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Volume 57(2); Feb 2014
Review Articles
Efficacy and effectiveness of extended-valency pneumococcal conjugate vaccines
Hyunju Lee, Eun Hwa Choi, Hoan Jong Lee
Korean J Pediatr. 2014;57(2):55-66.   Published online February 24, 2014

The 7-valent pneumococcal protein conjugate vaccine (PCV7) has been shown to be highly efficacious against invasive pneumococcal diseases and effective against pneumonia and in reducing otitis media. The introduction of PCV7 has resulted in major changes in the epidemiology of pneumococcal diseases. However, pneumococcal vaccines induce serotype-specific immunity, and a relative increase in non-vaccine serotypes has been reported following the...

Antibiotics resistance of Helicobacter pylori and treatment modalities in children with H. pylori infection
Ji-Hyun Seo, Hyang-Ok Woo, Hee-Shang Youn, Kwang-Ho Rhee
Korean J Pediatr. 2014;57(2):67-71.   Published online February 24, 2014

Pediatric infection with Helicobacter pylori may occur early in childhood and persist lifelong. Global pediatric clinical studies have reported a decreasing tendency in the overall rate of H. pylori eradication. In pediatric patients with H. pylori infection, pediatric patients with peptic ulcer, and the first-degree relatives of patients with a history of gastric cancer, it is commonly recommended that H....

Editorial
Head circumference alone at birth, is it practical?
Young-Hoon Kim
Korean J Pediatr. 2014;57(2):72-74.   Published online February 24, 2014
Original Articles
Clinical features of macrocephaly at birth in Korea
Goun Jeong, Minkyun Kim, Byoung Hee Han
Korean J Pediatr. 2014;57(2):75-78.   Published online February 24, 2014
Purpose

This study aimed to investigate the clinical features of macrocephaly at birth in Korea using ultrasonography.

Methods

We retrospectively investigated the medical records of full-term birth neonates in Cheil General Hospital & Women's Healthcare Center from January 2000 to June 2012. The following parameters were recorded and analyzed: gestational age, sex, birth weight, height, occipitofrontal circumference (OFC), physical examination, perinatal problems, and...

The association of blood pressure with body mass index and waist circumference in normal weight and overweight adolescents
Young-Hwan Song
Korean J Pediatr. 2014;57(2):79-84.   Published online February 24, 2014
Purpose

Overweight can be defined by the body mass index (BMI) and is likely associated with an increased cardiovascular disease risk. However, waist circumference (WC), a central adiposity index, may be a better indicator of cardiovascular disease risk. Studies comparing the effects of BMI and WC on cardiovascular risk factors, such as high blood pressure (BP), are rare in adolescents.

Methods

We analyzed...

Characteristics of thyroid nodules in infant with congenital hypothyroidism
Seo Young Youn, Jeong Ho Lee, Yun-Woo Chang, Dong Hwan Lee
Korean J Pediatr. 2014;57(2):85-90.   Published online February 24, 2014
Purpose

This study aimed to assess the characteristics of thyroid nodules among infants diagnosed with congenital hypothyroidism.

Methods

A retrospective study of 660 infants (374 males, 286 females) diagnosed with congenital hypothyroidism was carried out at the Pediatric Endocrine Clinic in Soonchunhyang University Hospital, Korea, between May 2003 and February 2013. The average age at diagnosis was 1.16±1.68 months.

Results

Of the 28 patients (4.2%)...

Case Reports
Griscelli syndrome type 2: a novel mutation in RAB27A gene with different clinical features in 2 siblings: a diagnostic conundrum
Kirtisudha Mishra, Shilpy Singla, Suvasini Sharma, Renu Saxena, Vineeta Vijay Batra
Korean J Pediatr. 2014;57(2):91-95.   Published online February 24, 2014

Griscelli syndrome type 2 (GS2) is a rare autosomal recessive disease caused by mutations in the RAB27A gene. It is characterized by cutaneous hypopigmentation, immunodeficiency, and hemophagocytic lymphohistiocytosis. We describe 2 brothers who had GS2 with clinically diverse manifestations. The elder brother presented with a purely neurological picture, whereas the younger one presented with fever, pancytopenia, hepatosplenomegaly, and erythema nodosum....

Shiga toxin-associated hemolytic uremic syndrome complicated by intestinal perforation in a child with typical hemolytic uremic syndrome
Hye Jin Chang, Hwa Young Kim, Jae Hong Choi, Hyun Jin Choi, Jae Sung Ko, Il Soo Ha, Hae Il Cheong, Yong Choi, Hee Gyung Kang
Korean J Pediatr. 2014;57(2):96-99.   Published online February 24, 2014

Hemolytic uremic syndrome (HUS) is one of the most common causes of acute renal failure in childhood and is primarily diagnosed in up to 4.5% of children who undergo chronic renal replacement therapy. Escherichia coli serotype O157:H7 is the predominant bacterial strain identified in patients with HUS; more than 100 types of Shiga toxin-producing enterohemorrhagic E. coli (EHEC) subtypes have...

Correspondence
Erratum: Changes in the neonatal and infant mortality rate and the causes of death in Korea
Sung-Hoon Chung, Yong-Sung Choi, Chong-Woo Bae
Korean J Pediatr. 2014;57(2):100-100.   Published online February 24, 2014
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