Scabies mimicking graft versus host disease in a hematopoietic cell transplant recipient

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Korean J Pediatr. 2018;61(11):371-373

Publication date (electronic) : 2018 November 9

doi : https://doi.org/10.3345/kjp.2018.07199

Dongsub Kim, MD¹, Soo-Han Choi, MD², Dong Youn Lee, MD, PhD³, Juyoun Kim, MS⁴, Eunjoo Cho, MS⁴, Keon Hee Yoo, MD, PhD¹, Hong Hoe Koo, MD, PhD¹, Yae-Jean Kim, MD, PhD^,1

¹Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

²Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwasung, Korea

³Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

⁴Department of Pediatrics, Samsung Medical Center, Seoul, Korea

Corresponding author: Yae-Jean Kim, MD, PhD Division of Infectious Diseases and Immunodeficiency, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea Tel: +82-2-3410-0987 Fax: +82-2-3410-0043 E-mail: yaejeankim@skku.edu

Received 2018 October 24; Revised 2018 November 7; Accepted 2018 November 9.

Abstract

Introduction

Scabies is a contagious skin infestation caused by Sarcoptes scabiei var. hominis [1]. The estimated prevalence of human scabies is about 300 million cases yearly in the world. Scabies occurs at all ages and at various socioeconomic levels [2]. Epidemics have been liked to poverty, poor water supply, poor sanitation, and overcrowding. Scabies generally causes intense itching sense and secondary bacterial infection can occur. There are also some reports of scabies outbreak in hospitals and nursing homes [3-5].

We describe the first Korean case of scabies in an allogeneic hematopoietic cell transplant (HCT) recipient. The patient developed severe pruritus after engraftment, and graft versus host disease (GVHD) was suspected.

The Institutional Review Board (IRB) at Samsung Medical Center, Seoul, South Korea reviewed and approved this study (approval number: 2018-10-112). Informed conset was exempted by IRB.

Case report

A 13-year-old male patient with T-cell acute lymphocytic leukemia underwent a sibling matched allogeneic HCT in February of 2010. As for conditioning regimen, he received total body irradiation, cytarabine, and cyclophosphamide. Neutrophil engraftment was achieved on posttransplant day 10. His pretransplant varicella zoster virus immunoglobulin (Ig) G was positive and he was on acyclovir prophylaxis and cyclosporine was given for GVHD prophylaxis.

On posttransplant day 12, he developed erythematous papular rash on face and trunk with pruritus. His white blood cell count was 16,670/μL (neutrophil 75%, lymphocyte 6%, eosinophil 0%). Grade 1 skin graft versus host disease (GVHD) was suspected. Until posttransplant day 21, skin lesions persisted and partial crusted lesions were observed (Fig. 1). He received multiple antihistamine agents and topical steroid but complained of severe itching sensation.

Fig. 1.

Erythematous papular rash with partial crusted lesions.

On posttransplant day 28, skin biopsy was performed after a consultation with dermatologists. Skin punch biopsy showed perivascular chronic inflammatory cell infiltration and cytoid body of basal layer (Fig. 2). Conservative treatment for pruritus and management for GVHD was recommended. Systemic corticosteroid, gabapentin, and lorazepam were added.

Fig. 2.

Perivascular chronic inflammatory cell infiltration and focal liquefaction degeneration of the basal layer with cytoid body (H&E, ×40).

On posttransplant day 42, a consultation was requested to the pediatric infectious diseases physicians for the evaluation of persistent intense itching sensation and any possible skin infection. When the infectious diseases team visited the patient and questioned, his mother and grandmother reported that they also developed papular rash with itching sensation. An urgent request for an additional evaluation was requested to a dermatologist. A contagious skin infection was suspected and direct smear from his finger web revealed numerous mites (Fig. 3). He was diagnosed with classic scabies and immediately discharged from the hospital because he was otherwise stable except the skin lesions. Crotamiton ointment was applied for treatment at home. Currently, crotamiton is not recommended by U.S. Food and Drug Administration with safety concerns.

Fig. 3.

Direct smear from hand web spaces revealing mites (white arrow).

After a week, pruritus subsided and skin lesions continued to improve during the 6 weeks of outpatient clinic follow-up visits.

An investigation was performed in all potentially exposed individuals in the hospital. Infection control intervention and environmental disinfection were also performed to prevent the institutional outbreak. There were no other scabies cases from this nosocomial exposure.

Discussion

This is the first Korean case of scabies in a 13-year-old acute leukemia patient who underwent HCT. The patient developed symptoms after the engraftment of hematopoietic stem cells and acute GVHD was mostly suspected. Scabies was diagnosed with additional history taking of family members after 30 days of symptom onset.

With improved sanitation, clinicians are unfamiliar with scabies. Scabies can be misdiagnosed as seborrheic dermatitis, eczematous dermatitis, impetigo, arthropod bites, and Langerhans cell histiocytosis [6]. In our case, patient’s clinical situation involving allogeneic HCT made us suspect GVHD with high priority. The number of HCT is increasing and there are various situations during the posttransplant period. Therefore, unusual infectious pathogens should be considered in patients with atypical skin conditions [7].

There are many studies about pathogenesis of scabies explaining complex innate, humoral, and cellular responses in human. Predominant CD8+ T cell infiltration and absence of B cells were demonstrated in skin lesions of crusted scabies indicating cellular immunity contribute to the inflammation [8]. Skin rash and itching sensation with scabies are associated with type I (immediate) and type IV (delayed) hypersensitivity [9]. In a prospective Australian study, serum IgE level was markedly elevated in 96% of scabies patients [10]. There are little data on immune response in a HCT setting. In our patient, he developed symptoms after the engraftment which represents beginning of immune recovery and also a usual period of acute GVHD development.

Previous reports of scabies among HCT recipients who developed symptoms within 100 days are described (Table 1). There were three pediatric patients including one in this report. All the pediatric patients underwent allogeneic HCT. Two children underwent skin biopsy and were initially diagnosed with skin GVHD. In all pediatric cases, it took more than 2 weeks to diagnose scabies.

Table 1.

Reports of scabies infestation in stem cell transplant recipient

In conclusion, although not common, clinicians should consider scabies as a possible condition in patients with unusual intense pruritus and additional itching persons in close contacts even in HCT recipients.

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