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Volume 54(8); Aug 2011
Review Articles
Treatment of steroid-resistant pediatric nephrotic syndrome
Hee Gyung Kang
Korean J Pediatr. 2011;54(8):317-321.   Published online August 31, 2011

Children who suffer from steroid-resistant nephrotic syndrome (SRNS) require aggressive treatment to achieve remission. When intravenous high-dose methylprednisolone fails, calcineurin inhibitors, such as cyclosporine and tacrolimus, are used as the first line of treatment. A significant number of patients with SRNS progress to end-stage renal disease if remission is not achieved. For these children, renal replacement therapy can also be...

Complications of nephrotic syndrome
Se Jin Park, Jae Il Shin
Korean J Pediatr. 2011;54(8):322-328.   Published online August 31, 2011

Nephrotic syndrome (NS) is one of the most common glomerular diseases that affect children. Renal histology reveals the presence of minimal change nephrotic syndrome (MCNS) in more than 80% of these patients. Most patients with MCNS have favorable outcomes without complications. However, a few of these children have lesions of focal segmental glomerulosclerosis, suffer from severe and prolonged proteinuria, and...

Original Articles
Clinical characteristics and outcomes among pediatric patients hospitalized with pandemic influenza A/H1N1 2009 infection
Eun Lee, Ju-Hee Seo, Hyung-Young Kim, Shin Na, Sung-Han Kim, Ji-Won Kwon, Byoung-Ju Kim, Soo-Jong Hong
Korean J Pediatr. 2011;54(8):329-334.   Published online August 31, 2011
Purpose

The purpose of this article is to describe the clinical and epidemiologic features and outcomes among children hospitalized with pandemic influenza A/H1N1 2009 infection.

Methods

We retrospectively reviewed the charts of hospitalized pediatric patients (<18 years) diagnosed with pandemic influenza A/H1N1 2009 infection by reverse-transcriptase polymerase chain reaction at a tertiary hospital in Seoul, Korea, between September 2009 and February 2010.

Results

A total...

Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population
Kyung Lim Yoon, Jin Hee Ko, Kye Shik Shim, Mi Young Han, Sung Ho Cha, Su Kang Kim, Joo Ho Jung
Korean J Pediatr. 2011;54(8):335-339.   Published online August 31, 2011
Purpose

Hyperhomocysteinemia is known as a risk factor for atherosclerosis. Preclinical arteriosclerosis is noted and premature atherosclerosis is known to be accelerated in Kawasaki disease (KD) patients. Genetic polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene result in elevated plasma homocysteine concentrations and are known to be associated with the development of coronary artery disease. Our hypothesis is that single nucleotide polymorphisms...

Log-transformed plasma level of brain natriuretic peptide during the acute phase of Kawasaki disease is quantitatively associated with myocardial dysfunction
Sunhee Bang, Jeong Jin Yu, Myung-Ki Han, Hong Ki Ko, Sail Chun, Hyung Soon Choi, Young-Hwue Kim, Jae-Kon Ko, In-Sook Park
Korean J Pediatr. 2011;54(8):340-344.   Published online August 31, 2011
Purpose

Brain natriuretic peptide (BNP) has been considered a biochemical marker for myocarditis in Kawasaki disease. We performed this study to determine its quantitative significance.

Methods

We attempted to correlate log-transformed BNP concentrations (log-BNP) and clinical, laboratory, and echocardiographic variables in 81 children with Kawasaki disease. Stepwise multiple linear regression analysis was used to determine the variables independently associated with log-BNP concentration.

Results

Serum C-reactive...

Case Reports
2009 H1N1 influenza virus infection and necrotizing pneumonia treated with extracorporeal membrane oxygenation
Suntae Ji, Ok Jeong Lee, Ji-Hyuk Yang, Kangmo Ahn, Joongbum Cho, Soo In Jeong, Woo-sik Han, Yae-Jean Kim
Korean J Pediatr. 2011;54(8):345-349.   Published online August 31, 2011

A 3-year-old girl with acute respiratory distress syndrome due to a H1N1 2009 influenza virus infection was complicated by necrotizing pneumonia was successfully treated with extracorporeal membrane oxygenation (ECMO). This is the first reported case in which a pediatric patient was rescued with ECMO during the H1N1 influenza epidemic in Korea in 2009.

Masticator space abscess in a 47-day-old infant
Eunhee Kim, Ju Hee Jeon, Yoon Hee Shim, Kyu-Seok Lee, So Young Kim, Eun Ryoung Kim
Korean J Pediatr. 2011;54(8):350-353.   Published online August 31, 2011

A 47-day-old male infant presented with fever, poor oral intake, irritability, and right-sided bluish buccal swelling. Contrast-enhanced computed tomography of the neck showed a round mass lesion of about 2.0×1.5 cm that suggested abscess formation in the right masticator space. Ultrasound-guided extraoral aspiration of the abscess at the right masseter muscle was successful. Staphylococcus aureus was identified in the culture...

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