All issues > Volume 35(1); 1992

Original Article

J Korean Pediatr Soc. 1992;35(1):34-43. Published online January 15, 1992.

A Scientific Analysis of Changes in Hemostatic Parameters Following Cardiopulmonary

Hyoung Won HW Lee¹, You In YI Park¹, Kwang Chul KC Lee¹, Ju Won JW Lee¹, Soon Kyum SK Kim¹

¹Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea

Abstract

Despite the scientific advances made in medical science, the potential for serious hemorrhagic complications remain an important problem in patients undergoing open heart surgery with extracorporeal circultation (OHSEC). Hematologic abnormalities that have been reported in association with OHSEC and that may lead to a hemorrhagic tendency include thrombocytopenia, alteration of coagulation factors, advanced fibrinolysis and inadequate neutralization of heparin. We investigated the changes in hemostatic parameters including platelet count (MPC), mean platelet volume (MPV), bleeding time (BT), prothrombin time (PT) and activated partial thromboplastin time (aPTT) in patients who underwent OHSEC. The results are summarized in the table shown below: Although there were several statistically significant changes observed in creatain parameters such as MPC, MPV, BT and aPTT, no clincially apparent hemorrgagic complications were observed.

Keywords :Cardiopulmonary bypass, Hemostatic parameter