All issues > Volume 35(5); 1992

Original Article

J Korean Pediatr Soc. 1992;35(5):646-651. Published online May 15, 1992.

Inciedence of Sepsis Associated with Total Parenteral Nutrition Solutions Made in the Nursery and Pharmacy

Moon Chan MC Kim¹, Jin Won JW Park¹, Yun Joo YJ Chung¹

¹Department of Pediatrics, Kosin College of Medicine, Pusan, Korea

Abstract

From 1985 to 1987, when Total Parenteral Nutrition (TPN) solutions was made in the nursery without laminar flow hood and other usual aseptic techniques (method 1), there was sepsis in 27% out of 33. From 1988 to 1990, to prevent high incidence of sepsis, TPN was made in the pharmacy under laminar flow hood and by pharmacist who wore scrub suit and gloves (method 2). We compared the rate of sepsis in method 1 and 2. 1) There was sepsis in 9 patients (27%) out of 33 in method 1 and in 3 patients(8%) out of 36 in method 2. The incidence of sepsis was reduced but was not significant statistically. 2) Staphylococcus epidermidis was the most common causative organism of sepsis, in 5 patients (13%) out of 39(method 1 and 2). 3) There was sepsis caused by Candida albicans in one case treated with TPN for 20 days. 4) We speculate that more scrutinized supervision of aseptic techniques on making TPN solution and skin care as well as tubing cares are needed to reduce the high incidence of sepsis.

Keywords :Total Parenteral Nutrition, Sepsis