All issues > Volume 36(6); 1993

Original Article

J Korean Pediatr Soc. 1993;36(6):830-836. Published online June 15, 1993.

Serum Alkaline Phosphatase Activity after Intravenous Administration of Albumin Preparation

June J Huh¹, Kang Mo KM Ahn¹, Ja Wook JW Koo¹, Il Soo IS Ha¹, Hae Il HI Cheong¹, Yong Y Choi¹

¹Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea

Abstract

Serum alkaline phosphatase(AP) activity is elevated in hepatobiliary disease, bone disease, pregnancy and certain neoplasms. Recently we experienced marked elevation of serum AP activity after administration of ablumin preparation in nephrotic patients who suffered from hypovolemic symptoms. So serum AP activity and the isoenzymes in the albumin preparations & patient뭩 serum after the administration of albumin preparation were studied. Serum AP activity was significantly predominant isoenzyme after administrationof albumin was significantly highter after administration of albumin preparation(318¡¾101IU/L) then before(123¡¾43IU/L). the was predominant before administration. AP activity in albumin preparation was high(2133¡¾14I0U/L) and the isoenzyme was mostly placental type. So we concluded that marked elevation of serum AP activity after administration of albumin was traced to the placental type AP isoenzyme in some albumin preparations which was manufactured from the plasma of placental origin. Elevated serum AP activity like these may lead to erroneous interpretation. Manufacturers should notify alkaline phosphatase activity in alboumin preparations of placental origin.

Keywords :Serum alkaline phosphatase, Albumin preparation