All issues > Volume 35(3); 1992

Original Article

J Korean Pediatr Soc. 1992;35(3):364-370. Published online March 15, 1992.

The Effect of Prostaglandin E1 Infusion for Palliation of Ductus Dependent Cyanotic Congenital Heart Disease in Neonates

Ji Hee JH Park¹, Chang Sung CS Son¹, Joo Won JW Lee¹, Young Chang YC Tockgo¹

¹Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea

Abstract

Prostaglandin E1 (PGE1) was administered to 12 neonates with cyanotic congenital heart disease in whom pulmonary or systemic blood flow were entirely or significantly dependent on persistent patency of the ductus arteriosus. 10 neonates responded favorably to PGE1, by showing significant increase of PaO2 after PGE1 infusion but remaining 2 neonates with hypoplastic left heart syndrome failed to respond. The mean age of the latter was more than 10 days. 8 case with right ventricular outflow obstructions showed significant increment of PaO2 after PGE1 infusion whereas 3 case of left outflow obstruction did not. 3 cases with preinfusion PaO2 less than 20 mmHg showed greater increase of PaO2 than remaing 9 cases with preinfusion PaO2 more than 20mmHg. In relation to preinfusion PaO2 level, there was no significant differences in postinfusion increment of PaO2. 7 cases with the mean age of less than 10 days showed significant increase of PaO2 after PGE1 infusion whereas 5 cases with the mean age of more than 10 days did not. In conclusion, PGE1 infusion is an effective and safe method to improve pulmonary blood flow or systemic blood flow in infants with congenital heart disease who depend on the ductus arteriosus to supply part or all of pulmonary or systemic blood flow.

Keywords :Prostaglandin E1, Ductus arteriosus