All issues > Volume 35(10); 1992

Case Report

J Korean Pediatr Soc. 1992;35(10):1443-1448. Published online October 15, 1992.

Effect of Cultured Thymic Epithelium Transplantation in a Patients with Severe Combined Immunodeficiency

Soo Kyung SK Yun¹, Byoung Ho BH Cha¹, Woo Seung WS Jeoun¹, Dong Soo DS Kim¹

¹Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea

Abstract

Severe combined immunodeficiency disease is caused by a group of genetic disease characterized by abnormal function of T and B lymphocytes. The treatment of choice for severe combined immunodeficiency disease is a HLA mached bone marrow transplant, but transplantation of cultured thymus epithelium was used to treat severe combined immunodeficiency disease in case of that mached, related bone marrow donors were not available. We are reporting a case with severe combined immunodeficiency disease who was treated by transplantation of cultured thymic epithelium, which showed temporary increase of peripheral lymphocytes and improvement of clinical pictures.

Keywords :Chltured thymic epitelium transplantation, Severe combined immunodeficiency disease