All issues > Volume 35(11); 1992

Original Article

J Korean Pediatr Soc. 1992;35(11):1509-1513. Published online November 15, 1992.

Hypercalciuria Associated with Nephropathy (diagnosis by renal biopsy)

Hyun Ho HH Shin¹, Jae Yoon JY Kim¹, Chong Woo CW Bae¹, Sung Ho SH Cho¹, Byoung Soo BS Cho¹, Chang Il CI Ahn¹, Young Tae YT Ko², Moon Ho MH Yang³

¹Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea
²Department of Radiology, College of Medicine, Kyung Hee University, Seoul, Korea
³Department of Anatomical Pathology, College of Medicine, Kyung Hee University, Seoul, Korea

Abstract

Idiopathic hypercalciuria is defined as excessive urinary excretion of calcium in normocalcemia without any primary cause. We performed the sono-guided percutaneous renal biopsy for patients of recurrent hematuria, persistent microscopic hematuria, proteinuria and RBC cast to evaluate underlying nephropathy. We could obtained the following results 1) The age at the renal biopsy ranged from 3 years to 14 years. Sex ratio is 1.9:1 (M:F) 2) The treatments of hypercalciuria were hydrochlorothiazide in 13 cases, and supportive management in 7 cases. 3) The results of renal biopsy were IgA nephropathy in 7 cases (35%), mesangium proliferative GN in 6 cases (30%), H-S-P nephritis in 2 cases (10%) and minor glomerular lesion in 5 cases (25%). In conclusion, even thought patients with hematuria show hypercalciuria by Stapleton and Coe et al, renal biopsy is mandatory especially when hypercalciuria associated with persistent or recurrent gross hematuria, massive proteinuria and RBC cast.

Keywords :Idiopathic hypercalciuria, Renal biopsy, Nephropathy