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Volume 51(5); May 2008
Review Articles
Ethical considerations in publication of medical papers
Chong-Woo Bae
Korean J Pediatr. 2008;51(5):447-451.   Published online May 15, 2008
It is fair to say that there are many ethical issues concerning the publication of medical papers. To define the best practice in the ethics of scientific publishing and a proper understanding of appropriate reporting in medical papers, this review should be useful for authors dealing with ethical issues which involve the protection of human and animal rights, the protection...
Epidemiology of Kawasaki disease in Korea
Yong Won Park
Korean J Pediatr. 2008;51(5):452-456.   Published online May 15, 2008
Kawasaki disease (KD) is an acute, self-limited vasculitis of unknown etiology that occurs predominantly in infants and young children. Initially described in 1967 by Dr. Tomisaku Kawasaki, it is now the most common cause of acquired heart disease among children in developed nations. Although KD has been reported across all racial and ethnic groups, the incidence of KD is more...
Update on treatment in acute stage of Kawasaki disease
Ji Whan Han
Korean J Pediatr. 2008;51(5):457-461.   Published online May 15, 2008
Kawasaki disease (KD) was first described by Dr. Tomisaku Kawasaki in his 1975 study, published in Pediatrics. Its pathogenesis is still not clearly understood. Early diagnosis and treatment are very important to preventing concomitant coronary artery complications. Most KD patients respond well to the standard treatment of aspirin and intravenous immunoglobulin; however, some of them are refractory to the standard...
Cardiovascular complications after Kawasaki disease and its management
Gi Young Jang
Korean J Pediatr. 2008;51(5):462-467.   Published online May 15, 2008
Kawasaki disease is a systemic vasculitis of unknown etiology, usually occurring in infants and young children. Although the etiology of Kawasaki disease remains uncertain, its serious complicationssuch as giant aneurysm formation, coronary arterial stenotic lesions, and thrombotic occlusionhave been proven to cause myocardial ischemia or infarction in patients with Kawasaki disease. To prevent and treat these complications, several modes of...
Original Articles
A study of mothers knowledge of weaning of infants with iron-deficiency anemia
Sung Jin Kim, Dong Hyun Kim, Joo Hee Chang, Yong Hun Jun, Young Jin Hong, Byong Kwan Son, Soon Ki Kim
Korean J Pediatr. 2008;51(5):468-473.   Published online May 15, 2008
Purpose : Iron-deficiency anemia (IDA) is still one of the most common nutrient deficiency disorders, despite improvements in general health and nutrition. This study was designed to investigate the diagnostic values of hematological profiles, including the level of ferritin, and to evaluate the knowledge of mothers on weaning practices for infants and young children with IDA. Methods : This study...
Early stress hyperglycemia as independent predictor of increased mortality in preterm infants
Young Sun Wee, Gae Hyun Ahn, Eun Gyong Yoo, In Sook Lim, Kyu Hyung Lee
Korean J Pediatr. 2008;51(5):474-480.   Published online May 15, 2008
Purpose : Stress hyperglycemia is common in critically ill adult patients. It is known as a predictor of increased mortality, and intensive insulin therapy has been shown to improve the prognosis in such patients. We have investigated the relationship between early stress hyperglycemia and clinical outcomes in preterm infants. Methods : In this study, 141 preterm infants with a gestational age...
Pain reducing effect of vapocoolant spray during injection and heelstick procedure in neonates
Eun Kyong Choi, Ji Mi Jung, Jong Beom Sin
Korean J Pediatr. 2008;51(5):481-486.   Published online May 15, 2008
Purpose : The aims of this study were to test the efficacy of vapocoolant spray to decrease the symptoms associated with pain in newborns undergoing heel stick and intramuscular injection and compare the pain relief effect of oral glucose. Methods : Randomized, controlled study including sixty newborns undergoing heel stick and intramuscular injection. Group 1 was heelsticked, Group 2 was intramuscular...
Increased vascular endothelial growth factor in children with acute Mycoplasma pneumoniae pneumonia and wheezing
Young Seo, Byung Keun Yu, Yeon Joung Oh, Yoon Lee, Young Yoo, Ji Tae Choung, Young Yull Koh
Korean J Pediatr. 2008;51(5):487-491.   Published online May 15, 2008
Purpose : Although Mycoplasma pneumoniae (M. pneumoniae) infection can cause wheezing in non-asthmatic children, the mechanisms of this symptom remain unclear. Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and vascular permeability, and is also known to be elevated in cases of chronic pulmonary disease such as asthma. We hypothesized that VEGF may increase in children with...
Gastric mucosal immune response of Helicobacter pylori-infected children
Hye Won Yom, Jeong Wan Seo
Korean J Pediatr. 2008;51(5):492-499.   Published online May 15, 2008
Purpose : Helicobacter pylori infection is one of the most common gastrointestinal infections worldwide; it almost invariably causes chronic gastritis. Pediatric studies may provide important insights into the mucosal immune response of H. pylori-infection, as children are not submitted to environmental factors such as alcohol, tobacco and anti-inflammatory medication. The aim of the present study was to investigate the mucosal...
Clinical features of transient small bowel intussusception in children
Ji Seung Heo, Eun Min Seo, Eun Jung Shim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo, Kwan Seop Lee
Korean J Pediatr. 2008;51(5):500-505.   Published online May 15, 2008
Purpose : We analyzed the clinical features, management and outcome of small bowel intussusception in children compared with ileocolic intussusception. Methods : We retrospectively reviewed the records of 210 children with documented intussusception, in whom intussusception was initially diagnosed by ultrasonography during the four-year period of 2002 to 2005. Results : A total of 191 children were diagnosed with ileocolic intussusception and...
The effect of education and training with balloons on pulmonary function test in children
Yong Hee Hong, Sun Mi Ha, You Hoon Jeon, Hyeon Jong Yang, Bok Yang Pyun
Korean J Pediatr. 2008;51(5):506-511.   Published online May 15, 2008
Purpose : The results of pulmonary function test (PFT) in children are variable according to the patient's cooperation and comprehensiveness. This study has intended to figure out the effectiveness of pre-education and training with balloons on PFT in children. Methods : One hundred six children mean aged 9.35?.92 years were tested. All participants performed PFT twice in 30 minutes intervals....
The characteristics of neurocardiogenic syncope in children
Kyung Yeon Lee, Jin Young Lee, Myoung Hyun Kim, Jeong Eun Lee, Yong Dae Kim, Eun Ju Lee, Young Su Lim, Won Seop Kim
Korean J Pediatr. 2008;51(5):512-517.   Published online May 15, 2008
Purpose : Syncope is relatively common in children and adolescents. Among the etiologies of syncope, neurocardiogenical syncope is the most common, but it is often confounded with seizure. We investigated the clinical features of patients under the age of 15 with neurocardiogenical syncope, compared to patients with neurologic disorders including epilepsy. Methods : Among the children who visited the...
An epidemiological study on enuresis in children of two elementary schools in Suwon
Hyun Jung Lee, Kang Gyoon Lee, Eun Jin Kim, Ki-Soo Pai, Sang Don Lee
Korean J Pediatr. 2008;51(5):518-522.   Published online May 15, 2008
Purpose : The purpose of this study was to investigate the prevalence of enuresis in association with voiding habits and socioeconomic status in elementary school children. Methods : A dynamic survey was done of 1,514 students from two elementary schools in Suwon, Korea in December 2006. Data regarding gender, age, height and weight, voiding habits, and monthly family incomes were...
Transforming growth factor-β gene promoter polymorphism : its association with renal involvement in Henoch-Sch lein Purpura in childhood
Seung Ho Lee, Hwa Young Jee, Hwang Min Kim, Byung Il Yeh
Korean J Pediatr. 2008;51(5):523-527.   Published online May 15, 2008
Purpose : Several cytokines play important roles in the inflammatory process of Henoch-Sch lein Purpura (HSP). It is likely that transforming growth factor-β (TGF-β) is involved in the pathogenesis of HSP. The purpose of this study is to investigate whether TGF-β promoter polymorphism is associated with the renal involvement of childhood HSP. Methods : Thirty-four patients younger than 15 years, who...
Case Reports
Autoimmune hepatitis and thyroiditis associated with antituberculous medications : A case report
Seong Keun Yu, Sara Kim, Jin Soo Moon, Han Seong Kim
Korean J Pediatr. 2008;51(5):528-532.   Published online May 15, 2008
Drug-induced toxic hepatitis is a relatively common hepatic disease in children, and it is usually self-limiting upon cessation of the offending drugs. Antituberculous drugs are well known for inducing hepatitis. Some cases of drug-induced hepatitis with autoimmune features have been reported; in these cases, the offending drugs were usually methyldopa, nitrofurantoin, minocycline, and interferon. The authors report the first case...
Two cases of central nervous system complications caused by Mycoplasma pneumoniae infection
Shin Mi Kim, Ji Seung Heo, Eun Jung Shim, Dae Hyoung Lee, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo
Korean J Pediatr. 2008;51(5):533-537.   Published online May 15, 2008
Mycoplasma pneumoniae (M. pneumoniae) infection causes a wide variety of clinical manifestations in children and young adults, the main one being pneumonia. M. pneumoniae is transmitted from person to person by infected respiratory droplets. Symptoms caused by M. pneumoniae infection can be divided into those involving the respiratory tract, and those caused by extrapulmonary disease. M. pneumoniae infections may cause...
A case of Menkes disease with unusual hepatomegaly
Go Un Jeong, Anna Cho, Hee Hwang, Yong Seung Hwang, Ki Joong Kim, Jong Hee Chae, Jeong Kee Seo
Korean J Pediatr. 2008;51(5):538-541.   Published online May 15, 2008
Menkes disease is an X-linked recessive copper transport disorder characterized by neurological deterioration, connective- tissue damage, and abnormal hair growth. It is caused by the mutation of the ATP7A gene. This report describes a four- month-old boy with neurological symptoms typical of Menkes disease plus unusual liver involvement. He developed seizures at three months of age and exhibited hypotonia, cephalhematoma,...
A case of Kawasaki disease preceding a retropharyngeal abscess
Hee Ok Park, Jae Woo Lim, Eun Jung Cheon, Kyung Ok Ko
Korean J Pediatr. 2008;51(5):542-545.   Published online May 15, 2008
Epidural hematoma (EDH) is relatively rare in newborn infants and frequently associated with instrumental deliveries or other complications during labor and delivery. Although surgical evacuation has been the most common therapy, many other procedures have been suggested. Although many epidural hematomas require surgical evacuation rather than non-surgical management, the conservatiob or aspiration of hematoma have been attempted. In the case...
A case of two sisters births from mother with phenylketonuria lacking mental retardation
Chang-Seok Ki, Jin Kyung Kim
Korean J Pediatr. 2008;51(5):546-550.   Published online May 15, 2008
In this untreated classic phenylketonuria (PKU) case, mental retardation is severe; however, there have been individuals­like the mother of this case­who have escaped mental retardation and all the other potential sequelae of phenylketonuria, despite having high blood phenylalanine levels, and very poor dietary control. It appears that they have nearly normal brain phenylalanine levels despite high blood phenylalanine (Phe) levels....
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