Warning: fopen(/home/virtual/pediatrics/journal/upload/ip_log/ip_log_2024-03.txt) [function.fopen]: failed to open stream: Permission denied in /home/virtual/pediatrics/journal/ip_info/view_data.php on line 82

Warning: fwrite(): supplied argument is not a valid stream resource in /home/virtual/pediatrics/journal/ip_info/view_data.php on line 83
Comparison between adverse effects of low and usual doses of intravenous aminophylline

Korean Journal of Pediatrics 2009;52(4):441-445.
Published online April 15, 2009.
Comparison between adverse effects of low and usual doses of intravenous aminophylline
Bok Ki Kim, Dae Hyun Lim, So Hyun Ahn, Jong Hoon Kwa, Jeong Hee Kim, Byong Kwan Son
Department of Pediatrics, School of Medicine, Inha University, Inchon, Korea
정주 아미노필린의 투여 농도에 따른 부작용에 관한 연구
김복기, 임대현, 안소현, 곽종훈, 김정희, 손병관
인하대학교 의과대학 소아과학교실
Correspondence: 
Dae Hyun Lim, Email: dhyunlim@inha.ac.kr
Abstract
Purpose
: Some patients develop side effects from theophylline even at low serum concentrations. We designed a prospective study to evaluate the side effects of theophylline.
Methods
: A Prospective, controlled trial study was conducted. The low-dose group received an intravenous continuous aminophylline dose of 5 mg/kg/day on the first day and subsequently 10 mg/kg/day on the following two days. The usual-dose group received 10 mg/kg/day for three days and the control group received normal saline for three days. Heart rate, respiratory rate, serum concentration of theophylline, and four adverse events (irritability, sleep disturbance, jitter, and vomiting) were checked at the time of admission and at 2, 12, 24, 48, and 72 h after the start of aminophylline infusions.
Results
: Nine patients out of 37 in the low-dose group and six of 21 in the usual-dose group dropped out because of uncontrolled irritability. The serum concentrations of theophylline in dropouts (3.68¡¾1.93 ìg/mL) and participants (4.47¡¾2.45 ìg/mL) were not significantly different. Irritability was a more frequent side effect in the usual-dose group at 12 h, but there was no difference between the low-dose and usual-dose groups in terms of vomiting, sleep disturbance, and jitter. Most of the severe adverse effects were observed in children below two years of age.
Conclusion
: Some patients dropped out regardless of the initiating aminophylline dose, especially patients under the age of two years.
Key Words: Aminophylline, Asthma


METRICS Graph View
  • 2,322 View
  • 78 Download