All issues > Volume 35(6); 1992

Case Report

J Korean Pediatr Soc. 1992;35(6):804-808. Published online June 15, 1992.

A Case of Neonatal Hypothyroidism due to Maternal TSH-Binding Inhibitor Immunoglobulin

Myung Lye ML Kim¹, Rhie R Choi¹, Dong Hwan DH Lee¹, Sang Jhoo SJ Lee¹

¹Department of Pediatrics, College of Medicine, Soonchunhyang University, Seoul, Korea

Abstract

Neonatal screening for congenital hypothroidism is important because of the possibility that mental retardation may be avoided if treatment started early. A 1 day old patient was admitted to our department of Pediatrics for congenital hypothyroidism screening. The mother was 33 years old and had been on thyroid replacement therapy since 32 years of age. During the pregnancy she was euthyroid and had 83.4% of TSH-binding inhibitor immunoglobulin. The hypothyroidism was characterized by low T4 levels(3.04 ㎍/dl), elevated TSH(50μU/ml) and delayed bone age. At 3 days of age, the baby was started on thyroxine treatment. Thyroxine substitution was withdrawn for 1 week at 26 months of age, laboratory signs of hypothyroidism reappeared. On the thyroid scan, it was decreased uptake function of both thyroid glands. So thyroxine has been readministering till now and the patient is under close observation.

Keywords :Hypothyroidism, TBII