All issues > Volume 36(3); 1993

Case Report

J Korean Pediatr Soc. 1993;36(3):434-438. Published online March 15, 1993.

A Case of Monozygotic Twin with Dwn Syndrome

Seong Heon SH Jeon¹, Choong Hyun CH Yoon¹, Young Wook YW Kim¹, Ki Bok KB Kim¹

¹Department of Pediatrics, Kwangju Christian Hospital, Kwangju, Korea

Abstract

Down syndrome is the most common autosomal chromosomal abnormality characterized by mental and growth retardation, and by various typical features including prominent epicanthal fold, oblique palpebral fissure, flat nasal bridge, short and broad hand, wide toe interspace, etc. The overall incidence has been shown to be 1:800 deliveries, increasing with advancing maternal age. However, twin cses are extremely rare, and thus far only 500 cases were reported worldwide. We have recently observed 10-day-old male monozygotic twins with Down syndorme, born to a mother of 30 years of age with one normal child. Both have VSD confirmed by 2D-echocardiography, in addition to various typical features. Cytoenetic examination revealed that both have karyotypes of 47, XY,+21. This is the first report in Korea as far as the authors are aware of.

Keywords :Down syndrome, Monozygotic twin