| Comparison Between 24-hour Integrated Growth Hormone Concentrations and Pharmacological Provocation Tests in Children with Short Statue |
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Mi Jung Park1, Duk Hi Kim1, Ho Seong Kim2 |
1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
2Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea |
| 왜소증 환아에서 24시간 성장호르몬 농도와 약물 유발검사에 의한 성장호르몬 반응의 비교 |
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박미정1, 김덕희1, 김호성2 |
1연세대학교 의과대학 소아과학교실
2이화여자대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: The ability to respond to pharmacologial provovation tests may not necessary reflect actuaol secretory patterns of growth hormone. Therefore, the aim of this study in to evaluate the 24-h IC-GH and compare this with their resposnses to standard pharmacological provocation tests for growth hormone comcentrations and to evaluate peak frequency and peak amplitude during 24-h IC-GH in children with short stature.
Methods
: We evaluated 22 cases. Pharmacological growth hormone provocation tests were done with L-dopa (0.5g/1.73㎡) and regular insulin (0.1I/kg). Fourteen were growth hormone deficiency, three were idiopathic short starue, five were normal vontrola. The 24-h IC-GH was sampled every 30minutes using the continuous blood witdrawal pump.
Results
: 1) Twenty-four hour IC-GH were significantly different among 3 groups. Normal contrel group had mean IC-GH value of 5.8±1.1ng/ml, growth hormone dificiency group had 0.8±0.7ng/ml, idiopathic short stature group had 3.6±0.4ng/ml.
2) Significant correlation was found between pharmacological peak GH concentrations and mean 24-h IC-GH.
3) In cases of idiopathic short stature, pharmacological peak GH, were normal, but 24-h peak frequencies and amplitudes were lower compared to normal control.
Conclusion
: In cases of patients with subnormal growth hormone concentrations on provocation tests, measuring 24-h IC-GH is not needed, but in case of normal or subnormal growth hormone concentrations on provocation tests and with subnormal yearly growth rates, it is recommended to measeue 24-h IC-GH. |
| Key Words:
Comparison, 24h-ICGH, Pharmacological Provocation Tests, Short Statue. |
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