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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">CEP</journal-id>
<journal-title-group>
<journal-title>Clinical and Experimental Pediatrics</journal-title><abbrev-journal-title>Clin Exp Pediatr</abbrev-journal-title></journal-title-group>
<issn pub-type="epub">2713-4148</issn>
<publisher>
<publisher-name>Korean Pediatric Society</publisher-name></publisher></journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3345/cep.2020.01473</article-id>
<article-id pub-id-type="publisher-id">cep-2020-01473</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Perspective</subject>
<subj-group subj-group-type="heading">
<subject>Infection</subject>
</subj-group></subj-group></article-categories>
<title-group>
<article-title>Addressing children&#x02019;s health amid the coronavirus disease 2019 pandemic</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-2733-0715</contrib-id>
<name><surname>Choe</surname><given-names>Young June</given-names></name>
<degrees>MD</degrees>
<degrees>PhD</degrees>
<xref ref-type="corresp" rid="c1-cep-2020-01473"/>
<xref ref-type="aff" rid="af1-cep-2020-01473"><sup>1</sup></xref>
<xref ref-type="aff" rid="af2-cep-2020-01473"><sup>2</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Aurang Zeb Durrani</surname><given-names>Bilal</given-names></name>
<degrees>MBA</degrees>
<xref ref-type="aff" rid="af1-cep-2020-01473"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Swartling Peterson</surname><given-names>Stefan</given-names></name>
<degrees>MD</degrees>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="af3-cep-2020-01473"><sup>3</sup></xref>
<xref ref-type="aff" rid="af4-cep-2020-01473"><sup>4</sup></xref>
</contrib>
<aff id="af1-cep-2020-01473">
<label>1</label>United Nations Children's Fund (UNICEF) Seoul Office, Seoul, <country>Korea</country></aff>
<aff id="af2-cep-2020-01473">
<label>2</label>Hallym University College of Medicine, Chuncheon, <country>Korea</country></aff>
<aff id="af3-cep-2020-01473">
<label>3</label>United Nations Children's Fund (UNICEF) Headquarters, New York, NY, <country>USA</country></aff>
<aff id="af4-cep-2020-01473">
<label>4</label>Department of Women’s and Children’s Health (IMCH), Uppsala University, Uppsala, <country>Sweden</country></aff>
</contrib-group>
<author-notes>
<corresp id="c1-cep-2020-01473">Corresponding author: Young June Choe, MD, PhD. Department of Social and Preventive Medicine, Hallym University College of Medicine, 1, Hallymdaehak-gil, Chuncheon 24252, Korea Email: <email>ychoe@hallym.ac.kr</email></corresp>
</author-notes>
<pub-date pub-type="collection">
<month>2</month>
<year>2021</year></pub-date>
<pub-date pub-type="epub">
<day>15</day>
<month>12</month>
<year>2020</year></pub-date>
<volume>64</volume>
<issue>2</issue>
<fpage>46</fpage>
<lpage>48</lpage>
<history>
<date date-type="received">
<day>30</day>
<month>08</month>
<year>2020</year></date>
<date date-type="rev-recd">
<day>30</day>
<month>11</month>
<year>2020</year></date>
<date date-type="accepted">
<day>2</day>
<month>12</month>
<year>2020</year></date>
</history>
<permissions>
<copyright-statement>Copyright &#x000a9; 2021 by The Korean Pediatric Society</copyright-statement>
<copyright-year>2021</copyright-year>
<license>
<license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions>
</article-meta>
<notes>
<title>Key message</title>
<boxed-text>
<p>In the coronavirus disease 2019 (COVID-19) pandemic, children experience heightened barriers to health and protective services. Children may also be disproportionately affected due to their reliance on the education system for daily tasks and lack of access to remote learning options. Republic of Korea findings on how vaccination coverage could be sustained in children and schools could be reopened without aggravating COVID-19 underlie the need for coordinated efforts across sectors.</p>
</boxed-text>
</notes>
</front>
<body>
<p>The global coronavirus disease 2019 (COVID-19) crisis has brought unprecedented changes in children&#x02019;s routines due to social distancing and confinement. Current data indicate that children are less vulnerable to COVID-19 &#x0005b;<xref ref-type="bibr" rid="b1-cep-2020-01473">1</xref>&#x0005d;. However, the indirect impacts of constrained health systems, limited access to preventative services like vaccinations, childcare disruptions, school closures, and household loss of income, are considerable. Thus, it is critically important to address collateral impacts on children when discussing strategies for mitigating COVID-19.</p>
<p>In many places, COVID-19 has forced the discontinuation of regular health services by overwhelming health system capacities &#x0005b;<xref ref-type="bibr" rid="b2-cep-2020-01473">2</xref>&#x0005d;. Furthermore, infection control procedures designed to reduce severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus transmission have decreased access to other health services and halted the delivery of some essential childcare services. Specifically, the interruption of immunization services may increase child morbidity and mortality rates in the medium to long term. To date, routine childhood immunization services have been disrupted globally, with more than half of the 129 countries reporting disruptions to vaccination services during March and April 2020 &#x0005b;<xref ref-type="bibr" rid="b3-cep-2020-01473">3</xref>&#x0005d;. These disruptions occurred not only in low- and middle-income countries; rather, even high-income countries like the United States experienced a decline in vaccination coverage following the declaration of national emergency in March 2020 &#x0005b;<xref ref-type="bibr" rid="b4-cep-2020-01473">4</xref>&#x0005d;. In contrast, the vaccination coverage was relatively sustained in the Republic of Korea. Compared to corresponding months in 2019, minimal decreases in vaccination coverage rates were noted in January to March 2020: vaccines for infants aged &lt;12 months (Bacille Calmette-Gu&#x000e9;rin, hepatitis B, diphtheria-tetanus-acellular pertussis &#x0005b;DTaP&#x0005d;, inactivated polio vaccines) sustained coverages at 97%&#x02013;98% in 2020; the first measles-mumps-rubella vaccine dose from 95.9% (2019) to 95.0% (2020), the fourth DTaP vaccine dose from 90% (2019) to 87% (2020), and the fourth Japanese encephalitis vaccine dose from 88% (2019) to 86% (2020) &#x0005b;<xref ref-type="bibr" rid="b5-cep-2020-01473">5</xref>&#x0005d;. The smaller decline in vaccination coverage in Korean children suggests that system-level strategies to maintain well childcare and immunization are in place (<xref rid="t1-cep-2020-01473" ref-type="table">Table 1</xref>). Sustained vaccination coverage in children reflects the success of previous strategies to promote the expansion of childhood vaccinations including outreach to private clinics and a school-based certificate system. With the long-standing history of the universal vaccination program supported by public funding in Korea, the system has evolved to incorporate evidence-based policy making through a national immunization technical advisory group. Vaccination registrations are mandated for reimbursement to the private sector; for the next vaccination schedule, a text message is routinely sent for reminder-recall purposes &#x0005b;<xref ref-type="bibr" rid="b6-cep-2020-01473">6</xref>&#x0005d;. This community-based partnership between the public and privatized system has enabled this sustained level of vaccination coverage during the COVID-19 pandemic.</p>
<p>As of July 13, 2020, 109 countries had implemented country-wide school closures to mitigate the COVID-19 pandemic, affecting an estimated 60.5% of students globally &#x0005b;<xref ref-type="bibr" rid="b7-cep-2020-01473">7</xref>&#x0005d;. School closures worsen the learning gap since children from poorer families fall further behind, while wealthier children may continue schooling using digital tools. Moreover, many children who rely on school meals are deprived. As one of the earliest hit countries with COVID-19, the Republic of Korea closed most schools until May 2020 and began the first stepwise reopening. The plan included precautionary measures of infection control and a preparedness plan (<xref rid="t2-cep-2020-01473" ref-type="table">Table 2</xref>). Local class or school closures were allowed based on local infection rates in conjunction with in-school health and safety measures, while students continued distance learning at home. Between May 1 and July 12, 2020, a total of 127 school-aged pediatric COVID-19 cases were confirmed in Korea when schools opened for in-person (face-to-face) classes on May 20. Among them, only 2% (n&#x0003d;3) were exposed to SARS-CoV-2 in the public education system.8) This finding is in line with reports from Norway and Ireland that, in the setting of vigilant infection control and prevention planned in schools, COVID-19 transmission in schools can be limited &#x0005b;<xref ref-type="bibr" rid="b9-cep-2020-01473">9</xref>,<xref ref-type="bibr" rid="b10-cep-2020-01473">10</xref>&#x0005d;. These findings from Korea suggest that the reopening of schools following standardized measures applied to schools such as detailed guidance for school closure, disinfection, and contact management did not aggravate the course of COVID-19 resurgence in children.</p>
<p>Mobilizing sufficient financing remains a major challenge in implementing the 2030 Agenda for Sustainable Development and achieving the Sustainable Development Goals. Horizontal cooperation&#x02014;the exchange of knowledge, expertise, and technology&#x02014;remodels the development finance landscape. As a signatory to the UN General Assembly Resolution on Buenos Aires outcome document of the second High-level United Nations Conference on South-South Cooperation, the Korean government is keen to champion international development cooperation by sharing its experience, lessons learned, good practices, knowledge, and expertise with other countries through horizontal cooperation. While Korea&#x02019;s traditional forms of international development cooperation (grants, loans, and trade) remain relevant and growing, new complementary approaches such as horizontal cooperation through United Nations Children&#x00027;s Fund (UNICEF)&#x02019;s offices in over 190 countries and territories will help end its dependence on long-established financial mechanisms. We are now happy to include specific Korean examples and lessons learned in mitigating COVID-19 in Korea&#x02019;s contributions.</p>
</body>
<back>
<fn-group>
<fn fn-type="conflict"><p>No potential conflict of interest relevant to this article was reported.</p></fn>
</fn-group>
<ack><p>We thank staff members of UNICEF Seoul Office for their support and contribution in preparation of this manuscript.</p></ack>
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<sec sec-type="display-objects">
<title>Tables</title>

<table-wrap id="t1-cep-2020-01473" position="float">
<label>Table 1.</label>
<caption><p>Key components of national immunization program of Republic of Korea</p></caption>
<table rules="groups" frame="hsides">
<tbody><tr>
<td valign="top" align="left">Key components of national immunization program</td>
</tr>
<tr>
<td valign="top" align="left">Support the vaccine &amp; vaccination expenses</td>
</tr>
<tr>
<td valign="top" align="left">Expansion of vaccine accessibility</td>
</tr>
<tr>
<td valign="top" align="left">School entry requirement of certification</td>
</tr>
<tr>
<td valign="top" align="left">Measles Elimination Program</td>
</tr>
<tr>
<td valign="top" align="left">Hepatitis B Perinatal Transmission Prevention Program</td>
</tr>
<tr>
<td valign="top" align="left">Adverse Event Following Immunization Management System</td>
</tr>
<tr>
<td valign="top" align="left">Electronic Immunization Registry</td>
</tr>
</tbody></table>
</table-wrap>
<table-wrap id="t2-cep-2020-01473" position="float">
<label>Table 2.</label>
<caption><p>COVID-19 prevention guidelines for kindergartens, elementary, middle, and high schools, Republic of Korea</p></caption>
<table rules="groups" frame="hsides">
<tbody><tr>
<td valign="top" align="left" colspan="2">General guideline</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="7">&#x02003;</td>
<td valign="top" align="left">Direction for COVID-19 response measures</td>
</tr>
<tr>
<td valign="top" align="left">Management system and cooperation with partner agencies</td>
</tr>
<tr>
<td valign="top" align="left">Measures to infection control within schools</td>
</tr>
<tr>
<td valign="top" align="left">General response measures: before school hours, going to school, during school hours, during lunch break</td>
</tr>
<tr>
<td valign="top" align="left">Response measures in case of suspected cases</td>
</tr>
<tr>
<td valign="top" align="left">Response measures in case of confirmed cases</td>
</tr>
<tr>
<td valign="top" align="left">Management of dormitories and other facilities</td>
</tr>
<tr>
<td valign="top" align="left" colspan="2">Specific workflow</td>
</tr>
<tr>
<td valign="top" align="left" rowspan="16"></td>
<td valign="top" align="left">Check list for prevention and management of COVID-19</td>
</tr>
<tr>
<td valign="top" align="left">Guidelines for monitoring fever at school</td>
</tr>
<tr>
<td valign="top" align="left">Correct methods for temperature checks</td>
</tr>
<tr>
<td valign="top" align="left">Guidelines for disinfection at school</td>
</tr>
<tr>
<td valign="top" align="left">Guidelines for using masks</td>
</tr>
<tr>
<td valign="top" align="left">Guidelines for the use of air conditioners</td>
</tr>
<tr>
<td valign="top" align="left">Restriction of school facilities in case of confirmed cases at school</td>
</tr>
<tr>
<td valign="top" align="left">Guidelines for students and parents</td>
</tr>
<tr>
<td valign="top" align="left">Psychological support for students after school</td>
</tr>
<tr>
<td valign="top" align="left">Mental health support for students in self-isolation</td>
</tr>
<tr>
<td valign="top" align="left">Guidelines for prevention of infectious diseases</td>
</tr>
<tr>
<td valign="top" align="left">Code of conduct</td>
</tr>
<tr>
<td valign="top" align="left">School rules</td>
</tr>
<tr>
<td valign="top" align="left">Quarantine measures at kindergartens</td>
</tr>
<tr>
<td valign="top" align="left">Code of conduct for people in self-isolation</td>
</tr>
<tr>
<td valign="top" align="left">Code of conduct for people subject to self-isolation</td>
</tr>
</tbody></table>
<table-wrap-foot>
<fn><p>OVID-19, coronavirus disease 2019.</p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
</back></article>