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Clinical Study of Plasma A.V.P Levels in Children with Meningitis.

Journal of the Korean Pediatric Society 1985;28(4):325-329.
Published online April 30, 1985.
Clinical Study of Plasma A.V.P Levels in Children with Meningitis.
Jun Gun Kim, Hye Kyung Cho, Mea Young Chung, Dong Hyuck Kum
Department of Pediatrics,Korea General Hospital, Seoul,Korea
하절기 뇌막염환자에 있어서 혈장 A.V.P.치에 관한 연구
김준근, 조혜경, 정미영, 금동혁
고려병원 소아과
Plasma A.V.P. levels were determined by radioimmunoassay in 31 children who were hospitalized to Pediatric Department of the Korea General Hospital from June 1984 to August 1984. Among 31 hospitalized children, 21 were meningitis cases as for study group and the rest 10 were URI cases as for control group. Meningitis cases were classified as aseptic meningitis group(16 aseptic meningitis cases) and bacterial meningitis group(2 tuberculous meningitis, 1 meningococcal meningitis and 2 partially treated bacterial meningitis cases). These groups were statistically matched and the results were as follows: 1)Plasma A.V.P. levels in bacterial meningitis group(69.0±22.0 pg/ml) were significantly elevated to compare with that of control group(4.90±3.43 pg/ml).: p<0.005. 2)Plasma A.V.P. levels in aseptic meningitis group(3.43±2.23 pg/ml) were normal and were no significant difference to compare with that of control group. 3)Bacterial meningitis group revealed hyponatremia but aseptic meningitis group revealed normal serum sodium concentration. 4)An A.V.P./Na(serum sodium) ratio was calculated. Bacterial meningitis group had a significantly greater A.V.P./Na ratio than other two groups: p<0.001. 5)Among 21 meningitis cases, SIADH were developed in 5 cases of bacterial meningitis group but SIADH were not developed in all 16 cases of aseptic meningitis group. Considering above results, there is not necessary to treat SIADH in aseptic meningitis patient.
Key Words: Plasma A.V.P., SIADH, Meningitis

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