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Cyclophosphamide-Induced Hemorrhagic Cystitis in Acute Lymphocytic Leukemia and Non-Hodgkin Lymphoma.

Journal of the Korean Pediatric Society 1989;32(5):665-669.
Published online May 31, 1989.
Cyclophosphamide-Induced Hemorrhagic Cystitis in Acute Lymphocytic Leukemia and Non-Hodgkin Lymphoma.
Young Seo Park, Il Soo Ha, Soon Ki Kim, Hae Il Jung, Yong Choi, Hyo Seop Ahn
Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
급성 림프구성 백혈병 및 악성 림프종에서 Cycolophosphamide에 의한출혈성 방광염에 관한고찰
박영서, 하일수, 김순기, 정해일, 최용, 안효섭
서울대학교 의과대학 소아과학교실
Received: 26 October 1988   • Accepted: 26 October 1988
Abstract
We studied the cyclophosphamide-induced hemorrhagic cystitis in 72 cases of acute lymphocytic leukemia or Non-Hodgkin lymphoma, which had been treated at Seoul National University Children' s Hospital from June, 1985 to May, 1988 1) Among 72 cases treated with cyclophosphamide, 6 cases(12.8%) developed hemorrhagic cystitis in 47 cases of acute lymphocytic leukemia and 2 cases(8.0%) in 25 cases of Non-Hodgkin lymphoma. 2) The development of hemorrhagic cystitis was not related to the dose of cyclophosphamide or the hydration during therapy but the symptoms were mild in the cases hydrated during therapy. 3) The hemorragic cystitis developed within 30 days after therapy except 1 case, and developed after first or second administration of cyclophosphamide. Therefore the risk of hemorrhagic cystitis seems to be high in early period of therapy. 4) The all cases of hemorrhagic cystitis were improved without complications or sequalae and the recurrence was absent in all cases after readministration of cyclophosphamide. But it will be necessary to follow up for long time.
Key Words: Cyclophosphamide, Hemorrhagic cystitis, Acute lymphocytic leukemia, Non-Hodgkin Lymphoma


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