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Volume 46(6); Jun 2003
Clinical Lectures
Parenteral Nutrition
Kyung Rye Moon
J Korean Pediatr Soc. 2003;46(6):517-522.   Published online June 15, 2003
Diagnosis and Treatment of Head Louse Infestation
Ki-Soo Pai
J Korean Pediatr Soc. 2003;46(6):523-527.   Published online June 15, 2003
Medical Lecture Course
The Role of Basophils in the Mechanism of Allergic Inflammation
Hyun Hee Kim
J Korean Pediatr Soc. 2003;46(6):528-535.   Published online June 15, 2003
Original Articles
Immunocytochemical Study for Lactalbumin in Alveolar Macrophage of Human Milk Aspirated Mouse
Byoung Kil Han, Young Hun Chung
J Korean Pediatr Soc. 2003;46(6):536-540.   Published online June 15, 2003
Purpose : Aspiration of foreign material into the lungs can cause acute or chronic pulmonary diseases. It is difficult to detect small amounts of aspiration due to the lack of safe, sensitive and specific diagnostic tests. Recently, in animal or human studies, it has been reported that immunochemistry for lactalbumin can be used to detect the minimal aspiration. So, the...
Novel Gap Junction Molecules, Connexin 37, Enhances the Bystander Effect in HSVtk/GCV Gene Therapy
Sun Young Kim, Ho Keun Yi, Jung Chang Lee, Dong Jin Hwang, Pyoung Han Hwang, Dae Yeol Lee, Soo Chul Cho
J Korean Pediatr Soc. 2003;46(6):541-547.   Published online June 15, 2003
Purpose : Gap junction intercellular communication(GJIC) is an important mechanism of the bystander effect in herpes simplex thymidine kinase/ganciclovir(HSVtk/GCV) gene therapy Therefore, we attempted to enhance the bystander effect in vitro by exogenous overexpressing connexin 37(Cx37) in cells to increase GJIC. Methods : NIH3T3 cells were transfected with the Cx37 and HSVtk gene or the HSVtk gene alone by the calcium...
Increased Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Levels in the Cerebrospinal Fluid from Children with Aseptic Meningitis
Ju Hee Yang, Min Hyuk Park, Jung-Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuck Keum
J Korean Pediatr Soc. 2003;46(6):548-553.   Published online June 15, 2003
Purpose : Matrix metalloproteinase(MMP)-9 is known to breakdown the blood-brain barrier by degrading the extracellular matrix of the subendothelial basement membrane in meningitis. Tissue inhibitor of metalloproteinase(TIMP)-1, a known inhibitor of MMP-9, has been postulated to inhibit the proteolytic activity of MMP-9 by bindng to MMP-9, but their interaction has not been fully understood yet. So far, there have been...
Experimental Study for the Teratogenic Effect of Gamma-ray on the Heart of Chick Embryo
Yong Whan Jo, Nam Su Kim, Sung Yup Moon, Myeng Gul Yum, Sung Hoon Kim, Ha Chung Chun, Yong Joo Kim, Hahng Lee
J Korean Pediatr Soc. 2003;46(6):554-560.   Published online June 15, 2003
Purpose : To investigate the teratogenic effect of gamma-ray on the heart of chick embryo. Methods : 50 rad, 100 rad, 150 rad, 200 rad, 250 rad, and 300 rad of gamma-ray were used to irradiate three days old chick embryos. The control group was not irradiated. After three weeks, the embryos were sacrificed and examined for cardiovascular malformation. Results :...
Recurrence and Follow-up after Urinary Tract Infection
Ji Hee Kim, Hye Kyung Shin, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
J Korean Pediatr Soc. 2003;46(6):561-565.   Published online June 15, 2003
Purpose : Urinary tract infection(UTI) is the most common bacterial infectious disease that may induce severe renal injury unless early diagnosis and appropriate treatment are performed. If recurrent UTI is prevented, renal injury can be also reduced. Therefore, we studied the risk factors of recurrent UTI in children. Methods : We performed a retrospective study of 168 children(58 girls and 110...
Leukoencephalopathy after CNS Prophylactic Therapy in Pediatric Hematologic Malignancy
Jun Hwa Lee, Sun Min Lee, Eun Jin Choi, Kun Soo Lee
J Korean Pediatr Soc. 2003;46(6):566-571.   Published online June 15, 2003
Purpose : Leukoencephalopathy(LE) is one of the most serious complications in children with hematologic malignancies during the course of treatment. Early recognition is important to reduce the impact and sequelae from LE. We therefore investigated the clinical features of LE following central nervous system(CNS) prophylaxis in children with hematologic malignancies and evaluated the significance of regular check-ups of brain MRI. Methods...
Endoscopic Findings of Children with Henoch-Schonlein Purpura
Dong Hoon Lee, Chul Han Park, Ji Min Park, Geun Soo Park, Heung Sik Kim, Chin Moo Kang
J Korean Pediatr Soc. 2003;46(6):572-575.   Published online June 15, 2003
Purpose : This study was performed to analyze the endoscopic findings in Henoch-Schonlein purpura patients, and to compare the differences in endoscopic findings according to age and gastrointestinal symptoms. Methods : We examined children with Henoch-Schonlein purpura aged 3 to 15 years between September 1996 and October 2002. The total number studied was 65, consisting of 41 boys and 24...
Henoch-Scholein Purpura Presenting with Acute Abdominal Pain Preceding Skin Rash : Review of 23 Cases
Ju Young Chang, Yong Joo Kim, Kyo Sun Kim, Hee-Ju Kim, Jeong Kee Seo
J Korean Pediatr Soc. 2003;46(6):576-584.   Published online June 15, 2003
Purpose : For the early diagnosis of Henoch-Schonlein purpura(HSP) presenting with acute abdominal pain preceding skin rash. Methods : The clinical, endoscopic and radiological records of 23 cases of HSP, presenting with gastrointestinal symptoms preceding skin rash were reviewed. Results : The intervals from the onset of abdominal pain to the development of the skin rash were one day to 30 days(median...
Autonomic Neuropathy in Adolescents with Diabetes Mellitus
Eun-Gyong Yoo, Sun-Young Ahn, Duk Hee Kim
J Korean Pediatr Soc. 2003;46(6):585-590.   Published online June 15, 2003
Purpose : This study is designed to determine the prevalence of cardiovascular autonomic neuropathy and its relationship to risk factors in adolescents with diabetes mellitus(DM). Methods : Ninety-two diabetic patients(80 with type 1 DM and 12 with type 2 DM), ranging from eight to 26 years of age, were studied for cardiovascular autonomic function, and the relationship to age, duration...
Clinical Characteristics of Kawasaki Disease in Infants Younger than 3 Months of Age
Soo Jeong Lee, So Jung Kim, Hae Soon Kim, Sejung Sohn
J Korean Pediatr Soc. 2003;46(6):591-596.   Published online June 15, 2003
Purpose : Kawasaki disease(KD) is rare in infants <3 months of age. In this younger group, the diagnosis may be delayed due to lack of most of the clinical criteria, resulting in a high risk of cardiac complications. We examined clinical characteristics in these patients for early recognition and treatment. Methods : We conducted a retrospective study on the infants...
Case Reports
A Case of Trisomy 9 Mosaicism
Young Ok Kim, Chun Hak Park, Ic Sun Choi, Hyun Jung Kim, Chang Yee Cho, Young Youn Choi
J Korean Pediatr Soc. 2003;46(6):597-601.   Published online June 15, 2003
Trisomy 9 mosaic syndrome is a rarely reported chromosomal abnormality with high incidence of intrauterine growth retardation and perinatal death. Even a baby lives, he has severe mental retardation and significant malformations. The incidence and severity of malformations and mental retardation correlate with the percentage of trisomic cells in the different tissues. The characteristic craniofacial abnormalitis are narrow bifrontal diameter,...
A Case of Scrotal Abscess Associated with Gastroenteritis and Sepsis due to Salmonella Group D in a One Month Old Infant
You Sun Choi, Yoon Suk Jung, Sun Il Kim, Sung Hee Oh
J Korean Pediatr Soc. 2003;46(6):602-605.   Published online June 15, 2003
Acute gastroenteritis due to Salmonella species, which usually improves on conservative treatment, can progress to sepsis and extraintestinal focal infection in very young infants. Frequent sites for extraintestinal infections are meninges, bone, joints, spleen and intravascular sites but scrotal abscess due to salmonella in children has been very rare. Literature search revealed only one newborn case of scrotal abscess with...
A Case of Goltz Syndrome
Dong Hoon Lee, Chul Han Park, Ji Min Park, Set Byul Park, Heung Sik Kim, Young Wook Ryoo, Kyu Suk Lee, Hee Jung Lee
J Korean Pediatr Soc. 2003;46(6):606-609.   Published online June 15, 2003
Goltz syndrome(focal dermal hypoplasia) is a rare disorder characterized by ectodermal and mesodermal dysplasia described in 1962 by Goltz. In Korea, one case of Goltz syndrome was reported in 1994. The inheritance mode is mostly X-linked dominant. Skin abnormality is the most common manifestation including hypoplasia of the dermis. Skeletal involvement such as syndactyly, polydactyly, scoliosis, kyphosis and spina bifida...
Stenosis of Individual Pulmonary Veins
Mira Lee, Kil Soon Choi, Nam Su Kim, Myung Kul Yum, Yong Joo Kim, In Jun Sul
J Korean Pediatr Soc. 2003;46(6):610-614.   Published online June 15, 2003
Pulmonary hypertension may be associated with variable conditions such as the hyperkinetic state or pulmonary vascular obstruction. In these, stenosis of the individual pulmonary veins without any cardiac or vascular malformation is very rare. We experienced stenosis of individual pulmonary veins in a 10 months old boy who was admitted with recurrent dyspnea and cyanosis and then underwent angiogram and...
A Case of Cystinosis
Min Ho Jung, Seung On Keun, Soon Ju Lee, Byung Churl Lee
J Korean Pediatr Soc. 2003;46(6):615-619.   Published online June 15, 2003
Cystinosis, an autosomal recessively inherited lysosomal storage disease, results from impaired transport of the amino acid cystine out of cellular lysosomes. The consequent accumulation and crystallization of cystine destroys tissues, causing growth retardation, Fanconi syndrome, renal failure, eye problems, and endocrinopathies. The gene for cystinosis, CTNS, was mapped to chromosome 17p13. The diagnosis of cystinosis was made by measuring the...
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