All issues > Volume 36(6); 1993

Original Article

J Korean Pediatr Soc. 1993;36(6):820-829. Published online June 15, 1993.

Effect of Different Levels of the Dietary Protein on Long Term Prognosis of Experimental Renal Damage

Choon Haeng CH Lee¹, Sang Joo SJ Han¹, Hong Jin HJ Lee¹, Won Il WI Park¹, Kyung Ja KJ Lee¹, Young Eui YE Park², Min Chul MC Lee², Tae Heon TH Yoon³

¹Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea
²Department of Pathology, College of Medicine, Hallym University, Seoul, Korea
³Korean Institute of Nutrition, Hallym University, Chuncheon, Korea

Abstract

We examined the effect of various levels of dietary protein on long term prognosis of Adriamycinephropathy of S-D rat, fed with high protein(30%), intermediately low(10%), and strictly low(5%) protein diet for 15 weeks 1) In rats fed with strictly low protein diets(5%), proteinuria and serum creatinine decreased and creatinine clearance and histological changes were relatively well preserved. But hypoproteinmia and weight loss were more marked and 2 rats died due to severe ascites and pleural effusion in cachexic state 2) In rats fed with high protein diets(30%), general health condition and weight gain were relatively well preserved. But there were massive proteinuria, progressive increase in serum creatinine and progressive decrease in creatinine clearnce. Focal glomerular sclerosis and severe tublulointerstitial change on histologic examination were marked. 3) With intermediately low protein diet(10%), renal function and pasma protein levels were relatively well preserved compared with high protein diet group. But weight gain did not increase normally 4) We tentatively conclude that appropiately restricted dietary protein can prevent functional and histological renal damage. But too strict protien restriction aggravate nutitional state and general condition.

Keywords :Adriamycin-nephropathy, Protein restriction, Renal failure