Journal of the Korean Pediatric Society 1996;39(5):732-737.
Published online May 15, 1996.
A Case of Chronic Recurrent Multifocal Osteomyelitis
Weon Young Lee, Eell Ryoo, Mi Jin Jeong, Kye Hwan Seol, Kil Hyen Kim, Hak Su Lee, ,
Department of Pediatrics, Chungang Gil Hospital, Inchon, Korea
만성 재발성 다발성 골수염 1례
이원영, 류일, 정미진, 설계환, 김길현, 이학수, 이영석, 박성혜
중앙 길병원 소아과
Chronic recurrent multifocal osteomyelitis(CRMO) is an unusual inflammatory process involving multiple osseous sites. No causative agent can be consistently isolated from these lesions despite multiple biopsies and the affected child purses a clinical course of chronic remissions and exacerbations independent of antibiotic therapy. Biopsy of the lesions did not reveal any pathogens. Immunologic investigation revealed no abnormality common to the patient and there was no indication of agenetic etiology. The natural history of chronic recurrent multifocal osteomyelitis appears to be slow, spontaneous resolution of the osseous lesions without specific treatment. We experienced a case of CRMO in an 11-year-old girl who had complained of fever, pain on knee and wrist joints for several weeks. We studied the clinical, radiographic, histological findings in this patient and we report a case of CRMO with brief review of related literature.
Key Words: Osteomyelitis, Multifocal lesions, Chronic recurrent disease

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