All issues > Volume 36(5); 1993

Original Article

J Korean Pediatr Soc. 1993;36(5):680-686. Published online May 15, 1993.

A Clinical Study of Testicular Relapse in Childhood Acute Lymphocytic Leukemia

Hye Ok HO Roh¹, Chuhl Joo CJ Lyu¹, Seung Hwan SH Oh¹, Chang Hyun CH Yang¹, Kir Young KY Kim¹, Byung Soo BS Kim²

¹Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
²Yonsei Cancer Center, College of Medicine, Seoul, Korea

Abstract

From January 1984 to June 1991, we studied testicular relapsed patients among 105 cases of acute lymphocytic leukemia in children who were admitted to the Department of Pediatrics and Yonse Cancer Center, Yonsei University Severance Hospital. The results were as follows: 1) 15 out of 105(14.4%) cases of acute lymphocytic leukemia were diagnosed as testicular relapse. According to the prevalence by the age groups, there were no patient under 2 years old, 14 out of 73(19.4%) in 2~9 years old and 1 out of 26(3.8%) over 10 years old groups. 2) At initial diagnosis of acute lymphocytic leukemia there were significant between testicular relapse and initial lymphadenopathy (p=0.09), but not with WBC count, hemoglobin leverl, platelet count, hepatomegaly and splenomegaly. 3) Mean duration to testicular relapse from initial diagnosis of acute lymphocytic leukemia was 3.1¡¾0.7 years. 4) Mean 15 patients, 7 cases combined with bone marrow or central nervous system relapse. Their survival rate was lower than isolated testicular relapse groups. 5) The 5 years survival rate of testicular relapsed patients was 67% after the combinations of chemotherapy, radiotherapy and orchiectomy.

Keywords :Testicular relapse, Acute lymphocytic leukemia, Childhood