All issues > Volume 35(4); 1992

Case Report

J Korean Pediatr Soc. 1992;35(4):545-550. Published online April 15, 1992.

An Autopsy Case of Infant of Diabetic Mother with d-Transposition of Great Arteries and Hypertrophic Cardiomyopathy

Kye Hwan KH Seol¹, Eui Kyeung EK Jung¹, Chang Sung CS Son¹, Joo Won JW Lee¹, Soon Kyum SK Kim¹

¹Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea

Abstract

Generally, infants of diabetic mother(IDM) have various diseases and complications affecting multisystems resulting in high perinatal morbidity and mortality. It is well known that IDM have especially higher incidence of congenital anomalies including congenital heart disease(CH D). dTransposition of great arteries(d-TGA), ventricular septal defect and hypertrophic cardiomyopathy(HCM) form most of CHD occurring in IDM. Of these, HCM appears as a benign, transient and nonfamilial cardiomyopathy in early neonatal period with the natural history of a spontaneous resolution of symptoms and septal hypertrophy. Most of IDM with HCM need only supportive care, whereas those with d-TGA show high mortality despite of intensive care. Recently the authors experienced 1 case of a female newborn with congenital heart disease who was delivered to a diabetic woman by cesarean section with birth weight 4800gm and expired 12 hours after birth. So we report this case of IDM accompanying hypertrophic cardiomyopathy and d-TGA which were confirmed on autopsy, with a brief review of literatures.

Keywords :Infants of diabetic mother, Hypertrophic cardiomyopathy, d-TGA