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Volume 58(11); Nov 2015
Review Article
Early-onset epileptic encephalopathies and the diagnostic approach to underlying causes
Su-Kyeong Hwang, Soonhak Kwon
Korean J Pediatr. 2015;58(11):407-414.   Published online November 22, 2015

Early-onset epileptic encephalopathies are one of the most severe early onset epilepsies that can lead to progressive psychomotor impairment. These syndromes result from identifiable primary causes, such as structural, neurodegenerative, metabolic, or genetic defects, and an increasing number of novel genetic causes continue to be uncovered. A typical diagnostic approach includes documentation of anamnesis, determination of seizure semiology, electroencephalography, and...

Original Articles
Low levels of tissue inhibitor of metalloproteinase-2 at birth may be associated with subsequent development of bronchopulmonary dysplasia in preterm infants
Choae Lee, Jaewoo An, Ji Hee Kim, Eun Sun Kim, Soo Hyun Kim, Yeon Kyung Cho, Dong Hyun Cha, Man Yong Han, Kyu Hyung Lee, Youn Ho Sheen
Korean J Pediatr. 2015;58(11):415-420.   Published online November 22, 2015
Purpose

Bronchopulmonary dysplasia (BPD) is characterized by inflammation with proteolytic damage to the lung extracellular matrix. The results from previous studies are inconsistent regarding the role of proteinases and antiproteinases in the development of BPD. The aim of the present study was to investigate whether matrix metalloproteinase (MMP)-8, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-2, and TIMP-1 levels in the serum of...

Usefulness of serum cystatin C to determine the dose of vancomycin in neonate
Jeong Eun Shin, Soon Min Lee, Ho Seon Eun, Min Soo Park, Kook In Park, Ran Namgung
Korean J Pediatr. 2015;58(11):421-426.   Published online November 22, 2015
Purpose

The vancomycin dosage regimen is regularly modified according to the patient's glomerular filtration rate (GFR). In the present study, we aimed to assess the usefulness of serum cystatin C (Cys-C) concentration, compared with serum creatinine (SCr) concentration, for predicting vancomycin clearance (CLvcm) in neonates.

Methods

We retrospectively analyzed the laboratory data of 50 term neonates who were admitted to the neonatal intensive...

Severe vitamin D deficiency in preterm infants: maternal and neonatal clinical features
Sook-Hyun Park, Gi-Min Lee, Jung-Eun Moon, Heng-Mi Kim
Korean J Pediatr. 2015;58(11):427-433.   Published online November 22, 2015
Purpose

We investigated the vitamin D status of preterm infants to determine the incidence of vitamin D deficiency.

Methods

A total of 278 preterm infants delivered at Kyungpook National University Hospital between January 2013 and May 2015 were enrolled. The serum concentrations of calcium, phosphorous, alkaline phosphatase, and 25-hydroxyvitamin D (25-OHD) were measured at birth. We collected maternal and neonatal data such as...

Sensorineural hearing loss in patients with Kawasaki disease
Sun Young Park, Young Hyun Kim, Yeo Hyang Kim, Myung Chul Hyun, Young Hwan Lee
Korean J Pediatr. 2015;58(11):434-439.   Published online November 22, 2015
Purpose

Kawasaki disease involves acute febrile systemic vasculitis that can cause a variety of symptoms by affecting various organs. Here, we aimed to evaluate the prevalence, causes, and prognosis of sensorineural hearing loss (SNHL) occurring in children with Kawasaki disease.

Methods

Patients who were diagnosed with Kawasaki disease and received inpatient treatment in the Pediatrics Department at one of three university hospitals in...

Analysis of clinical characteristics and causes of chest pain in children and adolescents
Ji Hye Chun, Tae Hyeong Kim, Mi Young Han, Na Yeon Kim, Kyung Lim Yoon
Korean J Pediatr. 2015;58(11):440-445.   Published online November 22, 2015
Purpose

Chest pain is common in children and adolescents and is a reason for referral to pediatric cardiologists. Although most cases of chest pain in these age groups are benign and do not require treatment, timely diagnosis is important not to miss life-threatening diseases requiring prompt treatment. We investigated certain clinical characteristics that may be useful in the diagnosis of such...

Analysis of clinical information and reverse transcriptase-polymerase chain reaction for early diagnosis of enteroviral meningitis
Dahee Jin, Tae Hoon Heo, Jung Hye Byeon, Gun-Ha Kim, Mi Kyung Kim, So-Hee Eun, Baik-Lin Eun
Korean J Pediatr. 2015;58(11):446-450.   Published online November 22, 2015
Purpose

Meningitis is among the most common infections affecting the central nervous system. It can be difficult to determine the exact pathogen responsible for the infection and patients are often treated with empiric antibiotics. This study was conducted to identify the most common clinical characteristics of enteroviral meningitis in children and evaluate the diagnostic efficacy of reverse transcriptase-polymerase chain reaction (RT-PCR)...

Case Reports
Diphyllobothrium latum infection in a child with recurrent abdominal pain
Seung Hyun Lee, Hyun Park, Seung Taek Yu
Korean J Pediatr. 2015;58(11):451-453.   Published online November 22, 2015

Diphyllobothrium latum infection in humans is not common in Republic of Korea. We report a case of fish tapeworm infection in a 10-year-old boy after ingestion of raw perch about 8 months ago. The patient complained of recurrent abdominal pain and watery diarrhea. A tapeworm, 85 cm in length, without scolex and neck, was spontaneously discharged in the feces of...

Compartment syndrome due to extravasation of peripheral parenteral nutrition: extravasation injury of parenteral nutrition
Huee Jin Park, Kyung Hoon Kim, Hyuk Jin Lee, Eui Cheol Jeong, Kee Won Kim, Dong In Suh
Korean J Pediatr. 2015;58(11):454-458.   Published online November 22, 2015

Compartment syndrome is a rare but devastating condition that can result in permanent neuromuscular or soft tissue injuries. Extravasation injuries, among the iatrogenic causes of compartment syndrome, occur under a wide variety of circumstances in the inpatient setting. Total parenteral nutrition via a peripheral route is an effective alternative for the management of critically ill children who do not obtain...

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