All issues > Volume 35(7); 1992

Case Report

J Korean Pediatr Soc. 1992;35(7):984-988. Published online July 15, 1992.

A Case of Pseudohypoaldosteronism

Yong Soon YS Kwon¹, Hyo Gyoung HG Shin¹, Mi Soo MS Ahn¹, Hong Bae HB Kim¹

¹Department of Pediatrics, Wallace Memorial Baptist Hospital, Pusan, Korea

Abstract

Pseudohypoaldosteronism(PHA) is rare salt losing disease which is characterized by mineralcorticoid unresponsiveness of the end organ. Severe hyponatremia and hyperkalemia are present despite high plasma aldosterone. We experienced a case of PHA in a 40-days old male infant who was presented with anorexia, vomiting and lethargy for several days. Labortory data showed hyponatremia, hyperkalemia and metabolic acidosis. Renal function was normal except initial transient elevation of BUN and creatinine, normalized after correction of dehydration. Adrenal function was normal. Plasma renin activity and plasma aldosterone concentration were markedly elevated. Under the impression of pseudohypoaldosteronism, we tried oral NaCl supplementation. Thereafter the clinical state of the patients was improved. We report a case of PHA with brief review of related literatures.

Keywords :Pseudohypoaldosteronism, Mineralcorticoid unresponsiveness