Article 55(1); Jan 2012
Review Articles
An overview of the national immunization policy making process: the role of the Korea expert committee on immunization practices
Hee Yeon Cho
Clin Exp Pediatr. 2012;55(1):1-5.   Published online January 31, 2012

The need for evidence-based decision making in immunization programs has increased due to the presence of multiple health priorities, limited human resources, expensive vaccines, and limited funds. Countries should establish a group of national experts to advise their Ministries of Health. So far, many nations have formed their own National Immunization Technical Advisory Groups (NITAGs). In the Republic of Korea,...

The genes associated with gonadotropin-releasing hormone-dependent precocious puberty
Jin Soon Hwang
Clin Exp Pediatr. 2012;55(1):6-10.   Published online January 31, 2012

Human puberty is a complex, coordinated biological process with multiple levels of regulations. The timing of puberty varies greatly in children and is influenced by both environmental and genetic factors. The key genes of pubertal onset, KISS1, GPR54, GNRH1 and GNRHR, may be major causal factors underlying gonadotropin-releasing hormone-dependent precocious puberty (GDPP). Two gain-of-function mutations in KISS1 and GPR54 have...

Original Articles
Comparison of the accuracy of neutrophil CD64 and C-reactive protein as a single test for the early detection of neonatal sepsis
Young Kwang Choo, Hyun-Seok Cho, In Bum Seo, Hyeon-Soo Lee
Clin Exp Pediatr. 2012;55(1):11-17.   Published online January 31, 2012
Purpose

Early identification of neonatal sepsis is a global issue because of limitations in diagnostic procedures. The objective of this study was to compare the diagnostic accuracy of neutrophil CD64 and C-reactive protein (CRP) as a single test for the early detection of neonatal sepsis.

Methods

A prospective study enrolled newborns with documented sepsis (n=11), clinical sepsis (n=12) and control newborns (n=14). CRP,...

Transforming growth factor beta receptor II polymorphisms are associated with Kawasaki disease
Yu Mi Choi, Kye Sik Shim, Kyung Lim Yoon, Mi Young Han, Sung Ho Cha, Su Kang Kim, Joo Ho Jung
Clin Exp Pediatr. 2012;55(1):18-23.   Published online January 31, 2012
Purpose

Transforming growth factor beta receptor 2 (TGFBR2) is a tumor suppressor gene that plays a role in the differentiation of striated cells and remodeling of coronary arteries. Single nucleotide polymorphisms (SNPs) of this gene are associated with Marfan syndrome and sudden death in patients with coronary artery disease. Cardiovascular remodeling and T cell activation of TGFBR2 gene suggest that the...

Case Reports
Partial anomalous pulmonary venous connection with intact atrial septum in a child with ventricular septal defect: a case report
Young Nam Kim, Hwa Jin Cho, Young Kuk Cho, Jae Sook Ma
Clin Exp Pediatr. 2012;55(1):24-28.   Published online January 31, 2012

Partial anomalous pulmonary vein connection (PAPVC) is a rare congenital abnormal cardiac defect involving the pulmonary veins draining into the right atrium (RA) directly or indirectly by venous connection. Ninety percent of PAPVCs are accompanied by atrial septal defect (ASD). To our knowledge, there is no previous report of PAPVC with ventricular septal defect (VSD) without ASD in Korea, and...

PHACE association with intracranial, oropharyngeal hemangiomas, and an atypical patent ductus arteriosus arising from the tortuous left subclavian artery in a premature infant
Do-Hyun Kim, Jang Hwan Choi, Jung Ha Lee, Hee Sup Kim
Clin Exp Pediatr. 2012;55(1):29-33.   Published online January 31, 2012

PHACE association is a rare neurocutaneous condition in which facial hemangiomas associate with a spectrum of posterior fossa malformations, arterial cerebrovascular anomalies, cardiovascular anomalies, and eye anomalies. We reported a case of PHACE association in a premature infant showing facial, intracranial, and oropharyngeal hemangiomas with evidence of the Dandy-Walker variant and complicated cardiovascular anomalies, including a right-sided aortic arch and...

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