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Volume 56(5); May 2013
Review Articles
Phenotypes and endotypes of severe asthma in children
Young Yoo
Korean J Pediatr. 2013;56(5):191-195.   Published online May 28, 2013

Severe childhood asthma is a complicated and heterogeneous disorder with distinct phenotypes. Children with severe asthma have more persistent symptoms despite receiving treatment, more atopy, greater airway obstruction, and more air trapping than those with mild-to-moderate asthma. They also have higher morbidity and substantial airflow limitations that persist throughout adulthood. Identification of the phenotype clusters and endotypes of severe asthma...

Systemic use of fluoroquinolone in children
Soo-Han Choi, Eun Young Kim, Yae-Jean Kim
Korean J Pediatr. 2013;56(5):196-201.   Published online May 28, 2013

Fluoroquinolones are an important class of antibiotics that are widely used in adult patients because of their broad spectrum of activity, good tissue penetration, and oral bioavailability. However, fluoroquinolone use in children is limited because juvenile animals developed arthropathy in previous experiments on fluoroquinolone use. Indications for fluoroquinolone use in patients younger than 18 years, as stated by the U.S....

Original Articles
Vitamin D deficiency in infants aged 1 to 6 months
You Jin Choi, Moon Kyu Kim, Su Jin Jeong
Korean J Pediatr. 2013;56(5):205-210.   Published online May 28, 2013
Purpose

The aim of this study was to recognize the state of vitamin D among healthy infants aged 1 to 6 months in South Korea, and also to identify the risk factors affecting the level of vitamin D.

Methods

A total of 117 infants were enrolled in this study for 12 months, from March 1, 2011 to February 29, 2012. Serum levels of...

Depression and marital intimacy level in parents of infants with sleep onset association disorder: a preliminary study on the effect of sleep education
Sihyoung Lee, Seonkyeong Rhie, Kyu Young Chae
Korean J Pediatr. 2013;56(5):211-217.   Published online May 28, 2013
Purpose

Sleep onset association disorder (SOAD) is a form of behavioral insomnia observed in children that is caused by inappropriate sleep training. SOAD typically disturbs the sleep of not only infants and children but also their parents. We investigated levels of depression and marital intimacy among parents of infants with typical SOAD, to understand the influence of SOAD on family dynamics,...

Serum levels of interleukin-6 and interleukin-8 as diagnostic markers of acute pyelonephritis in children
Abolfazl Mahyar, Parviz Ayazi, Mohammad Reza Maleki, Mohammad Mahdi Daneshi-Kohan, Hamid Reza Sarokhani, Hassan Jahani Hashemi, Mousa Talebi-Bakhshayesh
Korean J Pediatr. 2013;56(5):218-223.   Published online May 28, 2013
Purpose

Early diagnosis and treatment of acute pyelonephritis in children is of special importance in order to prevent serious complications. This study was conducted to determine the diagnostic value of serum interleukin (IL)-6 and IL-8 in children with acute pyelonephritis.

Methods

Eighty-seven patients between 1 month to 12 years old with urinary tract infection (UTI) were divided into 2 groups based on the...

Case Reports
Liver transplantation in a child with acute liver failure resulting from drug rash with eosinophilia and systemic symptoms syndrome
Seung Min Song, Min Sung Cho, Seak Hee Oh, Kyung Mo Kim, Young Seo Park, Dae Yeon Kim, Sung Gyu Lee
Korean J Pediatr. 2013;56(5):224-226.   Published online May 28, 2013

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is characterized by a severe idiosyncratic reaction including rash and fever, often with associated hepatitis, arthralgias, lymph node enlargement, or hematologic abnormalities. The mortality rate is approximately 10%, primarily owing to liver failure with massive or multiple disseminated focal necrosis. Here, we report a case of a 14-year-old girl treated with...

Two cases of chronic pancreatitis associated with anomalous pancreaticobiliary ductal union and SPINK1 mutation
Eun Sam Rho, Earl Kim, Hong Koh, Han-Wook Yoo, Beom Hee Lee, Gu-Hwan Kim
Korean J Pediatr. 2013;56(5):227-230.   Published online May 28, 2013

Chronic pancreatitis is a progressive inflammatory disease resulting from repeated episodes of acute pancreatitis that impair exocrine function and eventually produce endocrine insufficiency. Some causes of chronic pancreatitis appear to be associated with alterations in the serine-protease inhibitor, Kazal type 1 (SPINK1), cationic trypsinogen (PRSS1), and cystic fibrosis-transmembrane conductance regulator (CFTR) genes, or with structural disorders in the pancreaticobiliary ductal...

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