All issues > Volume 35(9); 1992

Original Article

J Korean Pediatr Soc. 1992;35(9):1236-1242. Published online September 15, 1992.

Children with Delayed Speech Development

Sang Kee SK Park¹, Ho Sung HS Yoo¹, Yeong Bong YB Park¹

¹Department of Pediatrics, Collefge of Medicine, Chosun University, KwangJu Korea

Abstract

The antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase and the lipid peroxidation were assayed in erythroctyes from the cord blood of 25 fullterm newborn infants and their maternal blood abtained immediatedly after normal delivery. Superoxide dismutase and catalase activites in cor blood erythroctytes were significantly lower when compared with their mothers, but glutathione peroxidase activities were not significantly lower. The levels of malondialdehyde were significantly higher in cord blood than in the maternal blood. The methemoglobin productio and hemolysis induced by ferric chloride or xanthine+xanthine oxidase or 100% oxygen were increased significantly in cord blood. The glutathinone s-transferase activietes were significantly increased in cord blood when comapared with maternal blood. These results suggest that erythrocytes of newborn infants may be more susceptibel to oxydative injury because of low levels of natioxicant enzymes in cord blood, which may play a role in the development of neonatal hemolysis and jaundice.

Keywords :Superoxide dismutase, Catalase, Glutathione peroxidase, Erythrocyte, Newborn infant