Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis

Article information

Clin Exp Pediatr. 2022;65(3):152-152

Publication date (electronic) : 2022 February 17

doi : https://doi.org/10.3345/cep.2021.01298.r1

¹Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran

²Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran

Corresponding author: Mahnaz Seifi Alan Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran Email: m_seifi2012@yahoo.com

Received 2021 August 22; Accepted 2021 October 28.

See the letter "Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis" on page 152.

See the Original "Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis" in Volume 65 on page 85.

To the editor: We read with great interest a meta-analysis by Maleki et al. [1] on the association between prenatal excess of androgen exposure in the offspring of mothers with polycystic ovary syndrome (PCOS) and risk of attention-deficit/hyperactivity disorder (ADHD) in them. They found that maternal PCOS increases the offspring risk of ADHD. However, we have to point out a deficiency of this study, we noted that 1 of 6 articles that were included in this study did not meet the eligibility criteria as it’s object was different [2]. Hergüner et al. [2] aimed to compare ADHD symptoms between women with PCOS and controls. This deficiency may introduce bias and lead to a false conclusion.

Notes

Conflicts of interest

No potential conflict of interest relevant to this article was reported.

Funding

This letter received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

References

1. Maleki A, Bashirian S, Soltanian AZ, Jenabi E, Farhadinasab A. Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis. Clin Exper Pediatr 2021;37:716–20.

2. Hergüner S, Harmancı H, Toy H. Attention deficit-hyperactivity disorder symptoms in women with polycystic ovary syndrome. Int J Psychiatry Med 2015;50:317–25.

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