesions to those without Coronary Artery Lesions
Min-Young Park, Kyung-Yil Lee, Ji-Whan Han, Hyung-Shin Lee, Ja-Hyun Hong, Kyung-Tai Whang
J Korean Pediatr Soc. 2003;46(2):162-166.   Published online February 15, 2003
Purpose : We evaluated the effects of intravenous immunoglobulin(IVIG) on level of laboratory parameters examined serially according to the existence of coronary artery lesions in children with Kawasaki disease. Methods : Children with Kawasaki disease(n=63), treated with IVIG at a dose of 2.0 g/kg, were classified as a group with coronary artery lesions(CALs+ group, n=9) or a group without coronary...
Hypoxia Induced Expression of Vascular Endothelial Growth Factor in Rat Pulmonary Artery Smooth Muscle Cells
Un Seok Nho, Yeo Hyang Kim, Myung Chul Hyun, Sang Bum Lee
J Korean Pediatr Soc. 2003;46(2):167-172.   Published online February 15, 2003
5% CO2-95% air atmosphere. The smooth muscle cells were confirmed by immunostaining with smooth muscle myosin and α-smooth muscle actin antibodies. The VEGF gene expression in the hypoxic group was compared with the one in control the group as well as the one in the starved group by RT-PCR and Northern blot hybridization. Results : There was no statistically significant difference...
The Usefulness of Spot Urine Protein/Creatinine Ratio in Evaluating Proteinuria in Children and the Correlation between 24-hour Urinary Protein Amount and Spot Urine Protein/Creatinine Ratio
Seon Young Hong, Ji Young Kim, Woo Yeong Chung
J Korean Pediatr Soc. 2003;46(2):173-177.   Published online February 15, 2003
Purpose : Recently, different results about factors affecting accurate quantitation of 24-hr urinary protein(24UP) amount using spot urine protein/creatinine ratio(PCR) have been reported. The current study was designed to evaluate correlation between 24UP amounts and PCR in children, and the effect of 24UP amounts, age, sex, and glomerular filtration rate(GFR) on this correlation. Methods : Among 94 patients who visited the...
Influence of Prognostic Factors on Survival Rate of Medulloblastoma Patient with Chemotherapy
Kyung Mi Shin, Sung Yeon Choi, Sung Chul Won, Chang Hyun Yang, Chuhl Joo Lyu, Chang Ok Suh, Joong Uhn Choi, Byung Soo Kim
J Korean Pediatr Soc. 2003;46(2):178-182.   Published online February 15, 2003
Purpose : Brain tumors are the second most common tumor in childhood, and medulloblastomas comprise 15-25% of brain tumors. The well known prognostic factors are age at diagnosis, stage of disease, and extent of surgical excision. In this study, we analysed the prognostic factors in patients who received chemotherapy after excision. Methods : We reviewed the medical records of 61...
Analysis of Affecting Factors for Cortisol Level in Cord Blood
Hyun Jung Lim, Chang Hun Song, Eun Young Kim, Sang Kee Park
J Korean Pediatr Soc. 2003;46(2):183-187.   Published online February 15, 2003
Purpose : Long-term stress to the fetus causes alterations in adrenal steroidogenesis. The purpose of this study was to analyze the association of cord blood cortisol with stress during delivery. Methods : Cord blood samples were collected from 58 neonates at once to labor. Cortisol was measured by RIA method(DPC, USA). Cortisol level according to gestational age(<34, 34-37, >38 wks)...
Case Reports
Analysis of Affecting Factors for Cortisol Level in Cord Blood
Eun Jung Kim, Chang Yoo Lee, Yeon Gyun Oh, Hyang Suk Yun, Jong Duck Kim
J Korean Pediatr Soc. 2003;46(2):188-191.   Published online February 15, 2003
Tsutsugamushi fever is a serious febrile disease outwardly similar to malaria and various arboviral infections. The endemic area is Asia-Pacific. This disease are generally associated with disturbed habitats favoring large populations of vector larval trombiculid mites. Therapy with tetracycline, chloramphenicol or ciprofloxacin is currently recommanded. Unfortunately these drugs is suboptimal for children and pregnant women. Recently, azithromycin has been proven...
A Case of Neonatal Tetanus Cured with Neuromuscular Blocking Agent and Ventilatory Support
Hyeon Joo Lee, Ji Young Jeong, Sa Jun Jung, Yong Mook Choi, Chong Woo Bae
J Korean Pediatr Soc. 2003;46(2):192-194.   Published online February 15, 2003
A neonate born at 38 gestational weeks was admitted due to generalized tonic-clonic seizure and cyanosis. The neonate was born six days previously at home through normal delivery and the umbilical cord was cut using scissors sterilized in boiling water. The neonate weighed 3,180 g at admission. Physical examination revealed cyanosis, opisthotonus, trismus and reactive muscle spasms. Laboratory exam, brain...
Familial Sick Sinus Syndrome
In-Hye Nam, Sung-Hee Cheon, Hong-Ryang Kil
J Korean Pediatr Soc. 2003;46(2):195-197.   Published online February 15, 2003
Sick sinus syndrome(SSS) constitutes a spectrum of cardiac arrhythmia, including sinus bradycardia, sinus pause-arrest, sinoatrial block, slow escape rhythm, bradyarrhythmia and tachyarrhythmia. SSS is relatively uncommon in children but its exact incidence is unknown because diagnostic criteria are not uniform and most children with SSS, in general are asymptomatic. SSS may be primary(organic sinus node disease) or secondary(cardiac surgery comprises...
Two Cases of Inhalation Injury Caused by An Explosion of Two Different Chemical Disinfectants(Sodium Dichloroiso Cyanurate & Calcium Hypochlorite) in a Swimming Pool
Su Jin Lee, Eun Young Park, Mi Ran Kim, Kon Hee Lee, Kwang Nam Kim
J Korean Pediatr Soc. 2003;46(2):198-202.   Published online February 15, 2003
Of all toxic inhalant exposures, chlorine is one of the most common toxic chemical inhalants. When acutely inhaled, it can be responsible for symptoms ranging from upper air way irritation to more serious respiratory effects. It can also deteriorate lung function and lead to death. Chlorine and its compounds such as chlorinated cyanurates and hypochlorites are commonly used in water...
Two Cases of Castlema's Disease in Childern
Eun Ah Kim, Chong Guk Lee, Han Sung Kim
J Korean Pediatr Soc. 2003;46(2):203-206.   Published online February 15, 2003
Castleman's disease is an atypical lymphoproliferative disorder of unknown origin. It has three histologic variants(hyaline vascular, plasma-cell, and mixed) and two clinical types(localized and multicentric). Some sufferers have constitutionalg symptoms and laboratory abnormalities such as anemia, hypoalbuminemia, hypergammaglobulinemia, and elevated erythrocyte sedimentation rate. The localized form is cured by complete surgical excision whereas the multicentric form is managed by prednisone...
A Case of Kawasaki Disease Associated with Acute Renal Failure and Necrotizing Myositis
So Hyun Ahn, So Yun Shim, Sejung Sohn, Seung Joo Lee, Un Seop Han
J Korean Pediatr Soc. 2003;46(2):207-209.   Published online February 15, 2003
Kawasaki disease is an acute febrile vasculitis affecting primarily infants and young children. In addition to the cardiovascular involvement, it may cause inflammatory changes in various organs and body systems : digestive, respiratory, urinary, nervous and musculoskeletal. A case is reported of atypical Kawasaki disease associated with acute renal failure and necrotizing myositis in the right gastrocnemius in a 10-year-old...
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