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Volume 49(10); Oct 2006
Review Articles
Motor delay : cerebral palsy
Ho Jin Park
Korean J Pediatr. 2006;49(10):1019-1025.   Published online October 15, 2006
Motor delay, when present, is usually the first concern brought by the parents of children with developmental delay. Cerebral palsy that is the most common motor delay, is a nonspecific, descriptive term pertaining to disordered motor function that is evident in early infancy and is characterized by changes in muscle tone, muscle weakness, involuntary movements, ataxia, or a combination of...
Mental retardation and other neurodevelopmental disorders
Kwon Soon Hak
Korean J Pediatr. 2006;49(10):1026-1030.   Published online October 15, 2006
Mental retardation(MR) is one of the most common developmental disabilities, which is characterized by deficits in intellectual and adaptive functions. Most children with MR have cognitive limitation in the mild range. With respect to the etiology, it is believed that genetic and environmental factors are interrelated and show variable pictures. Most children with MR present with speech and language delay...
Concept of developmental disability and the role of a pediatrician
Young Jong Woo
Korean J Pediatr. 2006;49(10):1031-1036.   Published online October 15, 2006
In this article, the following topics will be discussed: What is a developmental disability? What are the risk factors for developmental disability? What are the causes of delayed motor development? What are the early manifestations of developmental disability in young infants? What are the goals of early intervention and the forms or types of early intervention services? What are the...
Original Articles
Adolescent obesity and the elevation of aminotransferase levels
Su Yeon Kim, Ho Jun Lee, Tae Su Park, Soo Geun Kim, Hye Jung Shin
Korean J Pediatr. 2006;49(10):1037-1041.   Published online October 15, 2006
Purpose : The prevalence of obesity and nonalcoholic steatohepatitis(NASH) was increased in adolescents. This study was performed to observe the prevalence of elevated aminotransferase levels in adolescents and to assess the correlations between aminotransferase levels and obesity related parameters(body mass index, waist circumference, hip circumference, waist to hip ratio and insulin level). Methods : We obtained weight, height, waist circumference and...
Health and risk taking behaviors of freshmen in college
Hong Ki Ko, Jae Joon Han, Yoon Lee, Young Yoo, Kee Hyoung Lee, Ji Tae Choung, Sang Hee Park
Korean J Pediatr. 2006;49(10):1042-1049.   Published online October 15, 2006
Purpose : This study was conducted to survey the preliminary data on risk behaviors and to identify the factors that prevent risk-behaviors in late adolescence. Methods : Freshmen(n=1,297) beginning the first semester in Korea University, Seoul, Korea completed self-administered risk behavior questionnaires, comprising 5 domains : demographics, smoking, drinking, drug abuse and sexual behavior. Results : The rate of smoking experience was...
Changes of neurodevelopmental outcomes and risk factors of very low birth weight infants below 1,500 g, in the last 10 years
Se Kyu Lee, Ji Hyun Lee, Sang Geel Lee
Korean J Pediatr. 2006;49(10):1050-1055.   Published online October 15, 2006
Purpose : As a result of advances in neonatal intensive care and perinatal care, neurodevelopmental outcomes of very low birth weight infant(VLBWIS) is expected to lead to improvement. The aim of this study was to report neurodevelopmental outcomes and risk factors of neurologic impairment of very low birth weight infants during the past 10 years. Method : We performed a retrospective...
Analysis of newborn hearing screening using automated auditory brainstem response
Sung Won Park, Byung Ho Yun, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin, Sung Hwa Hong
Korean J Pediatr. 2006;49(10):1056-1060.   Published online October 15, 2006
Purpose : As hearing ability affects language and cognitive development, early detection and intervention of congenital hearing defects is very important. We analyzed the result of newborn hearing screening using automated auditory brainstem response and estimated the incidence of congenital hearing defects in newborn infants in Korea. Methods : Hearing screening tests were done on 7,218 newborn infants who were...
Analysis of cow's milk specific IgE positive patients in newborns
Gil Sang Lee, Nam Kyung Baek, Won Duck Kim
Korean J Pediatr. 2006;49(10):1061-1066.   Published online October 15, 2006
Purpose : The purpose of this study was to research whether measurement of cow's milk specific IgE on the newborn would be helpful in the diagnosis of cow's milk allergy. We tried to find out the relation between cow's milk specific IgE and other allergy diseases by following up cases. Methods : We reviewed clinical features of 87 episodes in infants...
A case of hereditary pancreatitis with a N29I mutation in the cationic trypsinogen gene
Jee Youn Shin, You Jeong Kim, Jeong Kee Seo
Korean J Pediatr. 2006;49(10):1067-1072.   Published online October 15, 2006
Purpose : The purpose of this study was to examine the clinical courses and long-term outcomes of children with Allagille syndrome in Korea, and to evaluate the prognostic potentials of identified variables. Methods : We reviewed the clinical manifestations and outcomes of 30 children with Alagille syndrome, investigated from 1984 to 2006 until the end of this study (defined as death...
Impact of fetal diagnosis of congenital heart disease on parents
Eun Young Choi, Chang Hoon Lee, Myung Ja Yoon, Eun Sook Han, Joon Suk Hong, Yun Sook Jung, Jung Yun Choi
Korean J Pediatr. 2006;49(10):1073-1078.   Published online October 15, 2006
Purpose : This study was performed to assess how a fetal diagnosis of congenital heart disease affects parents, as regards pregnancy management and care of infants after birth. Methods : Database search to find out abnormal fetal echocardiography performed at Seoul National University Children's Hospital from July 1988 to June 2003 revealed 370 examinations. After excluding both arrhythmias without structural cardiac...
Factors affecting hematologic recovery and infection in high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk solid tumor
Jung Hyun Lee, Bo Lyun Lee, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hye Lim Jung, Eun Joo Cho, Hong Hoe Koo
Korean J Pediatr. 2006;49(10):1079-1085.   Published online October 15, 2006
Purpose : The purpose of this study was to evaluate factors affecting hematologic recovery and infection in high-dose chemotherapy(HDCT) and autologous stem cell transplantation(ASCT) in patients with high-risk solid tumor. Methods : From January 2004 to December 2005, 72 HDCTs and ASCTs were applied to children with high-risk solid tumor at Samsung Medical Center. Medical records of these 72 HDCTs and...
Clinical significance of cerebrospinal fluid pleocytosis in pediatric refractory status epilepticus
Jung Mi Kim, Young Mi Kim, Soon Hak Kwon
Korean J Pediatr. 2006;49(10):1086-1092.   Published online October 15, 2006
Purpose : Refractory status epilepticus(RSE) is a serious neurological emergency in children. The mortality is high and the neurological outcome is not good. This study aimed to evaluate the clinical significance of cerebrospinal fluid(CSF) pleocytosis in refractory status epilepticus in children. Methods : From January 1999 to January 2006, 25 out of 37 children with refractory status epilepticus had...
Serum homocysteine and tumor necrosis factor-alpha levels after intravenous gammaglobulin treatment in patients with Kawasaki disease
Jung Hwa Cha, Young Mi Hong
Korean J Pediatr. 2006;49(10):1093-1099.   Published online October 15, 2006
Purpose : Homocysteine is a strong and independent risk factor for cardiovascular disease. The deleterious effects of homocysteine included endothelial dysfunction, arterial intimal-medial thickening, wall stiffness and procoagulant activity. However, the precise mechanism responsible for homocysteine release in children with coronary artery disease is still unknown. The purpose of this study was to investigate serum homocysteine and tumor necrosis factor(TNF)-α...
NELL2 gene as regulator of cell cycle in neuron differentiation
Mi Rim Joung, Yeon Mi Oh, Woo Saeng Park, Sang Kyu Park
Korean J Pediatr. 2006;49(10):1100-1105.   Published online October 15, 2006
Purpose : Because NELL2 expression is strictly restricted only in neurons in developing and post- differentiated neural tissues, it is thought to be involved in the neuronal differentiation during development and in the maintenance of neuronal physiology in the post-differentiated neurons. In this study, we examined whether NELL2 is involved in the regulation of cell cycle and apoptosis in the...
Case Reports
A case of post-operative chylous ascites after a splenorenal shunt operation in a child with congenital hepatic fibrosis
Jong Hyung Yoon, Hye Ran Yang, Jae Sung Ko, Jeong Kee Seo
Korean J Pediatr. 2006;49(10):1106-1110.   Published online October 15, 2006
Chylous ascites is a rare condition caused by various diseases and conditions that interfere with the abdominal or retroperitoneal lymphatics, and uncommonly it can manifest as a post-operative complication after abdominal, retroperitoneal or mediastinal surgery. Chylous ascites can be diagnosed by a high triglyceride content in ascites. The authors experienced a 5-year-old girl with congenital hepatic fibrosis who presented with...
A case of hereditary pancreatitis with a N29I mutation in the cationic trypsinogen gene
Jee Youn Shin, Dae Sung Oh, Jeong Min Rheu, Jeong Ok Shim, Ji Sook Park, Jae Sung Ko, Jeong Kee Seo
Korean J Pediatr. 2006;49(10):1111-1115.   Published online October 15, 2006
Hereditary pancreatitis is an autosomal dominant disease characterized by recurrent episodes of pancreatitis, often beginning in childhood, with a positive family history involving at least two other affected family members with no known other precipitating factors. Most forms of hereditary pancreatitis are caused by one of two common mutations, i.e., R122H in exon 3 and N29I in exon 2 of...
A case of pyomyositis due to Mycobacterium tuberculosis
Yun-Jin Bae, Jin-Sung Choi, Young Ah Lee, Sung-Soo Kim, Seo-Hee Rha, Jin-A Jung
Korean J Pediatr. 2006;49(10):1116-1119.   Published online October 15, 2006
Pyomyositis is a primary bacterial infection of the skeletal muscles. Although infection can affect any skeletal muscle, the large muscle groups such as the quadriceps or gluteal muscles are most often the focus of this disease, and most commonly the inflammation is focal, involving a single muscle. The mechanism of pyomyositis is poorly understood. The local mechanical trauma at the...
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