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Volume 50(2); Feb 2007
Review Articles
Fever
Taek Jin Lee, Dong Soo Kim
Korean J Pediatr. 2007;50(2):121-126.   Published online February 15, 2007
Fever has been recognized as a cardinal feature of disease since antiquity, but only recently has the pathophysiology of fever come to be understood. It became clear that the ultimate cause of fever is not a bacterial product (a so-called exogenous pyrogen) but a product of host inflammatory cells (i.e., an endogenous pyrogen). Many studies have demonstrated that mononuclear phagocytes...
Diagnostic approach to the fever of unknown origin in children - Emphasis on the infectious diseases -
Eun Hwa Choi
Korean J Pediatr. 2007;50(2):127-131.   Published online February 15, 2007
Fever of unknown origin (FUO) has been a convenient term used to classify patients who warrant a particular systemic approach to diagnostic evaluation and management. The greatest clinical concern in evaluating FUO is identifying patients whose fever has a serious or life-threatening cause when a delay in diagnosis could jeopardize successful intervention. Thorough history and complete physical examination are critical...
Fever and rash
Jin Han Kang
Korean J Pediatr. 2007;50(2):132-137.   Published online February 15, 2007
Patients with febrile illness and skin rashes need full and immediate attention. In general, these diseases show mild manifestations and good prognosis. However, causalities of some diseases with fever and rash may be life threatening or trivial. So, the differential diagnosis for those patients is extensive. A through history, a careful physical examination and close observation of clinical progress are...
Original Articles
Clinical analysis of acute drug intoxication and foreign body ingestion in Wonju: comparison between the 1990s and the 2000s
Joo Pil Eum, Jin Suk Suh, Hwang Min Kim
Korean J Pediatr. 2007;50(2):138-142.   Published online February 15, 2007
Purpose : The purpose of this study is to find out the changing pattern of drug or foreign body ingestion between 1990s and 2000s in Wonju Christian Hospital, which is located in one of the most rapidly urbanizing cities in Korea. Methods : We retrospectively reviewed the medical records of patients with acute drug intoxication and foreign body ingestion from January...
Validation of enzyme immunoassay for the quantitative measurement of human IgG antibodies specific for Haemophilus influenzae Type b capsular polysaccharide
Kyung Hyo Kim, Soo Young Lim
Korean J Pediatr. 2007;50(2):143-150.   Published online February 15, 2007
Purpose : This study was conducted to validate enzyme immunoassay (EIA) for the quantitative measurement of human IgG antibodies specific for Haemophilus influenzae type b (Hib) capsular polysaccharide. Method : We evaluated specificity, repeatability, intermediate precision, accuracy, lower limit of quantification (LLOQ), and stability to validate standardized EIA for the quantitative measurement of human anti-polyribosylribitol phosphate (PRP) IgG antibodies. Results :...
A study of serotyping of Streptococcus pneumoniae by multibead assay
Ky Young Cho, Jung Ah Lee, Sung Eun Cho, Nam Hee Kim, Jin A Lee, Ki Sook Hong, Hoan Jong Lee, Kyung Hyo Kim
Korean J Pediatr. 2007;50(2):151-156.   Published online February 15, 2007
Purpose : Streptococcus pneumoniae is a major etiologic agent for pneumonia, meningitis, otitis media, and sepsis among young children. Multi-drug resistant strains have raised great concern worldwide, thus the importance of prevention with vaccines has been emphasized. However, vaccines may force the appearance of pneumococcal infections by nonvaccine serotypes. Thus, distribution of pneumococcal serotypes should be monitored to estimate vaccine...
A clinical study of child bacterial meningitis in Daejeon and Chungcheong area : 2001-2005
Yong Joo Lee, Soo Jin Lee, Ho Jin Park, Young Hyuk Lee, So Young Kang, Young Chang Kim, In Kyu Lee, Kyung Yeon Lee, Keon Su Lee, Won Seop Kim
Korean J Pediatr. 2007;50(2):157-162.   Published online February 15, 2007
Purpose : The purpose of this study was to analyze the epidemiology, causative organism, clinical manifestation and prognosis of bacterial meningitis for children after the introduction of Haemophilus influenzae type b (Hib) vaccine in Daejeon and Chungcheong area. Methods : We analyzed retrospectively 53 medical records who had been diagnosed with bacterial meningitis at 10 general or university hospitals...
Clinicopathologic features and prognosis of childhood IgA nephropathy
Sung Il Woo, Keun Wook Bae, Joo Hoon Lee, Young Seo Park, Yong Mee Cho
Korean J Pediatr. 2007;50(2):170-177.   Published online February 15, 2007
Purpose : Clinicopathological features were investigated to clarify the outcome and prognostic indicators for patients with IgA nephropathy in Korean children. Methods : We reviewed the outcomes of 61 patients in whom IgA nephropathy was diagnosed before the age of 15 years from 1991 to 2005 and followed-up at least for one year. All patients were confirmed by renal biopsy. Results...
Renal manifestations in tuberous sclerosis complex
Il Cheon Jeong, Ji Tae Kim, You Sik Hwang, Jung A Kim, Jae Seung Lee
Korean J Pediatr. 2007;50(2):178-181.   Published online February 15, 2007
Purpose : The renal manifestations of tuberous sclerosis complex (TSC) are remarkably diverse, including polycystic kidney disease, simple renal cysts, renal cell carcinomas, and angiomyolipomas. All of these occur in children as well as adults in TSC. Angiomyolipomas, which can cause spontaneous life-threatening hemorrhages, are by far the most prevalent and the greatest source of morbidity. Here, we will address...
Comparison of growth and neuropsychological function after treatment for hematologic and oncologic diseases in monozygotic twins
Gi Hwan Kim, Hoon Kook, Hee Jo Baek, Dong Kyun Han, Eun Song Song, Young Kook Jo, Ic Sun Choi, Young Ok Kim, Chan Jong Kim, Young Jong Woo, Soo Jin Yang
Korean J Pediatr. 2007;50(2):182-189.   Published online February 15, 2007
Purpose : The primary purpose of this study was to evaluate the growth and neuropsychologic function following treatments for pediatric hematologic and oncologic diseases. Healthy monozygotic twins served as ideal controls for comparison to exclude possible confounding factors. Methods : Seven children treated with various hematologic and oncologic diseases were included in the study: acute lymphoblastic leukemia (ALL; n=2), Diamond-Blackfan anemia...
A study and the growth and the development of microvascular complications in patients with type 1 diabetes mellitus
Young Ah Lee, Kyong-Ah Yun, Choong Ho Shin, Sei Won Yang
Korean J Pediatr. 2007;50(2):190-197.   Published online February 15, 2007
Purpose : Reduced growth and microvascular complications have been recognized as consequences of type 1 diabetes mellitus (T1DM). We assessed the effect of T1DM on growth and factors associated with the development of microvascular complications. Methods : We conducted a retrospective longitudinal evaluation of 154 patients above 16 years of age. We analyzed factors which affect final height standard deviation scores...
Growth promoting effect of short-term gonadotropin releasing hormone agonist with or without growth hormone in girls with early puberty
Eun-Ju Lee, Heon-Seok Han
Korean J Pediatr. 2007;50(2):198-204.   Published online February 15, 2007
Purpose : The hope that arresting pubertal developement might increase final adult height has led to an attempt to use GnRH agonist (GnRHa) in children with early puberty and poor growth prognosis. We investigated the growth-promoting effect of GnRH agonists with or without growth hormone (GH) in girls with early puberty and decreased predicted adult height (PAH). Methods : Thirty five...
Clinical application of D-dimer in Kawasaki Disease
Jae Joon Han, Hong Ki Ko, Young Yoo, JungHwa Lee, Kwang Chul Lee, Chang Sung Son, Joo Won Lee
Korean J Pediatr. 2007;50(2):205-208.   Published online February 15, 2007
Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea Purpose : Vascular endothelial cell damage and alteration of a fibrinolytic system was suggested to play a role in the development of coronary artery abnormalities in Kawasaki disease (KD). D-dimer is one of the markers of endothelial damage and fibrinolysis. We evaluated the clinical usefulness of D- dimer to differentiate KD...
Case Reports
A case of acquired acrodermatitis enteropathica with a normal serum zinc level but a low level in the hair
Kyung Il Oh, Jung Hee Kim, Ji Eun Lee, Dae Hyun Lim, Byong Kwan Son
Korean J Pediatr. 2007;50(2):209-212.   Published online February 15, 2007
Acrodermatitis enteropathica (AE) is a rare autosomal recessive disorder of early infancy, and is characterized by periorificial dermatitis, alopecia, and intractable diarrhea. Serum zinc levels are usually low in untreated patients and the oral administration of zinc sulfate can clear skin lesions and other symptoms. Although premature and cow`s milk-fed infants are at particular risk of developing AE, there have...
Clinical improvement in a case of atypical infantile onset Pompe disease with enzyme replacement therapy
You Hoon Jeon, Baik-Lin Eun, Chang Sung Son, Dong Hwan Lee
Korean J Pediatr. 2007;50(2):213-217.   Published online February 15, 2007
Pompe disease is a genetic disorder caused by a deficiency of acid α-glucosidase (GAA). Infantile onset Pompe disease is uniformly lethal. Affected infants generally present in the first few months of life with hypotonia, generalized muscle weakness, and a hypertrophic cardiomyopathy, which is rapidly followed by death, usually by the age of one. The late-onset form is characterized less severe...
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