All issues > Volume 35(7); 1992

Original Article

J Korean Pediatr Soc. 1992;35(7):909-920. Published online July 15, 1992.

A Clinical Aspect of the Hemolytic Uremic Syndrome

Hye Won HW Park¹, Tae Sun TS Ha¹, Il Soo IS Ha¹, Hae Il HI Cheong¹, Yong Y Choi¹, Kwang Wook KW Ko¹

¹Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea

Abstract

We reviewed the medical records of 14 children (8 girls, 6 boys), diagnosed as hemolytic uremic syndrome at Seoul National University Children뭩 Hospital from 1981 to 1990. The age at presentation ranged from 1 month to 10 years, with a mean age of 2.7 years. Only eight (57.1%) of the children had diarrheal prodrome and five (35.7%) had grossly bloody stool. Oligoanuria developed in eight (57.1%) and gross hematuria in eight (57.1%). Six (42.9%) chlidren had seizures and alteration of consciousness occurred in five (35.7%). In six children (42.9%) serum uric acid levels greater than 15mg/dl were observed. Hypocomplementemia was noted in six (60.0%) of the ten children who had been measured. No organism grew in stool culture for Salmonella and Shigella from 5 diarrheal children. Overall outcome was poor. Of the 14 children, only five (35.7%) recovered their renal function completely. Hypertension with proteinuria or microscopic hematuria persisted after recovery from renal failure in three (21.4%). Four (28.6%) progressed to end-stage renal disease requiring dialysis and one (7.1%) slowly developed renal insufficiency. One (7.1%) died of acute renal failure.

Keywords :Hemolytic uremic syndrome