All issues > Volume 36(4); 1993

Case Report

J Korean Pediatr Soc. 1993;36(4):589-595. Published online April 15, 1993.

Recurrent Rhinocerebral Mucormycosis - A Case Report

Ho Sung HS Kim¹, Jin Young JY Park¹, Bo Young BY Yun¹, Eun Sil ES Dong¹, Hee Young HY Shin¹, Hoan Jong HJ Lee¹, Hyo Seop HS Ahn¹, Je Geun JG Chi², Myung Whun MW Sung³

¹Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
¹Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
²Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
³Department of Otolayngology, Seoul National University College of Medicine, Seoul, Korea

Abstract

A case of recurrent rhinocerebral mucormycosis that has occurred during an induction chemotherapy for acute megakaryocytic leukemia in a 10 year-old boy is reported. He had suffered from high fever, proptosis, right eye ball pain and necrotic inflammation of hard palate during the chemotherapy of leukemia. CT scan of the paranasal sinus showed inflammatory change of right ethmoid and maxillary sinuses, and right orbital cystic mass which displaced medial rectus muscle. Pathologic examination of the inflammatory mass revealed mucormycosis with characteristic hyphae invading vessel walls. He was managed with 2 times of extensive debridement of necrotic tissue and currettage of cystic mass, and intravenous amphotericin-B for 80 days with apparent improvement. Seven months after discharge from the hospital, necrosis of posterior nasal septum and hard palate was noted for the second time. It was managed again with 2 times of extensive debridement. Since this last operation he is on follow-up for 16 months uneventfully and is on therapy with low dose Ara-C in continuous remission.

Keywords :Rhinocerebral mucormycosis, Recurrent, Acute megakaryocytic leukemia