All issues > Volume 36(5); 1993

Original Article

J Korean Pediatr Soc. 1993;36(5):656-663. Published online May 15, 1993.

The Change of Anti-HBs Titer after Hepatitis B Vaccination in Newborn According to Dosage and Time

Joon Young JY Lee¹, Yong Sik YS MIn¹, Chang hwi Ch Kim¹, Sang Jhoo SJ Lee¹

¹Department of Pediatrics, Soon Chun Hyang University, College of Medicine, Seoul, Korea

Abstract

We studied anti-HBs titer, positive and effective rate in relation to dosages(5, 10) and time interval after third vaccination in 23 infants born to HBsAg negative mother. The babies were divided into two groups. In one group(n=12), 5 of Hepavax was administered intramusculary at 1 month, 2 months and 6 months age, in other group (n=11), 10 of Hepavax at same time interval. And the anti-HBs was studied at 2 months and 3 year after third vaccination by radioimmunoassay. The results were as follows. 1) The anti-HBs positive rate was 100% in two groups at 2 months and 3 years after vaccination. 2) The geometric mean anti-HBs titer at 2 months after third vacciantion was 9418.3±13041.5 IU/L in 5㎍ group and 12750.0±23895.5 IU/L in 10㎍ group, and 3 year after vaccination, 949.4 ±1404.0 IU/L in 5㎍group, 1067.4±1067.7 IU/L in 10㎍group. There were no significant difference between two groups, although mean anti-HBs titer decreased significantly after 3 years. 3) The effective rate at 3 years after vaccination was 66.7% in 5㎍group and 72.8% in 10㎍ group. There was no statistical significant difference between two groups.

Keywords :Hepatitis B vaccine, immunogenecity