All issues > Volume 35(9); 1992

Case Report

J Korean Pediatr Soc. 1992;35(9):1272-1279. Published online September 15, 1992.

Acquired Persistent Cytomegalovirus Infection : An Association with Common Variable Immunodeficiency

Min Hyea MH Kim¹, Young Mi YM Hong¹, Sung Joo SJ Lee¹, Je Geun JG Chi², Dong Soo DS Kim³

¹Department of Pediatrics, Ewha Woman`s University College of Medicine, Seoul, Korea
²Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
³Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea

Abstract

Acquired persistent cytomegalovirus infection was diagnosed by anti CMV antibody and lymph node biopsy and persisted in a 3-year-old boy with recurrent episode of high fever, lymphadenopathy hepatosplenomegaly and pneumonia. Initial immunologic abnormalities including low serum IgG, high IgM decreased T4 and T4/T8 ratio finally progressed to immunologic paralysis which was compatible to common variable immunodeficiency. This is the first case which showed an association of acquired persistent cytomegalovirus infection with coimmon variable immunodeficiency. A related literature was reviewd.

Keywords :Persistent CMV infection, Immune disorder, Commom variable immunodeficiency