All issues > Volume 35(8); 1992

Original Article

J Korean Pediatr Soc. 1992;35(8):1066-1072. Published online August 15, 1992.

The Effects of RU 41.740, a Glycoprotein Extract from Klebsiella pneumoniae, on Peripheral Blood Mononuclear Cells

Moon Kyu MK Kim¹, Dong Soo DS Kim¹, Hyun Ok HO Kim²

¹Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
²Department of Clinical Pathology, Yonsei University, College of Medicine, Seoul, Korea

Abstract

RU 41.740 is extract of Klebsiella pneumoniae K2O1 stain with immunomodulatory properties. It was composed of two glycoproteins, each being 31 KD and 33 KD in their molecular weight, on SDS-PAGE analysis. RU 41.740 was observed to augment cell mediated immunity of human peripheral blood mononulear cells measured by tritiated thymidine uptake method. Maximal augmentation was observed after 72 hours of incubation. This effect on cellular immunity was suppressed by the antibodies which was producted by injecting RU 41.740 intradermally to the rabbit. Treatment of peripheral blood mononuclear cells with RU 41.740 did not change NK cell activity using K 562 cell as a target cell.

Keywords :RU 41.740, Cell mediated immunity