Warning: fopen(/home/virtual/pediatrics/journal/upload/ip_log/ip_log_2024-05.txt) [function.fopen]: failed to open stream: Permission denied in /home/virtual/pediatrics/journal/ip_info/view_data.php on line 82

Warning: fwrite(): supplied argument is not a valid stream resource in /home/virtual/pediatrics/journal/ip_info/view_data.php on line 83
A Case of Castleman's Disease in Childhood

Journal of the Korean Pediatric Society 1996;39(2):291-295.
Published online February 15, 1996.
A Case of Castleman's Disease in Childhood
Jong Yoo Lee1, Kyung Bae Park1, Joon Soo Park1, Sang Chul Park1, Sang Man Shin1, Sang Jhoo Lee1, Young Moo Kyu2, Ui Han Kim3
1Department of Pediatrics, College of Medicine, Soon Chun Hyang University, Chunan, Korea
2Department of General, College of Medicine, Soon Chun Hyang University, Chunan, Korea
3Department of Pathology, College of Medicine, Soon Chun Hyang University, Chunan, Korea
소아에서 경부에 발생한 맥관 여포형 림프절증식증(Castleman’s Disease) 1례
이종유1, 박경배1, 박준수1, 박상철1, 신상만1, 이상주1, 구영무2, 김의한3
1순천향대학교 의과대학 소아과학교실
2순천향대학교 의과대학 일반외과학교실
3순천향대학교 의과대학 병리학교실
Castleman's disease(CD) is rare in childhood. It is defined as a localized nodal hyperplasia in mediastinum or cervical area. It is also called angiofollicular lymph node hyperplasia, lymph nodal hamartoma, giant lymph node hyperplasia. It was first described in 1956 by Castleman et al. as a lesion of mediastinal mass. The etiology of CD is not clear. The histologic classification of CD is hyaline vascular and plasma cell type. The hyaline-vascular type is more frequent, and characterized by small hyaline-folliclees and interfollicular capillary proliferation. The plasme cell type is characterized by the large follicles with intervening sheets of plasma cells. The clinical classification of CD is solitary and multicentric type. The solitary type is usually asymptomatic but, the multicentric type is usually combined systemic manifestations, such as fever, anemia, hyperglobulinemia. Complete surgical resection of involved lymph nodes is both diagnostic and therapeutic. The prognosis of solitary type is good, in a general way. We experienced CD cases in five-year-old girl, who had a 4¡¿3 cm solid mass in postrior triangle of neck, right. The mass was removed completely and confirmed Castleman's disease microscopically. The histopathologic finding was a proliferation of germinal centers with hyaline thickening of the wall and the interfollicular stroma showed hyperplastic vessels admixed with lymphocytes, plasma cells and eosinophils. She discharged after six days of operation and her prognosis was good.
Key Words: Castleman's disease, Neck, Childhood

METRICS Graph View
  • 2,425 View
  • 9 Download